抗体

Goat anti-Farnesoid X receptor/FXR Antibody

MBS420514

0.1毫克

300美元

多克隆

山羊

未共轭

人类, 狗

免疫印迹, 酶免疫法

抗体

Goat anti-Farnesoid X receptor/FXR Antibody

Farnesoid X receptor/FXR

farnesoid X receptor; HRR1; NR1H4; nuclear receptor subfamily 1, group H, member 4; BAR; FXR; HRR-1; RIP14; farnesol receptor HRR-1; farnesoid X receptor antibody; HRR1 antibody; NR1H4 antibody; nuclear receptor subfamily 1; group H; member 4 antibody; BAR antibody; FXR antibody; HRR-1 antibody; RIP14 antibody; farnesol receptor HRR-1 antibody; Farnesoid X receptor; Farnesoid X receptor / FXR

bile acid receptor isoform 2; Bile acid receptor; bile acid receptor; nuclear receptor subfamily 1 group H member 4; Farnesoid X-activated receptor; Farnesol receptor HRR-1; Nuclear receptor subfamily 1 group H member 4; Retinoid X receptor-interacting protein 14; RXR-interacting protein 14

NR1H4

FXR

NR1H4; NR1H4; BAR; FXR; HRR1; HRR-1; RIP14; BAR; FXR; HRR1; RIP14; RXR-interacting protein 14

NR1H4_HUMAN

多克隆

山羊

Tested: Human; Expected from sequence similarity: Human, Dog

472

KSCREKTELTPDQQ

通过硫酸铵沉淀和用免疫多肽抗原亲和层析从山羊血清中纯化得到的

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

100ug specific antibody in 200ul

Aliquot and store at -20 degree C. Minimize freezing and thawing.

肽酶联免疫吸附测定(EIA), 免疫印迹(免疫印迹)

Peptide ELISA: Antibody detection limit dilution 1: 32000. Western Blot: Approx 55kDa band observed in Human Duodenum and Human Lung lysates (calculated MW of 54.4kDa according to NP_005114.1). Recommended concentration: 1-3ug/ml.

Immunogen: Peptide with sequence KSCREKTELTPDQQ, from the internal region of the protein sequence according to NP_005114.1. Epitope: Internal region

4826980

NP_005114.1

NM_005123.3

48,795 Da

Bile Acid And Bile Salt Metabolism Pathway (1270040); Bile Secretion Pathway (193146); Bile Secretion Pathway (193095); Biological Oxidations Pathway (1270189); Cytochrome P450 - Arranged By Substrate Type Pathway (1270191); Drug Induction Of Bile Acid Pathway (698755); Endogenous Sterols Pathway (1270192); Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway (1270010); Gene Expression Pathway (1269649); Generic Transcription Pathway (1269650)

This gene encodes a ligand-activated transcription factor that shares structural features in common with nuclear hormone receptor family members. This protein functions as a receptor for bile acids, and when bound to bile acids, binds to DNA and regulates the expression of genes involved in bile acid synthesis and transport. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Feb 2016]

NR1H4: Ligand-activated transcription factor. Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. Represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) through the induction of NR0B2 or FGF19 expression, via two distinct mechanisms. Activates the intestinal bile acid-binding protein (IBABP). Activates the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 to this locus. Heterodimer of NR1H4 and RXR. After activation by agonist binding, interacts with a coactivator, NCOA1 or NCOA2. Interacts with CARM1 and SMARD1. Belongs to the nuclear hormone receptor family. NR1 subfamily. 4 isoforms of the human protein are produced by alternative splicing. Protein type: DNA-binding; Nuclear receptor. Chromosomal Location of Human Ortholog: 12q23.1. Cellular Component: nucleoplasm. Molecular Function: bile acid binding; ligand-dependent nuclear receptor activity; ligand-dependent nuclear receptor binding; peptide binding; protein binding; retinoid X receptor binding; RNA polymerase II transcription factor activity, enhancer binding; sequence-specific DNA binding; steroid hormone receptor activity; thyroid hormone receptor activity; transcription coactivator activity; transcription corepressor activity; transcription factor activity; zinc ion binding. Biological Process: bile acid and bile salt transport; bile acid metabolic process; gut development; inflammatory response; innate immune response; intracellular receptor-mediated signaling pathway; negative regulation of apoptosis; negative regulation of I-kappaB kinase/NF-kappaB cascade; negative regulation of transcription from RNA polymerase II promoter; Notch signaling pathway; positive regulation of transcription from RNA polymerase II promoter; regulation of carbohydrate metabolic process; response to glucose stimulus; response to lipopolysaccharide; signal transduction; steroid hormone mediated signaling; toll-like receptor 4 signaling pathway; transcription initiation from RNA polymerase II promoter

0.1毫克

300美元