产品简要
公司名称 :
MyBioSource
产品类型 :
抗体
产品名称 :
基质金属蛋白酶3(MMP3)
目录 :
MBS395183
规格 :
0.2毫克
价格 :
325美元
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
[1B4]
反应物种 :
人类
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化, 酶免疫法
更多信息或购买 :
图像
图像 1 :
MyBioSource MBS395183 图像 1
Left: Immunohistochemical staining of human gastric carcinoma tissue using MMP-3 antibody .
产品信息
目录号 :
MBS395183
产品类型 :
抗体
产品全称 :
基质金属蛋白酶3(MMP3)
产品简称 :
[基质金属蛋白酶3(MMP3)]
产品名称同义词 :
[SL-1; Matrix metalloproteinase-3; MMP-3; Transin-1]
其他名称 :
[stromelysin-1 preproprotein; Stromelysin-1; stromelysin-1; transin-1; proteoglycanase; matrix metalloproteinase-3; matrix metalloproteinase 3 (stromelysin 1, progelatinase); matrix metallopeptidase 3 (stromelysin 1, progelatinase); Matrix metalloproteinase-3; MMP-3; Transin-1]
产品基因名称 :
[MMP3]
其他基因名称 :
[MMP3;MMP3;SL-1;STMY;STR1;CHDS6;基质金属蛋白酶-3;STMY1;STMY1;SL-1;基质金属蛋白酶-3]
UniProt数据库进入名 :
MMP3_HUMAN
克隆性 :
单克隆
抗体亚型 :
IgG1
克隆 :
[1B4]
宿主 :
小鼠
反应物种 :
人类
序列长度 :
477
纯度 :
蛋白质A/G色谱
形式 :
Unconjugated; Provided as solution in phosphate buffered saline with 0.08% sodium azide
储存稳定性 :
Product should be stored at -20 degree C. Aliquot to avoid freeze/thaw cycles. Ship at ambient temperature, freeze upon arrival.
检测过的应用 :
酶联免疫吸附测定(EIA), 免疫印迹(免疫印迹), 免疫组化(免疫组化)
应用笔记 :
Antibody can be used for Western blotting (1-2 ug/ml) and immunohistochemistry on formlin-fixed paraffin-embedded tissue sections (1-5 ug/ml). Optimal concentration should be evaluated by serial dilutions. Functional Analysis: Western Blotting
image1头 :
免疫组化(免疫组化)
其它信息1 :
Immunogen: Hybridoma produced by the fusion of splenocytes from BALB/c mice immunized with a synthetic peptide derived from the C-terminus of the human MMP3 protein and mouse myeloma Ag8563 cells.
其他信息2 :
Positive Control: Oesophageal and gastric tissues. Expressed at higher levels in tumor.
产品种类 :
单克隆抗体;细胞外间质
产品描述 :
The matrix metalloproteinases (MMP) are a family of peptidase enzymes responsible for the degradation of extracellular matrix components, including Collagen, gelatin, Fibronectin, Laminin and proteoglycan. Transcription of MMP genes is differentially activated by phorbol ester, lipopolysaccharide (LPS) or staphylococcal enterotoxin B (SEB). MMP catalysis requires both calcium and zinc. MMP-3, MMP-10 and MMP-11 (also designated stromelysin-1, 2 and 3, respectively) activate procollagenase. MMP-3 activation of procollagenase can occur via two pathways. Direct activation by MMP-3 is slow and activation by MMP-3 in conjunction with tissue or plasma proteinases is rapid. MMP-10 is expressed in small intestine, and at lower levels in lung and heart. MMP-11 is specifically expressed in stromal cells of breast carcinomas and contributes to epithelial cell malignancies.
NCBI GI登录号 :
4505217
NCBI登录号 :
NP_002413.1
NCBI基因登录号 :
NM_002422.3
UniProt数据库登录号 :
P08254
NCBI信号通路 :
Activation Of Matrix Metalloproteinases Pathway (576264); Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway (730306); Collagen Formation Pathway (645288); Degradation Of Collagen Pathway (730309); Degradation Of Collagen Pathway (827690); Degradation Of The Extracellular Matrix Pathway (576263); Degradation Of The Extracellular Matrix Pathway (827688); EGFR Transactivation By Gastrin Pathway (645296); Extracellular Matrix Organization Pathway (576262); Extracellular Matrix Organization Pathway (827676)
NCBI总结 :
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades fibronectin, laminin, collagens III, IV, IX, and X, and cartilage proteoglycans. The enzyme is thought to be involved in wound repair, progression of atherosclerosis, and tumor initiation. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq, Jul 2008]
UniProt数据库总结 :
Function: Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase. Catalytic activity: Preferential cleavage where P1', P2' and P3' are hydrophobic residues. Cofactor: Binds 4 calcium ions per subunit.Binds 2 zinc ions per subunit. Subcellular location: Secreted extracellular space extracellular matrix . Probable. Domain: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme. Ref.13. Involvement in disease: Coronary heart disease 6 (CHDS6) [MIM:614466]: A multifactorial disease characterized by an imbalance between myocardial functional requirements and the capacity of the coronary vessels to supply sufficient blood flow. Decreased capacity of the coronary vessels is often associated with thickening and loss of elasticity of the coronary arteries.Note: Disease susceptibility is associated with variations affecting the gene represented in this entry. A polymorphism in the MMP3 promoter region is associated with the risk of coronary heart disease and myocardial infarction, due to lower MMP3 proteolytic activity and higher extracellular matrix deposition in atherosclerotic lesions. Ref.11 Ref.12. Sequence similarities: Belongs to the peptidase M10A family.Contains 4 hemopexin repeats.
尺寸1 :
0.2毫克
价格1 :
325美元
更多信息或购买 :
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华,公司愿景是“生物研究试剂的源头”,现在位于圣地亚哥市。