产品简要
公司名称 :
MyBioSource
产品类型 :
蛋白
产品名称 :
Tissue Factor (33-251)
目录 :
MBS343186
规格 :
0.01毫克
价格 :
235美元
更多信息或购买 :
产品信息
目录号 :
MBS343186
产品类型 :
重组蛋白
产品全称 :
Tissue Factor (33-251)
产品简称 :
Tissue Factor (33-251)
产品名称同义词 :
Tissue Factor (33-251); Tissue Factor; Coagulation Factor III; TF; Tissue Thromboplastin; CD142
其他名称 :
tissue factor; Tissue factor; tissue factor; OTTHUMP00000012426; OTTHUMP00000012427; coagulation factor III (thromboplastin, tissue factor); Coagulation factor III; Thromboplastin
其他基因名称 :
F3;F3;TF;TFA;CD142;FLJ17960
UniProt数据库进入名 :
TF_HUMAN
纯度 :
>95% by SDS-PAGE
形式 :
Liquid
产品种类 :
人类重组蛋白
产品描述 :
Tissue factor is best known as the primary cellular initiator of blood coagulation. After vessel injury, the Tissue Factor : Factor VIIa complex activates the coagulation protease cascade, which leads to fibrin deposition and activation of platelets. In addition, aberrant Tissue Factor expression within the vasculature initiates lifethreatening thrombosis in various diseases, such as sepsis, atherosclerosis, and cancer. Our recombinant Tissue Factor comprises a 219 amino acid fragment (33-251) corresponding to the extracellular domain of Tissue Factor protein and is expressed in E. coli with an aminoterminal hexahistidine tag. This product is for research use only and is not intended for diagnostic or therapeutic use.
产品引用 :
Carlsson, K. et al. (2003) European Journal of Biochemistry 270 (12): 2576-82. Zhang, E. et al. (1999). Journal of Molecular Biology 285 (5): 2089- 104.
NCBI GI登录号 :
339506
UniProt数据库登录号 :
P13726
NCBI分子量 :
33,068 Da
NCBI信号通路 :
Complement And Coagulation Cascades Pathway 198880!!Complement And Coagulation Cascades Pathway 83073!!Complement And Coagulation Cascades Pathway 484!!Extrinsic Pathway 106058!!Formation Of Fibrin Clot (Clotting Cascade) Pathway 106057!!Hemostasis Pathway 106028
NCBI总结 :
This gene encodes coagulation factor III which is a cell surface glycoprotein. This factor enables cells to initiate the blood coagulation cascades, and it functions as the high-affinity receptor for the coagulation factor VII. The resulting complex provides a catalytic event that is responsible for initiation of the coagulation protease cascades by specific limited proteolysis. Unlike the other cofactors of these protease cascades, which circulate as nonfunctional precursors, this factor is a potent initiator that is fully functional when expressed on cell surfaces. There are 3 distinct domains of this factor: extracellular, transmembrane, and cytoplasmic. This protein is the only one in the coagulation pathway for which a congenital deficiency has not been described. Alternate splicing results in multiple transcript variants.
UniProt数据库总结 :
Function: Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited protolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade. Subunit structure: Interacts with HSPE; the interaction, inhibited by heparin, promotes the generation of activated factor X and activates coagulation in the presence of activated factor VII. Ref.13. Subcellular location: Membrane; Single-pass type I membrane protein. Induction: TF expression is highly dependent upon cell type. TF can also be induced by the inflammatory mediators interleukin 1 and TNF, as well as by endotoxin, to appear on monocytes and vascular endothelial cells as a component of cellular immune response. Sequence similarities: Belongs to the tissue factor family.
规格 :
0.01毫克
价格 :
235美元
更多信息或购买 :
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
www.mybiosource.com
1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华,公司愿景是“生物研究试剂的源头”,现在位于圣地亚哥市。