抗体

山羊抗NMDA受体1/GRIN1抗体

MBS420877

0.1毫克

300美元

多克隆

山羊

未共轭

人类, 小鼠, 大鼠, 狗

免疫印迹, 酶免疫法

抗体

山羊抗NMDA受体1/GRIN1抗体

NMDA受体1/GRIN1

GRIN1; NMDA receptor 1; glutamate receptor, ionotropic, N-methyl D-aspartate 1; NMDA1; NMDAR1; NR1; N-methyl-D-aspartate receptor channel, subunit zeta-1; glutamate [NMDA] receptor subunit zeta 1; GRIN1 antibody; NMDA receptor 1 antibody; glutamate receptor; ionotropic; N-methyl D-aspartate 1 antibody; NMDA1 antibody; NMDAR1 antibody; NR1 antibody; N-methyl-D-aspartate receptor channel; subunit zeta-1 antibody; glutamate [NMDA] receptor subunit zeta 1 antibody; NMDA receptor 1 / GRIN1

glutamate receptor ionotropic, NMDA 1 isoform GluN1-4a; Glutamate receptor ionotropic, NMDA 1; glutamate receptor ionotropic, NMDA 1; glutamate ionotropic receptor NMDA type subunit 1; Glutamate [NMDA] receptor subunit zeta-1; N-methyl-D-aspartate receptor subunit NR1; NMD-R1

GRIN1

NMDA

GRIN1;GRIN1;NR1;MRD8;GluN1;NMDA1;NMD-R1;NMDAR1;NMDAR1;GluN1;NMD-R1

NMDZ1_HUMAN

多克隆

山羊

Tested: Rat; Expected from sequence similarity: Human, Mouse, Rat, Dog

885

TQERVNNSNKKE

通过硫酸铵沉淀和用免疫多肽抗原亲和层析从山羊血清中纯化得到的

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

100ug specific antibody in 200ul

Aliquot and store at -20 degree C. Minimize freezing and thawing.

肽酶联免疫吸附测定(EIA), 免疫印迹(免疫印迹)

肽ELISA:抗体检测限稀释1:1000

Immunogen: Peptide with sequence C-TQERVNNSNKKE, from the internal region of the protein sequence according to NP_000823.4; NP_067544.1; NP_015566.1. Epitope: Internal region

Note: This antibody is expected to recognise all three reported isoforms (NP_000823.4; NP_067544.1; NP_015566.1).

11496971

NP_000823.4

NM_000832.6

101,851 Da

ARMS-mediated Activation Pathway (1269471); Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway (1268798); Alcoholism Pathway (585563); Alcoholism Pathway (587116); Alzheimer's Disease Pathway (83097); Alzheimer's Disease Pathway (509); Alzheimers Disease Pathway (672448); Amphetamine Addiction Pathway (547607); Amphetamine Addiction Pathway (550546); Amyotrophic Lateral Sclerosis (ALS) Pathway (83099)

The protein encoded by this gene is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel. These subunits play a key role in the plasticity of synapses, which is believed to underlie memory and learning. Cell-specific factors are thought to control expression of different isoforms, possibly contributing to the functional diversity of the subunits. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008]

NMDAR1: a subunit of N-methyl-D-aspartate (NMDA) receptors, members of the glutamate receptor channel superfamily. Possesses high calcium permeability and voltage-dependent sensitivity to magnesium and is modulated by glycine. Plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. Mediates neuronal functions in glutamate neurotransmission. Three alternatively-spliced isoforms have been described. Protein type: Membrane protein, integral; Channel, ligand-gated; Membrane protein, multi-pass; Channel, calcium. Chromosomal Location of Human Ortholog: 9q34.3. Cellular Component: cell junction; cell soma; cell surface; dendrite; dendritic spine; endoplasmic reticulum; excitatory synapse; integral to plasma membrane; N-methyl-D-aspartate selective glutamate receptor complex; neuron projection; plasma membrane; postsynaptic density; postsynaptic membrane; synapse; synaptic vesicle; terminal button. Molecular Function: calcium channel activity; calcium ion binding; calmodulin binding; enzyme binding; extracellular-glutamate-gated ion channel activity; glutamate binding; glutamate receptor binding; glycine binding; N-methyl-D-aspartate selective glutamate receptor activity; neurotransmitter binding; protein binding; protein heterodimerization activity; Ras guanyl-nucleotide exchange factor activity; voltage-gated cation channel activity. Biological Process: adult locomotory behavior; calcium ion homeostasis; cation transport; cellular calcium ion homeostasis; cerebral cortex development; conditioned taste aversion; ephrin receptor signaling pathway; ionotropic glutamate receptor signaling pathway; long-term memory; male mating behavior; MAPKKK cascade; negative regulation of neuron apoptosis; olfactory learning; pons maturation; positive regulation of apoptosis; positive regulation of GTPase activity; positive regulation of transcription from RNA polymerase II promoter; prepulse inhibition; propylene metabolic process; protein tetramerization; regulation of axonogenesis; regulation of dendrite morphogenesis; regulation of excitatory postsynaptic membrane potential; regulation of long-term neuronal synaptic plasticity; regulation of membrane potential; regulation of respiratory gaseous exchange; regulation of synaptogenesis; respiratory gaseous exchange; response to amphetamine; response to calcium ion; response to ethanol; response to morphine; rhythmic process; sensory perception of pain; social behavior; suckling behavior; synaptic transmission; synaptic transmission, glutamatergic; visual learning. Disease: Mental Retardation, Autosomal Dominant 8

0.1毫克

300美元