抗体

山羊抗动力蛋白激活蛋白抗体

MBS420581

0.1毫克

290美元

多克隆

山羊

未共轭

人类, 小鼠, 大鼠

免疫印迹, 免疫组化, 免疫细胞化学, 酶免疫法

抗体

山羊抗动力蛋白激活蛋白抗体

动力蛋白激活蛋白

DCTN1; dynactin 1 (p150; glued homolog; Drosophila); P135; DP-150; DAP-150; p150-glued; p150; Glued (Drosophila) homolog; 150 kDa dynein-associated polypeptide; dynactin 1 (p150; Glued (Drosophila) homolog); HMN7B; OTTHUMP00000202491; dynactin 1; p150; Glued homolog; DCTN1; dynactin 1 (p150, glued homolog, Drosophila); P135; DP-150; DAP-150; p150-glued; p150, Glued (Drosophila) homolog; 150 kDa dynein-associated polypeptide; dynactin 1 (p150, Glued (Drosophila) homolog); HMN7B; OTTHUMP00000202491; dynactin 1; p150, Glued homolog

dynactin subunit 1 isoform 1; Dynactin subunit 1; dynactin subunit 1; 150 kDa dynein-associated polypeptide; dynactin 1 (p150, glued homolog, Drosophila); dynactin 1; 150 kDa dynein-associated polypeptide; DAP-150; DP-150; p135; p150-glued

DCTN1

DCTN1;DCTN1;P135;DP-150;DAP-150;DP-150

DCTN1_HUMAN

多克隆

山羊

人类, 小鼠, 大鼠

1278

QEQLHQLHSRLIS

通过硫酸铵沉淀和用免疫多肽抗原亲和层析从山羊血清中纯化得到的

Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

100ug specific antibody in 200ul

Aliquot and store at -20 degree C. Minimize freezing and thawing.

肽酶联免疫吸附测定(EIA), 免疫印迹(免疫印迹), 免疫组化(免疫组化), 免疫细胞化学(免疫细胞化学)

Immunohistochemistry: In paraffin embedded Human Cerebellum shows pixulate staining of cytoplasm in neuronal cells. In paraffin embedded Human Testis shows cytoplasm staining in cells of the seminiferous tubules. Recommended concentration, 2-4ug/ml. An anonymous customer found positive results in IHC on Human HeLa cells. Western Blot: Approx 150kDa band observed in cell lline A549 and in Human Testis lysates (calculated MW of 142kDa according to NP_004073.2). Recommended for use at 0.5-2ug/ml. An anonymous customer found positive results in WB on Mouse embryonic fibroblasts (MEF cells). An anonymous customer found positive results in WB on Human HeLa cells. Peptide ELISA: antibody detection limit dilution 1:128000. Immunocytochemsitry: An anonymous customer found positive results in ICC on Mouse embryonic fibroblasts (MEF cells).

Epitope: C Terminus. Immunogen: Peptide with sequence C-QEQLHQLHSRLIS, from the C Terminus of the protein sequence according to NP_004073.2; NP_075408.1; NP_001128512.1; NP_001128513.1. Corresponding Immunizing Peptide: Catalog #MBS425873

Important Note: This antibody is expected to recognise all reported isoforms (NP_004073.2; NP_075408.1; NP_001128512.1; NP_001128513.1).

Bupha-Intr T, Haizlip KM, Janssen PM.; Temporal changes in expression of connexin 43 after load-induced hypertrophy in vitro.; Am J Physiol Heart Circ Physiol. 2009 Mar; 296(3):H806-14.; Pubmed 19136602

13259510

NP_004073.2

NM_004082.4

140,887 Da

Adaptive Immune System Pathway 366160!!Cell Cycle Pathway 530733!!Cell Cycle, Mitotic Pathway 105765!!Centrosome Maturation Pathway 105807!!G2/M Transition Pathway 105801!!Huntington's Disease Pathway 83100!!Huntington's Disease Pathway 512!!IRE1alpha Activates Chaperones Pathway 105906!!Immune System Pathway 106386!!Loss Of Nlp From Mitotic Centrosomes Pathway 105811

This gene encodes the largest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. Dynactin is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit interacts with dynein intermediate chain by its domains directly binding to dynein and binds to microtubules via a highly conserved glycine-rich cytoskeleton-associated protein (CAP-Gly) domain in its N-terminus. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. Mutations in this gene cause distal hereditary motor neuronopathy type VIIB (HMN7B) which is also known as distal spinal and bulbar muscular atrophy (dSBMA). [provided by RefSeq, Oct 2008]

0.1毫克

290美元