产品简要
公司名称 :
MyBioSource
产品类型 :
抗体
产品名称 :
FITC-conjugated Goat Anti-Human ApolipoproteinB-100
目录 :
MBS390004
规格 :
0.5毫升
价格 :
265美元
克隆性 :
多克隆
宿主 :
山羊
共轭标签 :
异硫氰酸荧光素
反应物种 :
人类
应用 :
免疫细胞化学
更多信息或购买 :
产品信息
目录号 :
MBS390004
产品类型 :
抗体
产品全称 :
FITC-conjugated Goat Anti-Human ApolipoproteinB-100
产品简称 :
ApolipoproteinB-100
产品名称同义词 :
异硫氰酸荧光素共轭标签山羊抗人类载脂蛋白b-100(载脂蛋白B-100), 多克隆抗体
其他名称 :
载脂蛋白b-100;载脂蛋白b-100;载脂蛋白b-100;载脂蛋白B 48;载脂蛋白B 100;载脂蛋白B-100;突变体载脂蛋白B 100;载脂蛋白B48;载脂蛋白b(包括老化(x)抗原);载脂蛋白b
其他基因名称 :
载脂蛋白B;载脂蛋白B;FLDB;LDLCQ4;载脂蛋白B-100;载脂蛋白B-48
UniProt数据库进入名 :
APOB_HUMAN
宿主 :
山羊
序列长度 :
4563
特异性 :
Specifically binds to human apo B-100. Molar F/P ratio is 6.1. The investigator should determine working dilutions.
浓度 :
1毫克/毫升
储存稳定性 :
Freeze-dried product should be refrigerated until opened. After opening, restore to 1.0 ml with distilled water. If it is not completely clear after standing for 1-2 hours at room temperature, centrifuge the product. It is stable for several weeks at 4 degree C as an undiluted liquid. Do not use for more than one day after dilution. The products are light sensitive and should be kept in dark. To avoid repeated freezing and thawing after reconstitution, we suggest aliquots and storage at -20 degree C. Expiration: One year from date of reconstitution.
检测过的应用 :
免疫荧光(IF)
应用笔记 :
Molar F/P Ratio: 6.1. Freeze-dried powder. Use: The antibody can be used for detection of apo B-100/48 with immuno-fluoroscent approach.
其它信息1 :
Source Note: Polyclonal antibody purified by human apo B-100-Sepharose affinity column and labeled with FITC.
其他信息2 :
Preservative: 75 mM Sodium Phosphate, 75 mM NaCl, 0.5 mM EDTA, 0.02% NaN3, pH 7.4. Stabilizer: 5 mg / ml Bovine Serum Albumin. Size and Physical State: 1.0 ml in Freeze-dried powder.
产品种类 :
异硫氰酸荧光素抗体
NCBI GI登录号 :
105990532
NCBI登录号 :
NP_000375.2
NCBI基因登录号 :
NM_000384.2
UniProt数据库登录号 :
P04114
NCBI分子量 :
515,605 Da
NCBI信号通路 :
Binding And Uptake Of Ligands By Scavenger Receptors Pathway (771599); Cell Surface Interactions At The Vascular Wall Pathway (106062); Chylomicron-mediated Lipid Transport Pathway (106157); Disease Pathway (530764); Diseases Associated With Visual Transduction Pathway (771581); FOXA1 Transcription Factor Network Pathway (137979); Fat Digestion And Absorption Pathway (194385); Fat Digestion And Absorption Pathway (194324); Hemostasis Pathway (106028); LDL-mediated Lipid Transport Pathway (106159)
NCBI总结 :
This gene product is the main apolipoprotein of chylomicrons and low density lipoproteins. It occurs in plasma as two main isoforms, apoB-48 and apoB-100: the former is synthesized exclusively in the gut and the latter in the liver. The intestinal and the hepatic forms of apoB are encoded by a single gene from a single, very long mRNA. The two isoforms share a common N-terminal sequence. The shorter apoB-48 protein is produced after RNA editing of the apoB-100 transcript at residue 2180 (CAA- UAA), resulting in the creation of a stop codon, and early translation termination. Mutations in this gene or its regulatory region cause hypobetalipoproteinemia, normotriglyceridemic hypobetalipoproteinemia, and hypercholesterolemia due to ligand-defective apoB, diseases affecting plasma cholesterol and apoB levels. [provided by RefSeq, Jul 2008]
UniProt数据库总结 :
Function: Apolipoprotein B is a major protein constituent of chylomicrons (apo B-48), LDL (apo B-100) and VLDL (apo B-100). Apo B-100 functions as a recognition signal for the cellular binding and internalization of LDL particles by the apoB/E receptor. Subunit structure: Interacts with PCSK9. Ref.38. Subcellular location: Cytoplasm. Secreted Ref.38. Induction: Up-regulated in response to enterovirus 71 (EV71) infection (at protein level). Ref.34. Post-translational modification: Palmitoylated; structural requirement for proper assembly of the hydrophobic core of the lipoprotein particle. Ref.31. Involvement in disease: Familial hypobetalipoproteinemia 1 (FHBL1) [MIM:107730]: A disorder of lipid metabolism characterized by less than 5th percentile age- and sex-specific levels of low density lipoproteins, and dietary fat malabsorption. Clinical presentation may vary from no symptoms to severe gastrointestinal and neurological dysfunction similar to abetalipoproteinemia.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.46Familial ligand-defective apolipoprotein B-100 (FDB) [MIM:144010]: Dominantly inherited disorder of lipoprotein metabolism leading to hypercholesterolemia and increased proneness to coronary artery disease (CAD). The plasma cholesterol levels are dramatically elevated due to impaired clearance of LDL particles by defective APOB/E receptors.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.40 Ref.42 Ref.44 Ref.49Defects in APOB associated with defects in other genes (polygenic) can contribute to hypocholesterolemia. Sequence similarities: Contains 1 vitellogenin domain. RNA editing: Edited at position 2180.The stop codon (UAA) at position 2180 is created by RNA editing. Apo B-48, derived from the fully edited RNA, is produced only in the intestine and is found in chylomicrons. Apo B-48 is a shortened form of apo B-100 which lacks the LDL-receptor region. The unedited version (apo B-100) is produced by the liver and is found in the VLDL and LDL. Sequence caution: The sequence AAA51752.1 differs from that shown. Reason: Frameshift at positions 942, 951, 1139, 1165, 1164, 1371 and 1385.
尺寸1 :
0.5毫升
价格1 :
265美元
尺寸2 :
1毫升
价格2 :
390
更多信息或购买 :
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华,公司愿景是“生物研究试剂的源头”,现在位于圣地亚哥市。