产品简要
公司名称 :
MyBioSource
产品类型 :
抗体
产品名称 :
山羊抗TCF2/VHNF1抗体
目录 :
MBS420628
规格 :
0.1毫克
价格 :
300美元
克隆性 :
多克隆
宿主 :
山羊
共轭标签 :
未共轭
反应物种 :
人类, 小鼠, 大鼠, , , 斑马鱼
应用 :
免疫印迹, 免疫细胞化学, 酶免疫法
更多信息或购买 :
产品信息
目录号 :
MBS420628
产品类型 :
抗体
产品全称 :
山羊抗TCF2/VHNF1抗体
产品简称 :
TCF2/VHNF1
产品名称同义词 :
TCF2; VHNF1; transcription factor 2, hepatic LF-B3 variant hepatic nuclear factor; FJHN; HNF1B; HNF1beta; HNF2; LFB3; MODY5; transcription factor 2; TCF2 antibody; VHNF1 antibody; transcription factor 2; hepatic LF-B3 variant hepatic nuclear factor antibody; FJHN antibody; HNF1B antibody; HNF1beta antibody; HNF2 antibody; LFB3 antibody; MODY5 antibody; transcription factor 2 antibody; TCF2 / VHNF1
其他名称 :
hepatocyte nuclear factor 1-beta isoform 1; Hepatocyte nuclear factor 1-beta; hepatocyte nuclear factor 1-beta; HNF1 homeobox B; Homeoprotein LFB3; Transcription factor 2; TCF-2; Variant hepatic nuclear factor 1; vHNF1
产品基因名称 :
HNF1B
产品基因名称同义词 :
TCF2;VHNF1
其他基因名称 :
HNF1B;HNF1B;FJHN;HNF2;LFB3;TCF2;HPC11;LF-B3;MODY5;TCF-2;VHNF1;HNF-1B;HNF1beta;HNF-1-beta;TCF2;HNF-1-beta;HNF-1B;TCF-2;vHNF1
UniProt数据库进入名 :
HNF1B_HUMAN
克隆性 :
多克隆
宿主 :
山羊
反应物种 :
Tested: Human; Expected from sequence similarity: Human, Mouse, Rat, Dog, Pig, Cow, Zebrafish
序列长度 :
557
序列 :
QAYDRQKNPSKEER
纯度 :
通过硫酸铵沉淀和用免疫多肽抗原亲和层析从山羊血清中纯化得到的
形式 :
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
浓度 :
100ug specific antibody in 200ul
储存稳定性 :
Aliquot and store at -20 degree C. Minimize freezing and thawing.
检测过的应用 :
肽酶联免疫吸附测定(EIA), 免疫印迹(免疫印迹), 免疫细胞化学(免疫细胞化学)
应用笔记 :
Peptide ELISA: Antibody detection limit dilution 1: 64000. Immunocytochemistry: An anonymous customer found positive results in ICC on Human primitive gut tube from human embryonic stem cells.
其它信息1 :
Immunogen: Peptide with sequence C-QAYDRQKNPSKEER, from the internal region of the protein sequence according to NP_000449.1; NP_001159395.1. Epitope: Internal region
其他信息2 :
Note: This antibody is expected to recognize both reported isoforms (NP_000449.1; NP_001159395.1). This product may cross-react with HNF1A.
NCBI GI登录号 :
4507397
NCBI登录号 :
NP_000449.1
NCBI基因登录号 :
NM_000458.3
NCBI分子量 :
46,907 Da
NCBI信号通路 :
Developmental Biology Pathway (1270302); Maturity Onset Diabetes Of The Young Pathway (83096); Maturity Onset Diabetes Of The Young Pathway (508); Regulation Of Beta-cell Development Pathway (1270337); Regulation Of Gene Expression In Early Pancreatic Precursor Cells Pathway (1270338); Regulation Of Gene Expression In Late Stage (branching Morphogenesis) Pancreatic Bud Precursor Cells Pathway (1270339)
NCBI总结 :
This gene encodes a member of the homeodomain-containing superfamily of transcription factors. The protein binds to DNA as either a homodimer, or a heterodimer with the related protein hepatocyte nuclear factor 1-alpha. The gene has been shown to function in nephron development, and regulates development of the embryonic pancreas. Mutations in this gene result in renal cysts and diabetes syndrome and noninsulin-dependent diabetes mellitus, and expression of this gene is altered in some types of cancer. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]
UniProt数据库总结 :
TCF2: Transcription factor, probably binds to the inverted palindrome 5'-GTTAATNATTAAC-3'. Defects in HNF1B are the cause of renal cysts and diabetes syndrome (RCAD); also called maturity-onset diabetes of the young type 5 (MODY5) or familial hypoplastic glomerulocystic kidney disease (GCKD). RCAD is an autosomal dominant disorder comprising non-diabetic renal disease resulting from abnormal renal development, and diabetes, which in some cases occurs earlier than age 25 years and is thus consistent with a diagnosis of maturity-onset diabetes of the young (MODY5). The renal disease is highly variable and includes renal cysts, glomerular tufts, aberrant nephrogenesis, primitive tubules, irregular collecting systems, oligomeganephronia, enlarged renal pelves, abnormal calyces, small kidney, single kidney, horseshoe kidney, and hyperuricemic nephropathy. Defects in HNF1B may be rare genetic risk factor contributing to the development of non-insulin-dependent diabetes mellitus (NIDDM). NIDDM is characterized by an autosomal dominant mode of inheritance, onset during adulthood and insulin resistance. Defects in HNF1B may be a cause of susceptibility to prostate cancer hereditary type 11 (HPC11). It is a condition associated with familial predisposition to cancer of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma. Belongs to the HNF1 homeobox family. 3 isoforms of the human protein are produced by alternative splicing. Protein type: DNA-binding; Transcription factor. Chromosomal Location of Human Ortholog: 17q12. Cellular Component: nucleoplasm; nucleus; transcription factor complex. Molecular Function: DNA binding; protein binding; protein complex binding; protein heterodimerization activity; protein homodimerization activity; RNA polymerase II transcription factor activity, enhancer binding; sequence-specific DNA binding; transcription factor activity. Biological Process: anterior/posterior pattern formation; branching morphogenesis of a tube; circadian regulation of gene expression; embryonic digestive tract morphogenesis; endocrine pancreas development; endodermal cell fate specification; epithelial cell proliferation; genitalia development; hindbrain development; inner cell mass cell differentiation; insulin secretion; kidney development; negative regulation of transcription from RNA polymerase II promoter; Notch signaling pathway; positive regulation of transcription, DNA-dependent; pronephros development; protein-DNA complex assembly; regulation of endodermal cell fate specification; regulation of Wnt receptor signaling pathway; response to drug; response to glucose stimulus; response to organic cyclic substance; transcription, DNA-dependent. Disease: Diabetes Mellitus, Noninsulin-dependent; Renal Cell Carcinoma, Nonpapillary; Renal Cysts And Diabetes Syndrome
尺寸1 :
0.1毫克
价格1 :
300美元
更多信息或购买 :
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华,公司愿景是“生物研究试剂的源头”,现在位于圣地亚哥市。