产品简要
公司名称 :
MyBioSource
产品类型 :
抗体
产品名称 :
山羊抗APOE抗体
目录 :
MBS420446
规格 :
0.1毫克
价格 :
300美元
克隆性 :
多克隆
宿主 :
山羊
共轭标签 :
未共轭
反应物种 :
人类
应用 :
免疫印迹, 免疫组化, 酶免疫法
更多信息或购买 :
产品信息
目录号 :
MBS420446
产品类型 :
抗体
产品全称 :
山羊抗APOE抗体
产品简称 :
ApoE基因
产品名称同义词 :
APOE; AD2; MGC1571; apoprotein; apolipoprotein E; apolipoprotein E3; Alzheimer disease 2 (APOE*E4-associated, late onset); LPG; APOE antibody; AD2 antibody; MGC1571 antibody; apoprotein antibody; apolipoprotein E antibody; apolipoprotein E3 antibody; Alzheimer disease 2 (APOE*E4-associated; late onset) antibody; LPG antibody
其他名称 :
apolipoprotein E isoform b; Apolipoprotein E; apolipoprotein E; apolipoprotein E
产品基因名称 :
ApoE基因
其他基因名称 :
APOE;APOE;AD2;LPG;ApoE基因-E;LDLCQ5;载脂蛋白E
UniProt数据库进入名 :
APOE_HUMAN
克隆性 :
多克隆
宿主 :
山羊
反应物种 :
Tested: Human; Expected from sequence similarity: Human
序列长度 :
317
序列 :
VGTSAAPVPSDNH
纯度 :
通过硫酸铵沉淀和用免疫多肽抗原亲和层析从山羊血清中纯化得到的
形式 :
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
浓度 :
100ug specific antibody in 200ul
储存稳定性 :
Aliquot and store at -20 degree C. Minimize freezing and thawing.
检测过的应用 :
肽酶联免疫吸附测定(EIA), 免疫印迹(免疫印迹), 免疫组化(免疫组化)
应用笔记 :
Peptide ELISA: Antibody detection limit dilution 1: 32000. Immunohistochemistry: In paraffin embedded Human Liver shows extra-cellular staining between hepatocytes. Recommended concentration, 2-4ug/ml. Western Blot: Approx.36kDa band observed in Human Brain lysates (calculated MW of 36.2kDa according to NP_000032.1). Recommended concentration: 0.1-0.3ug/ml.
其它信息1 :
Immunogen: Peptide with sequence C-VGTSAAPVPSDNH, from the C Terminus of the protein sequence according to NP_000032.1. Epitope: C Terminus
NCBI GI登录号 :
4557325
NCBI登录号 :
NP_000032.1
NCBI基因登录号 :
NM_000041.3
NCBI分子量 :
36,154 Da
NCBI信号通路 :
Alzheimer's Disease Pathway (83097); Alzheimer's Disease Pathway (509); Alzheimers Disease Pathway (672448); Binding And Uptake Of Ligands By Scavenger Receptors Pathway (1269897); Chylomicron-mediated Lipid Transport Pathway (1270006); HDL-mediated Lipid Transport Pathway (1270007); Lipid Digestion, Mobilization, And Transport Pathway (1270002); Lipoprotein Metabolism Pathway (1270005); Metabolism Pathway (1269956); Metabolism Of Fat-soluble Vitamins Pathway (1339147)
NCBI总结 :
The protein encoded by this gene is a major apoprotein of the chylomicron. It binds to a specific liver and peripheral cell receptor, and is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. This gene maps to chromosome 19 in a cluster with the related apolipoprotein C1 and C2 genes. Mutations in this gene result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]
UniProt数据库总结 :
APOE: Mediates the binding, internalization, and catabolism of lipoprotein particles. It can serve as a ligand for the LDL (apo B/E) receptor and for the specific apo-E receptor (chylomicron remnant) of hepatic tissues. Defects in APOE are a cause of hyperlipoproteinemia type 3 (HLPP3); also known as familial dysbetalipoproteinemia. Individuals with HLPP3 are clinically characterized by xanthomas, yellowish lipid deposits in the palmar crease, or less specific on tendons and on elbows. The disorder rarely manifests before the third decade in men. In women, it is usually expressed only after the menopause. The vast majority of the patients are homozygous for APOE*2 alleles. More severe cases of HLPP3 have also been observed in individuals heterozygous for rare APOE variants. The influence of APOE on lipid levels is often suggested to have major implications for the risk of coronary artery disease (CAD). Individuals carrying the common APOE*4 variant are at higher risk of CAD. Genetic variations in APOE are associated with Alzheimer disease type 2 (AD2). It is a late-onset neurodegenerative disorder characterized by progressive dementia, loss of cognitive abilities, and deposition of fibrillar amyloid proteins as intraneuronal neurofibrillary tangles, extracellular amyloid plaques and vascular amyloid deposits. The major constituent of these plaques is the neurotoxic amyloid-beta-APP 40-42 peptide (s), derived proteolytically from the transmembrane precursor protein APP by sequential secretase processing. The cytotoxic C-terminal fragments (CTFs) and the caspase-cleaved products such as C31 derived from APP, are also implicated in neuronal death. The APOE*4 allele is genetically associated with the common late onset familial and sporadic forms of Alzheimer disease. Risk for AD increased from 20% to 90% and mean age at onset decreased from 84 to 68 years with increasing number of APOE*4 alleles in 42 families with late onset AD. Thus APOE*4 gene dose is a major risk factor for late onset AD and, in these families, homozygosity for APOE*4 was virtually sufficient to cause AD by age 80. The mechanism by which APOE*4 participates in pathogenesis is not known. Defects in APOE are a cause of sea-blue histiocyte disease (SBHD); also known as sea-blue histiocytosis. This disorder is characterized by splenomegaly, mild thrombocytopenia and, in the bone marrow, numerous histiocytes containing cytoplasmic granules which stain bright blue with the usual hematologic stains. The syndrome is the consequence of an inherited metabolic defect analogous to Gaucher disease and other sphingolipidoses. Defects in APOE are a cause of lipoprotein glomerulopathy (LPG). LPG is an uncommon kidney disease characterized by proteinuria, progressive kidney failure, and distinctive lipoprotein thrombi in glomerular capillaries. It mainly affects people of Japanese and Chinese origin. The disorder has rarely been described in Caucasians. Belongs to the apolipoprotein A1/A4/E family. Protein type: Lipid-binding; Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: 19q13.2. Cellular Component: cell soma; chylomicron; cytoplasm; dendrite; early endosome; endoplasmic reticulum; extracellular matrix; extracellular region; extracellular space; Golgi apparatus; membrane; nucleus; plasma membrane. Molecular Function: antioxidant activity; beta-amyloid binding; cholesterol binding; cholesterol transporter activity; heparin binding; identical protein binding; lipid binding; lipid transporter activity; low-density lipoprotein receptor binding; metal chelating activity; phospholipid binding; protein binding; protein homodimerization activity; tau protein binding. Biological Process: artery morphogenesis; cellular calcium ion homeostasis; cGMP-mediated signaling; cholesterol catabolic process; cholesterol efflux; cholesterol homeostasis; cholesterol metabolic process; cytoskeleton organization and biogenesis; fatty acid homeostasis; G-protein coupled receptor protein signaling pathway; intracellular transport; lipoprotein biosynthetic process; lipoprotein catabolic process; lipoprotein metabolic process; long-chain fatty acid transport; maintenance of cellular localization; negative regulation of blood coagulation; negative regulation of blood vessel endothelial cell migration; negative regulation of cholesterol biosynthetic process; negative regulation of endothelial cell proliferation; negative regulation of inflammatory response; negative regulation of lipid biosynthetic process; negative regulation of MAP kinase activity; negative regulation of neuron apoptosis; neurite regeneration; nitric oxide mediated signal transduction; phospholipid efflux; positive regulation of cGMP biosynthetic process; positive regulation of lipid biosynthetic process; positive regulation of low-density lipoprotein receptor catabolic process; positive regulation of membrane protein ectodomain proteolysis; positive regulation of nitric-oxide synthase activity; protein import; receptor-mediated endocytosis; regulation of axon extension; regulation of Cdc42 protein signal transduction; regulation of gene expression; regulation of neuronal synaptic plasticity; response to dietary excess; response to reactive oxygen species; retinoid metabolic process; reverse cholesterol transport; synaptic transmission, cholinergic; triacylglycerol catabolic process; triacylglycerol metabolic process; vasodilation; virus assembly. Disease: Alzheimer Disease 2; Alzheimer Disease 4; Lipoprotein Glomerulopathy; Macular Degeneration, Age-related, 1; Sea-blue Histiocyte Disease
尺寸1 :
0.1毫克
价格1 :
300美元
更多信息或购买 :
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华,公司愿景是“生物研究试剂的源头”,现在位于圣地亚哥市。