抗体

Goat anti-FOXP3/Scurfin (Mouse) Antibody

MBS420161

0.1毫克

300美元

多克隆

山羊

未共轭

小鼠, 大鼠

免疫组化, 酶免疫法

抗体

Goat anti-FOXP3/Scurfin (Mouse) Antibody

FOXP3/Scurfin

Foxp3; forkhead box P3; sf; JM2; scurfin; scurfy; RP23-54C14.1; OTTMUSP00000017952; OTTMUSP00000017961; OTTMUSP00000017962; Foxp3 antibody; forkhead box P3 antibody; sf antibody; JM2 antibody; scurfin antibody; scurfy antibody; RP23-54C14.1 antibody; OTTMUSP00000017952 antibody; OTTMUSP00000017961 antibody; OTTMUSP00000017962 antibody; Scurfin; FOXP3 / Scurfin (Mouse)

forkhead box protein P3; Forkhead box protein P3; forkhead box protein P3; forkhead box P3; Scurfin

Foxp3

Foxp3; Foxp3; sf; JM2; scurfin

FOXP3_MOUSE

多克隆

山羊

Tested: Mouse; Expected from sequence similarity: Mouse, Rat

429

KRSQRPNKCSNP

通过硫酸铵沉淀和用免疫多肽抗原亲和层析从山羊血清中纯化得到的

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

100ug specific antibody in 200ul

Aliquot and store at -20 degree C. Minimize freezing and thawing.

肽酶联免疫吸附测定(EIA), 免疫组化(免疫组化)

Peptide ELISA: Antibody detection limit dilution 1: 4000. Immunohistochemistry: In paraffin embedded Mouse Thymus shows nuclear staining in some patches of thymocytes. Recommended concentration, 2-4ug/ml.

Immunogen: Peptide with sequence KRSQRPNKCSNP, from the C Terminus of the protein sequence according to NP_473380.1. Epitope: C Terminus

16905075

NP_473380.1

NM_054039.2

47,346 Da

炎症性肠病(IBD)通路(842778);炎症性肠病(IBD)通路(842797)

The protein encoded by this gene is a member of the forkhead/winged-helix family of transcriptional regulators. Defects in this gene result in the scurfy phenotype (sf). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

FOXP3: Probable transcription factor. Plays a critical role in the control of immune response. Interacts with IKZF3. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Transcription factor; Cell cycle regulation; DNA-binding; C2H2-type zinc finger protein. Cellular Component: cytoplasm; intracellular; nucleus. Molecular Function: DNA binding; histone acetyltransferase binding; histone deacetylase binding; metal ion binding; NFAT protein binding; nucleic acid binding; protein binding; protein homodimerization activity; RNA polymerase II transcription factor activity, enhancer binding; sequence-specific DNA binding; transcription corepressor activity; transcription factor activity. Biological Process: B cell homeostasis; CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation; CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment; cytokine production; inhibition of CREB transcription factor; inhibition of NF-kappaB transcription factor; myeloid cell homeostasis; negative regulation of cell proliferation; negative regulation of chronic inflammatory response; negative regulation of cytokine biosynthetic process; negative regulation of cytokine secretion; negative regulation of histone acetylation; negative regulation of histone deacetylation; negative regulation of immune response; negative regulation of inflammatory response; negative regulation of interferon-gamma biosynthetic process; negative regulation of interferon-gamma production; negative regulation of interleukin-10 production; negative regulation of interleukin-17 production; negative regulation of interleukin-2 biosynthetic process; negative regulation of interleukin-2 production; negative regulation of interleukin-4 production; negative regulation of interleukin-5 production; negative regulation of interleukin-6 production; negative regulation of isotype switching to IgE isotypes; negative regulation of lymphocyte proliferation; negative regulation of T cell cytokine production; negative regulation of T cell proliferation; negative regulation of transcription factor activity; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; negative regulation of tumor necrosis factor production; positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation; positive regulation of histone acetylation; positive regulation of immature T cell proliferation in the thymus; positive regulation of interleukin-4 production; positive regulation of peripheral T cell tolerance induction; positive regulation of regulatory T cell differentiation; positive regulation of T cell anergy; positive regulation of T cell tolerance induction; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; positive regulation of transforming growth factor-beta1 production; regulation of immunoglobulin production; regulation of isotype switching to IgG isotypes; regulation of T cell anergy; regulation of transcription from RNA polymerase II promoter; regulation of transcription, DNA-dependent; regulatory T cell differentiation; T cell activation; T cell mediated immunity; T cell receptor signaling pathway; tolerance induction; tolerance induction to self antigen; transcription, DNA-dependent

0.1毫克

300美元