抗体

ITGA2抗体-C末端地区

MBS3216364

0.1毫升

335美元

多克隆

兔

未共轭

人类, 小鼠, 大鼠, 狗

免疫印迹, 免疫细胞化学

抗体

ITGA2抗体-C末端地区

[ITGA2]

[UBC;PDIA3;ATF2;ALB;ERGIC1;SHARPIN;ITGB1;PSMD4;AUP1;ITGA2;LAMA1;CD9;HSPG2;MMP1;COL8A1;COL1A2;COL1A1;ACTA1;RABIF;CD46]

[integrin alpha-2; Integrin alpha-2; integrin alpha-2; integrin subunit alpha 2; CD49 antigen-like family member B; Collagen receptor; Platelet membrane glycoprotein Ia; GPIa; VLA-2 subunit alpha]

[ITGA2]

[BR;CD49B;血小板表面胶原蛋白受体;VLA-2;VLAA2;BDPLT9]

[ITGA2;ITGA2;BR;血小板表面胶原蛋白受体;CD49B;HPA-5;VLA-2;VLAA2;CD49B;血小板表面胶原蛋白受体]

ITA2_HUMAN

多克隆

兔

Reacts with : Human. Predicted: Cow, Dog, Guinea Pig, Horse, Mouse, Pig, Rabbit, Rat

1181

LQNLQNQASLSFQALSESQEENKADNLVNLKIPLLYDAE
IHLTRSTNINF
Synthetic peptide located within the following region:

亲和纯化

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Lot dependent within range: 100 ul at 0.5-1 mg/ml "Please refer to the vial's label.

For short term use, store at 2-8 degree C up to 1 week. For long term storage, store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

免疫荧光(IF), 免疫印迹(免疫印迹)

免疫荧光(IF)

免疫印迹(免疫印迹)

Homology: Cow: 92%; Dog: 93%; Guinea Pig: 79%; Horse: 86%; Human: 100%; Mouse: 86%; Pig: 93%; Rabbit: 86%; Rat: 86%. Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human ITGA2

Polyclonal; Signaling Intermediate; Cell Adhesion; Membrane Protein;

This is a rabbit polyclonal antibody against ITGA2. It was validated on Western Blot. Target Description: This gene product belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane glycoproteins composed of a distinct alpha chain and a common beta chain. They are found on a wide variety of cell types including, T cells, fibroblasts and platelets. Integrins are involved in cell adhesion and also participate in cell-surface mediated signalling.

116295258

NP_002194

NM_002203

P17301

126kDa

Arf6 Trafficking Events Pathway (137954); Arrhythmogenic Right Ventricular Cardiomyopathy Pathway (672454); Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway (117293); Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway (116129); Axon Guidance Pathway (105688); CHL1 Interactions Pathway (161007); CXCR4-mediated Signaling Events Pathway (137910); Developmental Biology Pathway (477129); Dilated Cardiomyopathy Pathway (121494); Dilated Cardiomyopathy Pathway (121285)

This gene encodes the alpha subunit of a transmembrane receptor for collagens and related proteins. The encoded protein forms a heterodimer with a beta subunit and mediates the adhesion of platelets and other cell types to the extracellular matrix. Loss of the encoded protein is associated with bleeding disorder platelet-type 9. Antibodies against this protein are found in several immune disorders, including neonatal alloimmune thrombocytopenia. This gene is located adjacent to a related alpha subunit gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

ITGA2: Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix. Belongs to the integrin alpha chain family. Protein type: Motility/polarity/chemotaxis; Cell adhesion; Membrane protein, integral; Receptor, misc. Chromosomal Location of Human Ortholog: 5q11.2. Cellular Component: cell surface; focal adhesion; perinuclear region of cytoplasm; plasma membrane; nerve terminal; integrin complex; nucleus; external side of plasma membrane. Molecular Function: integrin binding; collagen binding; viral receptor activity; protein binding; protein heterodimerization activity; metal ion binding; laminin binding. Biological Process: axon guidance; entry of virus into host cell; extracellular matrix organization and biogenesis; response to muscle activity; positive regulation of positive chemotaxis; positive regulation of cell adhesion; positive regulation of translation; positive regulation of leukocyte migration; cell-matrix adhesion; positive regulation of smooth muscle cell proliferation; positive regulation of collagen binding; positive regulation of collagen biosynthetic process; positive regulation of cell projection organization and biogenesis; mesodermal cell differentiation; positive regulation of smooth muscle cell migration; response to L-ascorbic acid; response to organic cyclic substance; establishment of protein localization; mammary gland development; positive regulation of smooth muscle contraction; cell adhesion; positive regulation of DNA binding; substrate-bound cell migration; integrin-mediated signaling pathway; response to drug; skin morphogenesis; hypotonic response; cell-substrate adhesion; cellular response to hormone stimulus; cell proliferation; detection of mechanical stimulus involved in sensory perception of pain; organ morphogenesis; response to hypoxia; cell adhesion mediated by integrin; positive regulation of phagocytosis, engulfment; blood coagulation; positive regulation of transmission of nerve impulse; positive regulation of inflammatory response; response to amine stimulus. Disease: Bleeding Disorder, Platelet-type, 9

0.1毫升

335美元