产品简要
公司名称 :
MyBioSource
产品类型 :
抗体
产品名称 :
纤溶酶原激活物抑制因子1
目录 :
MBS340356
规格 :
1毫升
价格 :
350美元
克隆性 :
多克隆
宿主 :
共轭标签 :
nonconjugated
反应物种 :
人类
更多信息或购买 :
产品信息
目录号 :
MBS340356
产品类型 :
抗体
产品全称 :
纤溶酶原激活物抑制因子1
产品简称 :
纤溶酶原激活物抑制因子1
产品名称同义词 :
抗-纤溶酶原激活剂, INHIBITOR 1(PAI-1)
其他名称 :
plasminogen activator inhibitor 1 isoform 1; Plasminogen activator inhibitor 1; plasminogen activator inhibitor 1; serpin E1; OTTHUMP00000211478; endothelial plasminogen activator inhibitor; serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1; serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1; Endothelial plasminogen activator inhibitor; Serpin E1
产品基因名称 :
PAI-1
其他基因名称 :
SERPINE1;SERPINE1;PAI;PAI1;PAI-1;PLANH1;PAI1;PLANH1
UniProt数据库进入名 :
PAI1_HUMAN
克隆性 :
多克隆
宿主 :
序列长度 :
402
形式 :
Ig fraction
储存稳定性 :
Store at -20 degree C. Avoid repeated freeze/thaw cycles.
其它信息1 :
Immunogen: Recombinant Human PAI-1
其他信息2 :
Buffer: 20mM Phosphate, 150mM Sodium Chloride, pH 7.2. Preservative: 0.09% Sodium Azide
NCBI GI登录号 :
10835159
NCBI登录号 :
NP_000593.1
NCBI基因登录号 :
NM_000602.3
UniProt数据库登录号 :
P05121
NCBI分子量 :
45,060 Da
NCBI信号通路 :
Adipogenesis Pathway 198832!!Blood Clotting Cascade Pathway 198840!!Chagas Disease (American Trypanosomiasis) Pathway 147809!!Chagas Disease (American Trypanosomiasis) Pathway 147795!!Circadian Clock Pathway 187173!!Complement And Coagulation Cascades Pathway 198880!!Complement And Coagulation Cascades Pathway 83073!!Complement And Coagulation Cascades Pathway 484!!Direct P53 Effectors Pathway 137939!!Dissolution Of Fibrin Clot Pathway 106061
NCBI总结 :
This gene encodes a member of the serine proteinase inhibitor (serpin) superfamily. This member is the principal inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA), and hence is an inhibitor of fibrinolysis. Defects in this gene are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency), and high concentrations of the gene product are associated with thrombophilia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
UniProt数据库总结 :
Function: This inhibitor acts as 'bait' for tissue plasminogen activator, urokinase, and protein C. Its rapid interaction with TPA may function as a major control point in the regulation of fibrinolysis. Subunit structure: Interacts with VTN. Binds LRP1B; binding is followed by internalization and degradation. Ref.14 Ref.16. Subcellular location: Secreted. Tissue specificity: Found in plasma and platelets and in endothelial, hepatoma and fibrosarcoma cells. Post-translational modification: Inactivated by proteolytic attack of the urokinase-type (u-PA) and the tissue-type (TPA), cleaving the 369-Arg- -Met-370 bond. Involvement in disease: Defects in SERPINE1 are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1D) [. MIM:613329]. It is a hematologic disorder characterized by increased bleeding after trauma, injury, or surgery. Affected females have menorrhagia. The bleeding defect is due to increased fibrinolysis of fibrin blood clots due to deficiency of plasminogen activator inhibitor-1, which inhibits tissue and urinary activators of plasminogen. Ref.15Note=High concentrations of SERPINE1 seem to contribute to the development of venous but not arterial occlusions. Sequence similarities: Belongs to the serpin family.
规格 :
1毫升
价格 :
350美元
更多信息或购买 :
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
www.mybiosource.com
1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华,公司愿景是“生物研究试剂的源头”,现在位于圣地亚哥市。