抗体

山羊抗REV1L抗体

MBS420843

0.1毫克

300美元

多克隆

山羊

未共轭

人类, 小鼠, 大鼠, 狗, 牛

免疫组化, 酶免疫法

抗体

山羊抗REV1L抗体

REV1L

REV1; REV1L; REV1-like (yeast); REV1; REV1 protein; REV1 (yeast homolog)- like; REV1 homolog (S. cerevisiae); FLJ21523; MGC163283; MGC26225; REV1- like; REV1 antibody; REV1L antibody; REV1-like (yeast) antibody; REV1 antibody; REV1 protein antibody; REV1 (yeast homolog)- like antibody; REV1 homolog (S. cerevisiae) antibody; FLJ21523 antibody; MGC163283 antibody; MGC26225 antibody; REV1- like antibody

DNA repair protein REV1 isoform 1; DNA repair protein REV1; DNA repair protein REV1; REV1, DNA directed polymerase; Alpha integrin-binding protein 80; AIBP80; Rev1-like terminal deoxycytidyl transferase

REV1

REV1L

REV1;REV1;REV1L;AIBP80;REV1L;AIBP80

REV1_HUMAN

多克隆

山羊

Tested: Human; Expected from sequence similarity: Human, Mouse, Rat, Dog, Cow

1251

VLQQTYGSTLKVT

通过硫酸铵沉淀和用免疫多肽抗原亲和层析从山羊血清中纯化得到的

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

100ug specific antibody in 200ul

Aliquot and store at -20 degree C. Minimize freezing and thawing.

肽酶联免疫吸附测定(EIA), 免疫组化(免疫组化)

Peptide ELISA: Antibody detection limit dilution 1: 8000. Immunohistochemistry: In paraffin embedded Human Testis shows nuclear staining in spermatogonia and spermatocytes. Recommended concentration, 4-6ug/ml. Western Blot: No signal obtained yet but low background observed in MOLT-4 lysates at up to 1.5ug/ml.

Immunogen: Peptide with sequence C-VLQQTYGSTLKVT, from the C Terminus of the protein sequence according to NP_057400.1; NP_001032961.1. Epitope: C Terminus

7706681

NP_057400.1

NM_016316.3

43,649 Da

DNA Damage Bypass Pathway (1270367); DNA Repair Pathway (1270350); Fanconi Anemia Pathway (377262); Fanconi Anemia Pathway (377128); Termination Of Translesion DNA Synthesis Pathway (1270374); Translesion Synthesis By POLI Pathway (1270373); Translesion Synthesis By POLK Pathway (1270372); Translesion Synthesis By REV1 Pathway (1270370); Translesion Synthesis By Y Family DNA Polymerases Bypasses Lesions On DNA Template Pathway (1270369)

This gene encodes a protein with similarity to the S. cerevisiae mutagenesis protein Rev1. The Rev1 proteins contain a BRCT domain, which is important in protein-protein interactions. A suggested role for the human Rev1-like protein is as a scaffold that recruits DNA polymerases involved in translesion synthesis (TLS) of damaged DNA. [provided by RefSeq, Mar 2016]

REV1L: Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents. Belongs to the DNA polymerase type-Y family. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Transferase; EC 2.7.7.-; DNA repair, damage. Chromosomal Location of Human Ortholog: 2q11.1-q11.2. Cellular Component: nucleoplasm. Molecular Function: damaged DNA binding; deoxycytidyl transferase activity; metal ion binding; protein binding. Biological Process: bypass DNA synthesis; DNA replication; error-prone postreplication DNA repair; response to UV

0.1毫克

300美元