产品简要
公司名称 :
MyBioSource
产品类型 :
蛋白
产品名称 :
Intercellular Adhesion Molecule-1 (Western Blot Control)
目录 :
MBS343048
规格 :
0.01毫克
价格 :
200美元
更多信息或购买 :
产品信息
目录号 :
MBS343048
产品类型 :
重组蛋白
产品全称 :
Intercellular Adhesion Molecule-1 (Western Blot Control)
产品简称 :
Intercellular Adhesion Molecule-1 (Western Blot Control)
产品名称同义词 :
ICAM-1; ICAM-1; Intercellular adhesion molecule, BB2, CD54, cell surface glycoprotein P3.58, human rhinovirus receptor, major group rhinovirus receptor
其他名称 :
intercellular adhesion molecule 1; Intercellular adhesion molecule 1; intercellular adhesion molecule 1; ICAM-1; human rhinovirus receptor; cell surface glycoprotein P3.58; major group rhinovirus receptor; intercellular adhesion molecule 1 (CD54), human rhinovirus receptor; intercellular adhesion molecule 1; Major group rhinovirus receptor
产品基因名称 :
ICAM-1
其他基因名称 :
细胞间粘附分子1;细胞间粘附分子1;BB2;CD54;P3.58
UniProt数据库进入名 :
ICAM1_HUMAN
纯度 :
Single band on Western blot
形式 :
Liquid. Supplied in 1x Laemmli Buffer (25mM Tris-HCl pH6.8, 50mM DTT, 1% (w/v) SDS, 0.1% (w/v) Bromophenol Blue, 2.5% Glycerol).
产品种类 :
人类重组蛋白
产品描述 :
ICAM-1 is a single chain membrane glycoprotein expressed on the surface of a variety of nonhaematopoietic and haematopoietic cell types and has roles in signal transduction, cell signalling and lymphocyte adhesion. Soluble ICAM-1 is detectable in the plasma and is elevated in patients with various inflammatory conditions. Our recombinant ICAM-1 comprises a 455 amino acid fragment (28-483) corresponding to the mature extracellular domain of the ICAM protein and is expressed in E. coli with an amino-terminal hexahistidine tag. This product is for research use only and is not intended for diagnostic or therapeutic use.
产品引用 :
Rothelin R et al. (1988) J. Immunol. 141(5) : 1665-1669.
NCBI GI登录号 :
33340673
NCBI登录号 :
AAQ14901.1
UniProt数据库登录号 :
P05362
NCBI分子量 :
57,825 Da
NCBI信号通路 :
Adaptive Immunity Signaling Pathway 366160!!African Trypanosomiasis Pathway 194384!!African Trypanosomiasis Pathway 194323!!Cell Adhesion Molecules (CAMs) Pathway 83069!!Cell Adhesion Molecules (CAMs) Pathway 480!!Cytokine Signaling In Immune System Pathway 366171!!Glucocorticoid Receptor Regulatory Network Pathway 138014!!HTLV-I Infection Pathway 373901!!HTLV-I Infection Pathway 373889!!IL-2 Signaling Pathway 198885
NCBI总结 :
This gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system. It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by Rhinovirus as a receptor. [provided by RefSeq]
UniProt数据库总结 :
Function: ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. In case of rhinovirus infection acts as a cellular receptor for the virus. Ref.12 Ref.13 Ref.14 Ref.18. Subunit structure: Homodimer. Probable. Interacts with human herpesvirus 8 MIR2 protein. Probable. Interacts with MUC1 and promotes cell aggregation in epithelial cells. Interacts with ARHGEF26/SGEF. Binds to coxsackievirus A21 capsid proteins and acts as a receptor for this virus. Ref.14 Ref.15 Ref.18 Ref.27 Ref.28. Subcellular location: Membrane; Single-pass type I membrane protein. Post-translational modification: Monoubiquitinated, which is promoted by MARCH9 and leads to endocytosis. Polymorphism: Homozygotes with ICAM1-Kalifi Met-56 seem to have an increased risk for cerebral malaria. Sequence similarities: Belongs to the immunoglobulin superfamily. ICAM family.Contains 5 Ig-like C2-type (immunoglobulin-like) domains.
规格 :
0.01毫克
价格 :
200美元
更多信息或购买 :
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
www.mybiosource.com
1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华,公司愿景是“生物研究试剂的源头”,现在位于圣地亚哥市。