抗体

Goat anti-Nucleophosmin/NPM1 Antibody

MBS420563

0.1毫克

300美元

多克隆

山羊

未共轭

人类, 小鼠, 大鼠, 狗, 牛

免疫印迹, 酶免疫法

抗体

Goat anti-Nucleophosmin/NPM1 Antibody

Nucleophosmin/NPM1

NPM1; NPM; B23; nucleophosmin (nucleolar phosphoprotein B23, numatrin); numatrin; nucleolar phosphoprotein B23; nucleophosmin/nucleoplasmin family, member 1; MGC104254; nucleophosmin 1; NPM1 antibody; NPM antibody; B23 antibody; nucleophosmin (nucleolar phosphoprotein B23; numatrin) antibody; numatrin antibody; nucleolar phosphoprotein B23 antibody; nucleophosmin/nucleoplasmin family; member 1 antibody; MGC104254 antibody; nucleophosmin 1 antibody; Nucleophosmin; Nucleophosmin / NPM1

nucleophosmin isoform 1; Nucleophosmin; nucleophosmin; nucleophosmin (nucleolar phosphoprotein B23, numatrin); Nucleolar phosphoprotein B23; Nucleolar protein NO38; Numatrin

NPM1

NPM1;NPM1;B23;NPM;NPM;NPM

NPM_HUMAN

多克隆

山羊

Tested: Human, Mouse, Rat; Expected from sequence similarity: Human, Mouse, Rat, Dog, Cow

294

QEAIQDLWQWRKSL

通过硫酸铵沉淀和用免疫多肽抗原亲和层析从山羊血清中纯化得到的

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

100ug specific antibody in 200ul

Aliquot and store at -20 degree C. Minimize freezing and thawing.

肽酶联免疫吸附测定(EIA), 免疫印迹(免疫印迹)

Peptide ELISA: Antibody detection limit dilution 1: 8000. Western Blot: Approx 37kDa band observed in lysates of cell lijnes HeLa and NIH3T3 and in Mouse and Rat Spleen lysates (calculated MW of 32.6kDa according to NP_002511.1). Recommended concentration: 0. 03-0.1ug/ml.

Immunogen: Peptide with sequence C-QEAIQDLWQWRKSL, from the C Terminus of the protein sequence according to NP_002511.1; NP_954654.1. Epitope: C Terminus

Note: This antibody is expected to recognise both report isoforms (NP_002511.1; NP_954654.1).

10835063

NP_002511.1

NM_002520.6

28,400 Da

Aurora B Signaling Pathway (138080); BARD1 Signaling Events Pathway (137959); Cell Cycle Pathway (1269741); Chromosome Maintenance Pathway (1269853); Deposition Of New CENPA-containing Nucleosomes At The Centromere Pathway (1269855); Disease Pathway (1268854); Gene Expression Pathway (1269649); Generic Transcription Pathway (1269650); HIF-1-alpha Transcription Factor Network Pathway (138045); HIV Infection Pathway (1269057)

This gene encodes a phosphoprotein which moves between the nucleus and the cytoplasm. The gene product is thought to be involved in several processes including regulation of the ARF/p53 pathway. A number of genes are fusion partners have been characterized, in particular the anaplastic lymphoma kinase gene on chromosome 2. Mutations in this gene are associated with acute myeloid leukemia. More than a dozen pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Nov 2009]

NPM1: a nucleolar protein associated with nucleolar ribonucleoprotein structures and that binds single-stranded nucleic acids. Is a major component of template activating factor (TAF)-III. It plays a role in controlling centrosome duplication, and may function in the assembly and/or transport of the ribosome. Two alternatively spliced isoforms have been described. Protein type: Nucleolus; Translation; RNA-binding; Oncoprotein. Chromosomal Location of Human Ortholog: 5q35.1. Cellular Component: centrosome; cytoplasm; cytosol; focal adhesion; membrane; nucleolus; nucleoplasm; nucleus; ribonucleoprotein complex; spindle pole centrosome. Molecular Function: histone binding; NF-kappaB binding; protein binding; protein heterodimerization activity; protein homodimerization activity; protein kinase binding; protein kinase inhibitor activity; ribosomal large subunit binding; ribosomal small subunit binding; RNA binding; Tat protein binding; transcription coactivator activity; unfolded protein binding. Biological Process: activation of NF-kappaB transcription factor; cell aging; centrosome cycle; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; DNA repair; DNA replication-independent nucleosome assembly at centromere; intracellular protein transport; negative regulation of apoptosis; negative regulation of cell proliferation; nucleocytoplasmic transport; nucleosome assembly; positive regulation of cell proliferation; positive regulation of transcription, DNA-dependent; positive regulation of translation; protein localization; protein oligomerization; regulation of centriole replication; regulation of endodeoxyribonuclease activity; response to stress; ribosome assembly; signal transduction; viral reproduction

0.1毫克

300美元