抗体

Anti-TrkB Antibody

MBS417499

0.1毫克

325美元

多克隆

兔

未共轭

人类, 小鼠, 大鼠

抗体

Anti-TrkB Antibody

[TrkB]

[Anti-TrkB (Phospho-Tyr515) Antibody]

[trkB; BDNF/NT-3 growth factors receptor; BDNF/NT-3 growth factors receptor; BDNF-tropomyosine receptor kinase B; tropomyosin-related kinase B; tyrosine kinase receptor B; neurotrophic tyrosine kinase, receptor, type 2; GP145-TrkB; Trk-B; Neurotrophic tyrosine kinase receptor type 2; TrkB tyrosine kinase; Tropomyosin-related kinase B]

[TrkB]

[NTRK2; NTRK2; TRKB; trk-B; GP145-TrkB]

NTRK2_HUMAN

多克隆

IgG

兔

人类, 小鼠, 大鼠

822

TrkB (Phospho-Tyr515) Antibody detects endogenous levels of TrkB only when phosphorylated at tyrosine 515.

亲和纯化

液体

100微克/100微升

This product is stable for several weeks at 4 degree C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20 degree C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.

免疫荧光(IF)

IF:1:100~1:200

试验数据

Antibody type: Primary antibody. Storage Buffer: Rabbit IgG in phosphate buffered saline (without Mg 2 + and Ca 2 +), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Immunogen: The antibody was produced against synthesized phosphopeptide derived from human TrkB around the phosphorylation site of tyrosine 515 (P-Q-Y-PF-G).

913718

AAB33109.1

35,332 Da

Activation Of TRKA Receptors Pathway (106456); Alcoholism Pathway (585563); Alcoholism Pathway (587116); BDNF Signaling Pathway (712093); MAPK Signaling Pathway (83048); MAPK Signaling Pathway (456); NGF Signalling Via TRKA From The Plasma Membrane Pathway (106459); NGF-independant TRKA Activation Pathway (106458); Neurotrophic Factor-mediated Trk Receptor Signaling Pathway (137977); Neurotrophin Signaling Pathway (101143)

This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation. Mutations in this gene have been associated with obesity and mood disorders. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

TrkB: a receptor tyrosine kinase of the Trk family. Receptor for brain-derived neurotrophic factor (BDNF), neurotrophin-3, -4 and -5 but not nerve growth factor (NGF). Involved in the development and maintenance of the nervous system. Three splice variant isoforms have been described. Protein type: Protein kinase, tyrosine (receptor); EC 2.7.10.1; Membrane protein, integral; Protein kinase, TK; Kinase, protein; TK group; Trk family. Chromosomal Location of Human Ortholog: 9q22.1. Cellular Component: cell surface; rough endoplasmic reticulum; integral to plasma membrane; dendritic spine; terminal button; excitatory synapse; perikaryon; cytosol; postsynaptic membrane; growth cone; presynaptic active zone; endosome membrane; receptor complex. Molecular Function: brain-derived neurotrophic factor receptor activity; neurotrophin binding; protein homodimerization activity; ephrin receptor binding; brain-derived neurotrophic factor binding; ATP binding. Biological Process: circadian rhythm; mechanoreceptor differentiation; peptidyl-tyrosine phosphorylation; retinal rod cell development; nerve growth factor receptor signaling pathway; protein amino acid autophosphorylation; neuron migration; regulation of dendrite development; regulation of neurotransmitter secretion; positive regulation of synaptic transmission, glutamatergic; neuron differentiation; positive regulation of MAPKKK cascade; positive regulation of cell proliferation; oligodendrocyte differentiation; feeding behavior; negative regulation of neuron apoptosis; inflammatory response; vasculogenesis; neuromuscular junction development; central nervous system neuron development; aging; response to light stimulus; brain-derived neurotrophic factor receptor signaling pathway; adenylate cyclase activation; regulation of protein kinase B signaling cascade; learning; positive regulation of peptidyl-serine phosphorylation; positive regulation of phosphoinositide 3-kinase cascade; peripheral nervous system neuron development; long-term memory; glutamate secretion; positive regulation of axonogenesis; cerebral cortex development; transmembrane receptor protein tyrosine kinase signaling pathway. Disease: Obesity, Hyperphagia, And Developmental Delay

0.1毫克

325美元