产品简要
公司名称 :
MyBioSource
产品类型 :
抗体
产品名称 :
山羊抗AGTR1/AT1抗体
目录 :
MBS420667
规格 :
0.1毫克
价格 :
300美元
克隆性 :
多克隆
宿主 :
山羊
共轭标签 :
未共轭
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 酶免疫法
更多信息或购买 :
产品信息
目录号 :
MBS420667
产品类型 :
抗体
产品全称 :
山羊抗AGTR1/AT1抗体
产品简称 :
AGTR1/AT1
产品名称同义词 :
AGTR1;AT1;血管紧张素Ⅱ受体, 类型1;AG2S;AGTR1A;AGTR1B;AT1B;AT2R1;AT2R1A;AT2R1B;HAT1R;血管紧张素受体1;血管紧张素受体1B;类型1B血管紧张素Ⅱ受体;AGTR1抗体;AT1抗体;血管紧张素Ⅱ受体;类型1抗体;AG2S抗体;AGTR1A抗体;AGTR1B抗体;AT1B抗体;AT2R1抗体;AT2R1A抗体;AT2R1B抗体;HAT1R抗体;血管紧张素受体1抗体;血管紧张素受体1B抗体;类型1B血管紧张素Ⅱ受体抗体;AGTR1/AT1
其他名称 :
type-1 angiotensin II receptor isoform 1; Type-1 angiotensin II receptor; type-1 angiotensin II receptor; angiotensin II receptor type 1; AT1AR; AT1BR; Angiotensin II type-1 receptor; AT1
产品基因名称 :
AGTR1
产品基因名称同义词 :
AT1
其他基因名称 :
AGTR1;AGTR1;AT1;AG2S;AT1B;AT1R;AT1AR;AT1BR;AT2R1;HAT1R;AGTR1B;AGTR1A;AGTR1B;AT2R1;AT2R1B;AT1
UniProt数据库进入名 :
AGTR1_HUMAN
克隆性 :
多克隆
宿主 :
山羊
反应物种 :
Tested: Human, Mouse, Rat; Expected from sequence similarity: Human, Mouse, Rat
序列长度 :
359
序列 :
EIQKNKPRNDDIFK
纯度 :
通过硫酸铵沉淀和用免疫多肽抗原亲和层析从山羊血清中纯化得到的
形式 :
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
浓度 :
100ug specific antibody in 200ul
储存稳定性 :
Aliquot and store at -20 degree C. Minimize freezing and thawing.
检测过的应用 :
肽酶联免疫吸附测定(EIA), 免疫印迹(免疫印迹)
应用笔记 :
Peptide ELISA: Antibody detection limit dilution 1: 32000. Western Blot: Approx 38kDa band observed in Liver lysates of Human, Mouse and Rat (calculated MW of 41.1kDa according to NP_000676.1, NP_004826.2, NP_033611.1, NP_114038.1 and NP_114438.1). Recommended concentration: 0.3-1ug/ml.
其它信息1 :
Immunogen: Peptide with sequence C-EIQKNKPRNDDIFK, from the internal region of the protein sequence according to NP_000676.1; NP_004826.2; NP_033611.1; NP_114038.1; NP_114438.1. Epitope: Internal region
其他信息2 :
Note: All reported variants represent identical protein (NP_000676.1, NP_004826.2, NP_033611.1, NP_114038.1 and NP_114438.1).
NCBI GI登录号 :
4501997
NCBI登录号 :
NP_000676.1
NCBI基因登录号 :
NM_000685.4
NCBI分子量 :
41,061 Da
NCBI信号通路 :
ACE Inhibitor Pathway (198763); AGE-RAGE Signaling Pathway In Diabetic Complications (1319988); AGE-RAGE Signaling Pathway In Diabetic Complications (1319775); Adrenergic Signaling In Cardiomyocytes Pathway (908257); Adrenergic Signaling In Cardiomyocytes Pathway (909696); Aldosterone Synthesis And Secretion Pathway (1272485); Aldosterone Synthesis And Secretion Pathway (1285075); Angiopoietin Receptor Tie2-mediated Signaling Pathway (137917); Arf6 Signaling Events Pathway (138034); Calcium Signaling Pathway (83050)
NCBI总结 :
Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. It acts through at least two types of receptors. This gene encodes the type 1 receptor which is thought to mediate the major cardiovascular effects of angiotensin II. This gene may play a role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. It was previously thought that a related gene, denoted as AGTR1B, existed; however, it is now believed that there is only one type 1 receptor gene in humans. Multiple alternatively spliced transcript variants have been reported for this gene. [provided by RefSeq, Jul 2012]
UniProt数据库总结 :
AT1: receptor for angiotensin II. Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. Mediates the major cardiovascular effects of angiotensin II. May play role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Protein type: Membrane protein, multi-pass; Membrane protein, integral; Receptor, GPCR; GPCR, family 1. Chromosomal Location of Human Ortholog: 3q24. Cellular Component: integral to membrane; integral to plasma membrane; intracellular; plasma membrane. Molecular Function: angiotensin type I receptor activity; angiotensin type II receptor activity; bradykinin receptor binding; protein binding; protein heterodimerization activity. Biological Process: calcium-mediated signaling; elevation of cytosolic calcium ion concentration; elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); G-protein coupled receptor protein signaling pathway; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); kidney development; positive regulation of cellular protein metabolic process; positive regulation of inflammatory response; positive regulation of NAD(P)H oxidase activity; positive regulation of phospholipase A2 activity; regulation of cell growth; regulation of cell proliferation; regulation of inflammatory response; regulation of systemic arterial blood pressure by renin-angiotensin; regulation of vasoconstriction; regulation of vasodilation; renin-angiotensin regulation of aldosterone production; renin-angiotensin regulation of blood vessel size; Rho protein signal transduction. Disease: Hypertension, Essential; Renal Tubular Dysgenesis
尺寸1 :
0.1毫克
价格1 :
300美元
更多信息或购买 :
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华,公司愿景是“生物研究试剂的源头”,现在位于圣地亚哥市。