产品简要
公司名称 :
MyBioSource
产品类型 :
抗体
产品名称 :
细胞角蛋白35BH11
目录 :
MBS370053
规格 :
3毫升
价格 :
225美元
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
35betaH11
反应物种 :
人类
更多信息或购买 :
产品信息
目录号 :
MBS370053
产品类型 :
抗体
产品全称 :
细胞角蛋白35BH11
产品简称 :
细胞角蛋白35BH11
其他名称 :
cytokeratin 8; Keratin, type II cytoskeletal 8; keratin, type II cytoskeletal 8; CK-8; keratin-8; cytokeratin 8; cytokeratin-8; type-II keratin Kb8; keratin 8; Cytokeratin-8; CK-8; Keratin-8; K8; Type-II keratin Kb8
其他基因名称 :
KRT8;KRT8;K8;KO;CK8;CYK8;K2C8;CARD2;CYK8
UniProt数据库进入名 :
K2C8_HUMAN
克隆性 :
单克隆
抗体亚型 :
IgM
克隆 :
35betaH11
宿主 :
小鼠
形式 :
Cytokeratin 8/35betaH11 is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
储存稳定性 :
Store at 2 to 8 degree C in the dark.
其它信息1 :
Control: Prostate, Colon. Localization: Cytoplasmic
其他信息2 :
Reactivity Note: Paraffin, Frozen
产品描述 :
Cytokeratin 8 belongs to the Type II (basic) subfamily of high molecular-weight keratins and exists in combination with cytokeratin 18. Cytokeratin 8 is primarily found in the non-squamous epithelia and is present in the majority of Adenocarcinomas and Ductal Carcinomas. It is absent in Squamous Cell Carcinomas. Hepatocellular Carcinomas are defined by the use of antibodies that recognize only cytokeratin polypeptides 8 and 18. Anti-Cytokeratin 8/35betaH11 stains most Non-Squamous Epithelial tumors; Squamous tumors are negative for this antibody as a rule. This antibody stains Adenocarcinomas of the breast, ovary, gastrointestinal tract, thyroid, pancreas, bile duct, and salivary glands. This antibody does not react with skeletal muscle or nerve cells.
NCBI GI登录号 :
181573
UniProt数据库登录号 :
P05787
NCBI分子量 :
53,704 Da
NCBI信号通路 :
EGFR1 Signaling Pathway 198782!!Signaling Mediated By P38-alpha And P38-beta Pathway 138012
NCBI总结 :
This gene is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. The product of this gene typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells. This protein plays a role in maintaining cellular structural integrity and also functions in signal transduction and cellular differentiation. Mutations in this gene cause cryptogenic cirrhosis. [provided by RefSeq]
UniProt数据库总结 :
Function: Together with KRT19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle. Ref.19. Subunit structure: Heterotetramer of two type I and two type II keratins. Keratin-8 associates with keratin-18. Associates with KRT20. Interacts with HCV core protein and PNN. When associated with KRT19, interacts with DMD. Interacts with TCHP. Interacts with APEX1. Ref.13 Ref.14 Ref.17 Ref.19 Ref.20 Ref.22 Ref.30. Subcellular location: Cytoplasm. Nucleus nucleoplasm. By similarity. Nucleus matrix. By similarity Ref.13 Ref.30. Tissue specificity: Observed in muscle fibers accumulating in the costameres of myoplasm at the sarcolemma membrane in structures that contain dystrophin and spectrin. Expressed in gingival mucosa and hard palate of the oral cavity. Ref.13 Ref.19. Post-translational modification: Phosphorylation on serine residues is enhanced during EGF stimulation and mitosis. Ser-74 phosphorylation plays an important role in keratin filament reorganization.O-glycosylated at multiple sites; glycans consist of single N-acetylglucosamine residues. Ref.12. Involvement in disease: Defects in KRT8 are a cause of cirrhosis (CIRRH) [. MIM:215600]. Ref.34. Miscellaneous: There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa). Sequence similarities: Belongs to the intermediate filament family.
规格 :
3毫升
价格 :
225美元
更多信息或购买 :
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华,公司愿景是“生物研究试剂的源头”,现在位于圣地亚哥市。