抗体

山羊抗NMDAR2B/GRIN2B抗体

MBS420388

0.1毫克

300美元

多克隆

山羊

未共轭

人类, 小鼠, 大鼠, 狗

免疫印迹, 酶免疫法

抗体

山羊抗NMDAR2B/GRIN2B抗体

NMDAR2B/GRIN2B

GRIN2B; NMDAR2B; glutamate receptor, ionotropic, N-methyl D-aspartate 2B; HGNC: 4586; NR2B; hNR3; N-methyl-D-aspartate receptor subunit 2B; GRIN2B antibody; NMDAR2B antibody; glutamate receptor; ionotropic; N-methyl D-aspartate 2B antibody; HGNC: 4586 antibody; NR2B antibody; hNR3 antibody; N-methyl-D-aspartate receptor subunit 2B antibody; NMDAR2B / GRIN2B

N-methyl-D-aspartate receptor subunit 2B; Glutamate receptor ionotropic, NMDA 2B; glutamate receptor ionotropic, NMDA 2B; glutamate ionotropic receptor NMDA type subunit 2B; Glutamate [NMDA] receptor subunit epsilon-2; N-methyl D-aspartate receptor subtype 2B; NMDAR2B; NR2B; N-methyl-D-aspartate receptor subunit 3; NR3; hNR3

GRIN2B

NMDAR2B

GRIN2B;GRIN2B;MRD6;NR2B;hNR3;EIEE27;GluN2B;NMDAR2B;NMDAR2B;GluN2B;NMDAR2B;NR2B;NR3;hNR3

NMDE2_HUMAN

多克隆

山羊

Tested: Rat; Expected from sequence similarity: Human, Mouse, Rat, Dog

1484

KDAHEKDDFHHLS

通过硫酸铵沉淀和用免疫多肽抗原亲和层析从山羊血清中纯化得到的

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

100ug specific antibody in 200ul

Aliquot and store at -20 degree C. Minimize freezing and thawing.

肽酶联免疫吸附测定(EIA), 免疫印迹(免疫印迹)

Peptide ELISA: Antibody detection limit dilution 1: 16000. Western Blot: Approx 170kDa band observed in Rat Brain lysates (calculated MW of 166kDa according to NP_000825.1). Recommended concentration: 2-4ug/ml.

Immunogen: Peptide with sequence C-KDAHEKDDFHHLS, from the internal region of the protein sequence according to NP_000825.1. Epitope: Internal region

4504127

NP_000825.1

NM_000834.2

166,367 Da

ARMS-mediated Activation Pathway (1269471); Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway (1268798); Alcoholism Pathway (585563); Alcoholism Pathway (587116); Alzheimer's Disease Pathway (83097); Alzheimer's Disease Pathway (509); Alzheimers Disease Pathway (672448); Amphetamine Addiction Pathway (547607); Amphetamine Addiction Pathway (550546); Amyotrophic Lateral Sclerosis (ALS) Pathway (83099)

N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA receptor channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of three different subunits: NR1 (GRIN1), NR2 (GRIN2A, GRIN2B, GRIN2C, or GRIN2D) and NR3 (GRIN3A or GRIN3B). The NR2 subunit acts as the agonist binding site for glutamate. This receptor is the predominant excitatory neurotransmitter receptor in the mammalian brain. [provided by RefSeq, Jul 2008]

NMDAR2B: an NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. Plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. Mediates neuronal functions in glutamate neurotransmission. In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death. Protein type: Channel, ligand-gated; Membrane protein, multi-pass; Membrane protein, integral; Channel, calcium. Chromosomal Location of Human Ortholog: 12p12. Cellular Component: cell junction; cell surface; integral to plasma membrane; intracellular; N-methyl-D-aspartate selective glutamate receptor complex; neuron projection; plasma membrane; postsynaptic membrane. Molecular Function: extracellular-glutamate-gated ion channel activity; glycine binding; N-methyl-D-aspartate selective glutamate receptor activity; protein binding; Ras guanyl-nucleotide exchange factor activity; zinc ion binding. Biological Process: ephrin receptor signaling pathway; glutamate signaling pathway; ionotropic glutamate receptor signaling pathway; learning and/or memory; MAPKKK cascade; positive regulation of GTPase activity; response to ethanol; synaptic transmission; transport. Disease: Epileptic Encephalopathy, Early Infantile, 27; Mental Retardation, Autosomal Dominant 6

0.1毫克

300美元