抗体

山羊抗NOTCH2抗体

MBS421069

0.1毫克

225美元

多克隆

山羊

未共轭

人类, 小鼠, 大鼠, 狗, 牛

酶联免疫吸附测定, 酶免疫法

抗体

山羊抗NOTCH2抗体

NOTCH2

NOTCH2; Notch homolog 2 (Drosophila); HGNC: 7882; hN2; Notch (Drosophila) homolog 2; OTTHUMP00000059536; notch 2; AGS2; NOTCH2 antibody; Notch homolog 2 (Drosophila) antibody; HGNC: 7882 antibody; hN2 antibody; Notch (Drosophila) homolog 2 antibody; OTTHUMP00000059536 antibody; notch 2 antibody; AGS2 antibody

neurogenic locus notch homolog protein 2 isoform 1 preproprotein; Neurogenic locus notch homolog protein 2; neurogenic locus notch homolog protein 2; notch 2

NOTCH2

NOTCH2;NOTCH2;hN2;AGS2;HJCYS;N2ICD

NOTC2_HUMAN

多克隆

山羊

Expected from sequence similarity: Human, Mouse, Rat, Dog, Pig, Cow

2471

ERTPSHSGHLQGEH

通过硫酸铵沉淀和用免疫多肽抗原亲和层析从山羊血清中纯化得到的

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

100ug specific antibody in 200ul

Aliquot and store at -20 degree C. Minimize freezing and thawing.

肽酶联免疫吸附测定(EIA)

Peptide ELISA: Antibody detection limit dilution 1: 16000. Western Blot: Preliminary experiments in lysates of human brain, heart, kidney, liver, lung and skeletal muscle gave no specific signal but low background (at antibody concentration up to 1ug/ml).

Immunogen: Peptide with sequence C-ERTPSHSGHLQGEH, from the internal region of the protein sequence according to NP_077719.2. Epitope: Internal region

24041035

NP_077719.2

NM_024408.3

265,405 Da

Defective LFNG Causes SCDO3 Pathway (1383053); Delta-Notch Signaling Pathway (198879); Disease Pathway (1268854); Diseases Associated With O-glycosylation Of Proteins Pathway (1383049); Diseases Of Glycosylation Pathway (1269010); Dorso-ventral Axis Formation Pathway (114227); Dorso-ventral Axis Formation Pathway (472); Gene Expression Pathway (1269649); Generic Transcription Pathway (1269650); MicroRNAs In Cancer Pathway (852705)

This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]

Notch 2: a member of the Notch family. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. Affects the implementation of differentiation, proliferation and apoptotic programs. Cleaved in the trans-Golgi network and presented on the cell surface as a heterodimer. This protein functions as a receptor for the membrane bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBP-J kappa and activates genes of the enhancer of split locus. Protein type: Motility/polarity/chemotaxis; Receptor, misc.; Membrane protein, integral. Chromosomal Location of Human Ortholog: 1p13-p11. Cellular Component: cell surface; endoplasmic reticulum membrane; extracellular region; Golgi membrane; integral to plasma membrane; membrane; nucleoplasm; nucleus; plasma membrane; receptor complex. Molecular Function: calcium ion binding; protein binding; receptor activity. Biological Process: apoptosis; bone remodeling; cell cycle arrest; cell fate determination; cell growth; hemopoiesis; intracellular receptor-mediated signaling pathway; marginal zone B cell differentiation; multicellular organismal development; negative regulation of apoptosis; negative regulation of cell proliferation; nervous system development; Notch signaling pathway; organ morphogenesis; positive regulation of Ras protein signal transduction; regulation of developmental process; regulation of transcription, DNA-dependent; stem cell maintenance; tissue regeneration; transcription initiation from RNA polymerase II promoter. Disease: Alagille Syndrome 2; Hajdu-cheney Syndrome

0.1毫克

225美元