产品简要
公司名称 :
MyBioSource
产品类型 :
抗体
产品名称 :
山羊抗ITGAM/CD11B抗体
目录 :
MBS420973
规格 :
0.1毫克
价格 :
305美元
克隆性 :
多克隆
宿主 :
山羊
共轭标签 :
未共轭
反应物种 :
人类
应用 :
免疫印迹, 免疫组化, 酶免疫法
更多信息或购买 :
图像
图像 1 :
Immunofluorescence analysis of paraformaldehyde fixed U937 cells, permeabilized with 0.15% Triton.Primary incubation 1hr (10ug/ml) followed by Alexa Fluor 488 secondary antibody (4ug/ml), showing cytoplasmic staining. The nuclear stain is DAPI (blue). Negative control: Unimmunized goat IgG (10ug/ml) followed by AlexaFluor 488 secondary antibody (4ug/ml)
图像 2 :
(2ug/ml) staining of paraffin embedded Human Brain. Steamed antigen retrieval with Tris/EDTA buffer pH 9, HRP-staining.
产品信息
目录号 :
MBS420973
产品类型 :
抗体
产品全称 :
山羊抗ITGAM/CD11B抗体
产品简称 :
[ITGAM/CD11B]
产品名称同义词 :
[ITGAM; integrin, alpha M (complement component 3 receptor 3 subunit); CD11B; CR3A; MAC-1; MAC1A; MGC117044; MO1A; Integrin, alpha-M (complement component receptor-3, alpha); antigen CD11B (p170); macrophage antigen, alpha polypeptide; antigen CD11b (p; ITGAM antibody; integrin; alpha M (complement component 3 receptor 3 subunit) antibody; CD11B antibody; CR3A antibody; MAC-1 antibody; MAC1A antibody; MGC117044 antibody; MO1A antibody; Integrin; alpha-M (complement component receptor-3; alpha) antibody; antigen CD11B (p170) antibody; macrophage antigen; alpha polypeptide antibody; antigen CD11b (p170) antibody; complement component receptor 3; alpha antibody; integrin alpha M antibody; integrin; alpha M (complement component receptor 3; alpha) antibody; CD11b (p170); macrophage antigen alpha polypeptide antibody; macrophage antigen alpha polypeptide antibody; neutrophil adherence receptor alpha-M subunit antibody; ITGAM / CD11B]
其他名称 :
[integrin alpha-M isoform 2; Integrin alpha-M; integrin alpha-M; integrin subunit alpha M; CD11 antigen-like family member B; CR-3 alpha chain; Cell surface glycoprotein MAC-1 subunit alpha; Leukocyte adhesion receptor MO1; Neutrophil adherence receptor; CD_antigen: CD11b]
产品基因名称 :
[ITGAM]
产品基因名称同义词 :
[CD11B]
其他基因名称 :
[ITGAM;ITGAM;CR3A;MO1A;CD11B;MAC-1;MAC1A;SLEB6;CD11B;CR3A]
UniProt数据库进入名 :
ITAM_HUMAN
克隆性 :
多克隆
宿主 :
山羊
反应物种 :
Tested: Human. Expected from sequence similarity: Human
序列长度 :
1152
序列 :
RNDGEDSYRTQ
纯度 :
通过硫酸铵沉淀和用免疫多肽抗原亲和层析从山羊血清中纯化得到的
形式 :
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
储存稳定性 :
Aliquot and store at -20°C. Minimize freezing and thawing.
检测过的应用 :
肽酶联免疫吸附测定(EIA), 免疫印迹(免疫印迹), 免疫组化(免疫组化)
应用笔记 :
Peptide ELISA: antibody detection limit dilution 1:32000. Immunofluorescence: Strong expression of the protein seen in the cytoplasm of U937 cells. Recommended concentration: 10 ug/ml.
image1头 :
免疫荧光(IF)
image2头 :
免疫组化(免疫组化)
其它信息1 :
Immunogen: Peptide with sequence C-RNDGEDSYRTQ, from the internal region of the protein sequence according to NP_000623.2. Epitope: Internal region
其他信息2 :
Note: The immunizing peptide represents part of the extra-cellular domain.
NCBI GI登录号 :
88501734
NCBI登录号 :
NP_000623.2
NCBI基因登录号 :
NM_000632.3
NCBI信号通路 :
Amoebiasis Pathway (167324); Amoebiasis Pathway (167191); Cell Adhesion Molecules (CAMs) Pathway (83069); Cell Adhesion Molecules (CAMs) Pathway (480); Cell Surface Interactions At The Vascular Wall Pathway (1269373); Complement And Coagulation Cascades Pathway (83073); Complement And Coagulation Cascades Pathway (484); Extracellular Matrix Organization Pathway (1270244); Focal Adhesion Pathway (198795); Hematopoietic Cell Lineage Pathway (83078)
NCBI总结 :
This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
UniProt数据库总结 :
ITGAM: a single-pass type I membrane protein of the integrin alpha chain family. Implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. Also known as CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the RGD peptide in C3b. A receptor for fibrinogen, factor X and ICAM1. Heterodimer of an alpha and a beta subunit. Alpha-M associates with beta-2. Predominantly expressed in monocytes and granulocytes. Protein type: Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis. Chromosomal Location of Human Ortholog: 16p11.2. Cellular Component: cell surface; extracellular space; plasma membrane. Molecular Function: glycoprotein binding; protein binding. Biological Process: extracellular matrix organization and biogenesis; leukocyte migration; toll-like receptor 4 signaling pathway. Disease: Systemic Lupus Erythematosus, Susceptibility To, 6
尺寸1 :
0.1毫克
价格1 :
305美元
更多信息或购买 :
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华，公司愿景是“生物研究试剂的源头”，现在位于圣地亚哥市。