抗体

小鼠抗人类CD2单克隆抗体, 异硫氰酸荧光素共轭标签克隆B-E2

MBS335155

100试验

310美元

单克隆

小鼠

异硫氰酸荧光素

[B-E2]

流式细胞仪, 流式细胞仪

抗体

小鼠抗人类CD2单克隆抗体, 异硫氰酸荧光素共轭标签克隆B-E2

[CD2]

[CD2;LFA-2]

[CD2 surface antigen; T-cell surface antigen CD2; T-cell surface antigen CD2; CD2 molecule; Erythrocyte receptor; LFA-2; LFA-3 receptor; Rosette receptor; T-cell surface antigen T11/Leu-5; CD_antigen: CD2]

[CD2]

[CD2;CD2;T11;SRBC;LFA-2;SRBC]

CD2_HUMAN

单克隆

Mouse IgG2b Kappa light chain

[B-E2]

小鼠

人类

360

Recognises the Lymphocyte Function associated Antigen-2 (LFA-2), a 50 kDa protein

离子交换层析

Phosphate-buffered saline with 5% BSA and 0.09% sodium azide

Stable at +2-8 degree C for 12 months. For longer storage freeze aliquots.

流式细胞仪(FC/流式细胞仪)

Working Dilution: Use 10 ul to label 10 6 cells or 100 mul of whole blood.

试验数据

Workshop: V

Antigen: CD2 / LFA-2. Hybridoma: Myeloma X63/AG.8653 x Balb/c spleen cells. Immunisation: Human thymocytes. Conjugation: FITC

Douglas et.al. J Immunol 2000

180094

AAA51946.1

P06729

39,448 Da

Cell Adhesion Molecules (CAMs) Pathway (83069); Cell Adhesion Molecules (CAMs) Pathway (480); Cell Surface Interactions At The Vascular Wall Pathway (1269373); Hematopoietic Cell Lineage Pathway (83078); Hematopoietic Cell Lineage Pathway (489); Hemostasis Pathway (1269340)

CD2 is a surface antigen of the human T-lymphocyte lineage that is expressed on all peripheral blood T cells (summarized by Sewell et al., 1986 [PubMed 3490670]). It is one of the earliest T-cell markers, being present on more than 95% of thymocytes; it is also found on some natural killer cells but not on B lymphocytes. Monoclonal antibodies directed against CD2 inhibit the formation of rosettes with sheep erythrocytes, indicating that CD2 is the erythrocyte receptor or is closely associated with it.[supplied by OMIM, Jul 2010]

CD2: CD2 interacts with lymphocyte function-associated antigen (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T- cells, the cytoplasmic domain is implicated in the signaling function. Protein type: Cell surface; Membrane protein, integral; Apoptosis. Chromosomal Location of Human Ortholog: 1p13.1. Cellular Component: internal side of plasma membrane; anchored to plasma membrane; cell surface; integral to plasma membrane; plasma membrane; extracellular region; intercellular junction; external side of plasma membrane. Molecular Function: protein binding; protein homodimerization activity; receptor activity; receptor binding. Biological Process: heterotypic cell-cell adhesion; cell-cell adhesion; cell surface receptor linked signal transduction; T cell activation; apoptosis; natural killer cell activation; regulation of T cell differentiation; blood coagulation; lipid raft polarization; positive regulation of tumor necrosis factor production; positive regulation of myeloid dendritic cell activation; leukocyte migration

100试验

310美元