抗体

抗趋化因子受体4抗体

MBS416768

0.1毫升

230美元

多克隆

兔

未共轭

人类, 小鼠, 大鼠

免疫印迹, 酶联免疫吸附测定, 免疫组化, 酶免疫法

抗体

抗趋化因子受体4抗体

[趋化因子受体4]

[CXCR4; C-X-C chemokine receptor type 4; C-X-C chemokine receptor type 4; CD184 antigen; LPS-associated protein 3; SDF-1 receptor; fusin; leukocyte-derived seven transmembrane domain receptor; lipopolysaccharide-associated protein 3; neuropeptide Y receptor Y3; seven transmembrane helix receptor; seven-transmembrane-segment receptor, spleen; stromal cell-derived factor 1 receptor; chemokine (C-X-C motif) receptor 4; FB22; Fusin; HM89; LCR1; Leukocyte-derived seven transmembrane domain receptor; LESTR; Lipopolysaccharide-associated protein 3; LAP-3; LPS-associated protein 3; NPYRL; Stromal cell-derived factor 1 receptor; SDF-1 receptor; CD_antigen: CD184]

[趋化因子受体4]

[趋化因子受体4;趋化因子受体4;FB22;HM89;LAP3;LCR1;NPYR;WHIM;CD184;LAP-3;LESTR;NPY3R;NPYRL;WHIMS;HSY3RR;NPYY3R;D2S201E]

CXCR4_HUMAN

多克隆

IgG

兔

人类, 小鼠, 大鼠

360

亲和纯化

液体

100微克/100微升

This product is stable for several weeks at 4 degree C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20 degree C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.

酶联免疫吸附测定(EIA), 免疫印迹(免疫印迹), 免疫组化(免疫组化)

Peptide ELISA titer: 1:40,000-1:80,000. Western blot analysis: 1:200-500. Optimal dilutions/concentrations should be determined by the end user.

免疫印迹(免疫印迹)

免疫组化(免疫组化)#2(免疫组化)

Antibody Type: Primary Antibody. Storage Buffer: PBS, pH 7.4 with 0.02% Sodium Azide

Immunogen: Rabbit polyclonal CXCR4 (1) antibody was raised against a 16 amino acid peptide from near the N terminal residues of human CXCR4 protein.

(1) Loetscher,M., Geiser,T., O'Reilly,T.et,al Cloning of a human seven-transmembrane domain receptor, LESTR, that is highly expressed in leukocytes.J. Biol. Chem. 1994;269 (1):232-237.

3059120

CAA12166.1

P61073

40,221 Da

Axon Guidance Pathway (83065); Axon Guidance Pathway (476); Binding And Entry Of HIV Virion Pathway (105986); CXCR4-mediated Signaling Events Pathway (137910); Cardiac Progenitor Differentiation Pathway (712094); Chemokine Receptors Bind Chemokines Pathway (106359); Chemokine Signaling Pathway (99051); Chemokine Signaling Pathway (96864); Class A/1 (Rhodopsin-like Receptors) Pathway (106357); Cytokine-cytokine Receptor Interaction Pathway (83051)

This gene encodes a CXC chemokine receptor specific for stromal cell-derived factor-1. The protein has 7 transmembrane regions and is located on the cell surface. It acts with the CD4 protein to support HIV entry into cells and is also highly expressed in breast cancer cells. Mutations in this gene have been associated with WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

CXCR4: Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 X4 isolates and as a primary receptor for some HIV-2 isolates. Promotes Env-mediated fusion of the virus. Monomer. Can form dimers. Interacts with CD164. Interacts with HIV-1 surface protein gp120 and Tat. Interacts with ARRB2; the interaction is dependent on the C-terminal phosphorylation of CXCR4 and allows activation of MAPK1 and MAPK3. Interacts with ARRC; the interaction is dependent on the C-terminal phosphorylation of CXCR4 and modulates calcium mobilization. Interacts (via the cytoplasmic C-terminal) with ITCH (via the WW domains I and II); the interaction, enhanced by CXCL12, ubiquitinates CXCR4 and leads to its degradation. Interacts with extracellular ubiquitin. Interacts with human cytomegalovirus/HHV- 5 protein UL78. Expressed in numerous tissues, such as peripheral blood leukocytes, spleen, thymus, spinal cord, heart, placenta, lung, liver, skeletal muscle, kidney, pancreas, cerebellum, cerebral cortex and medulla (in microglia as well as in astrocytes), brain microvascular, coronary artery and umbilical cord endothelial cells. Isoform 1 is predominant in all tissues tested. Belongs to the G-protein coupled receptor 1 family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: GPCR, family 1; Receptor, GPCR; Membrane protein, integral; Membrane protein, multi-pass. Chromosomal Location of Human Ortholog: 2q21. Cellular Component: growth cone; cell surface; lysosome; late endosome; early endosome; leading edge; cytoplasm; cytoplasmic membrane-bound vesicle; integral to membrane; plasma membrane; cytoplasmic vesicle; intercellular junction; external side of plasma membrane. Molecular Function: viral receptor activity; G-protein coupled receptor activity; ubiquitin binding; protein binding; ubiquitin protein ligase binding; cytokine binding; coreceptor activity; myosin light chain binding; actin binding; C-X-C chemokine receptor activity. Biological Process: entry of virus into host cell; regulation of chemotaxis; viral reproduction; neutrophil activation; apoptosis; activation of MAPK activity; response to virus; neuron migration; calcium-mediated signaling; motor axon guidance; regulation of cell migration; germ cell development; patterning of blood vessels; T cell proliferation; G-protein coupled receptor protein signaling pathway; elevation of cytosolic calcium ion concentration; ameboidal cell migration; myelin maintenance; germ cell migration; response to hypoxia; dendritic cell chemotaxis; entry into host cell; positive regulation of oligodendrocyte differentiation; brain development; inflammatory response. Disease: Whim Syndrome

0.1毫升

230美元