抗体

白细胞介素1 RA(hIL-1RA)生物素

MBS395589

0.2毫克

315美元

多克隆

兔

生物素

酶联免疫吸附测定, 酶免疫法

抗体

白细胞介素1 RA(hIL-1RA)生物素

白细胞介素1 RA(hIL-1RA)

IL1RA;兔抗人类白细胞介素1 RA;生物素共轭标签

interleukin-1 receptor antagonist protein isoform 3; Interleukin-1 receptor antagonist protein; interleukin-1 receptor antagonist protein; IL1 inhibitor; IL1RN (IL1F3); type II interleukin-1 receptor antagonist; intracellular IL-1 receptor antagonist type II; intracellular interleukin-1 receptor antagonist (icIL-1ra); interleukin 1 receptor antagonist; ICIL-1RA; IL1 inhibitor

IL-1RA

IL1RN;IL1RN;DIRA;IRAP;IL1F3;IL1RA;MVCD4;IL-1RN;IL-1ra;IL-1ra3;ICIL-1RA;IL1F3;IL1RA;IL-1RN;IL-1ra;IRAP

IL1RA_HUMAN

多克隆

IgG

兔

人类

159

蛋白质A/G色谱

Provided as solution in phosphate buffered saline with 0.08% sodium azide

1毫克/毫升

Product should be stored at -20 degree C. Aliquot to avoid freeze/thaw cycles. Stability: Antibodies are stable for one year from purchase if stored frozen.

酶联免疫吸附测定(EIA)

ELISA:This antibody has been used as a solution-phase antibody at 2ug/ml in a two-site ELISA with unconjugated IL-1ra antibody. Typically the ELISA has a working range of 27-2000pg/ml and a sensitivity of 85% in the ELISA. Can also be used for immunoprecipitation in solution using a double-antibody method and Western Blot at 10ug/ml.

Immunogen: Human recombinant interleukin 1 receptor antagonist (hIL-1RA). Acession Number: P18510,Human

Positive Control: Specificity: Recognizes human IL-1RA. Does not recognize hIL-1alpha, hIL-1beta or a panel of other human cytokines.

多克隆抗体;细胞因子

Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells. The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins.

10835147

NP_000568.1

NM_000577.4

P18510

30.748

Cytokine Signaling In Immune System Pathway (366171); IL-1 Signaling Pathway (198908); IL1-mediated Signaling Events Pathway (137944); Immune System Pathway (106386); Interleukin-1 Signaling Pathway (160141); Leptin Signaling Pathway (672456); SIDS Susceptibility Pathways (198901); Signaling By Interleukins Pathway (160140)

The protein encoded by this gene is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1, alpha (IL1A) and interleukin 1, beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses. This gene and five other closely related cytokine genes form a gene cluster spanning approximately 400 kb on chromosome 2. A polymorphism of this gene is reported to be associated with increased risk of osteoporotic fractures and gastric cancer. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

Function: Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling. Has no interleukin-1 like activity. Binds functional interleukin-1 receptor IL1R1 with greater affinity than decoy receptor IL1R2; however, the physiological relevance of the latter association is unsure. Ref.17. Subcellular location: Isoform 1: Secreted. Isoform 2: Cytoplasm. Isoform 3: Cytoplasm. Isoform 4: Cytoplasm. Tissue specificity: The intracellular form of IL1RN is predominantly expressed in epithelial cells. Involvement in disease: Microvascular complications of diabetes 4 (MVCD4) [MIM:612628]: Pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis.Note: Disease susceptibility is associated with variations affecting the gene represented in this entry.Interleukin 1 receptor antagonist deficiency (DIRA) [MIM:612852]: A rare autoinflammatory disease of skin and bone resulting in sterile multifocal osteomyelitis, periostitis, and pustulosis from birth. The term autoinflammatory disease describes a group of disorders characterized by attacks of seemingly unprovoked inflammation without significant levels of autoantibodies and autoreactive T-cells.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.21. Pharmaceutical use: Available under the name Kineret (Amgen). Used for the reduction in signs and symptoms and slowing the progression of structural damage in moderately to severely active rheumatoid arthritis.

0.2毫克

315美元