抗体

山羊抗ADAM金属肽酶成员17/TACE抗体

MBS421126

0.1毫克

290美元

多克隆

山羊

未共轭

人类, 小鼠, 大鼠

免疫印迹, 酶免疫法

抗体

山羊抗ADAM金属肽酶成员17/TACE抗体

ADAM金属肽酶成员17/TACE

ADAM17; TACE; a disintegrin and metalloproteinase domain 17 (tumor necrosis factor; alpha; converting enzyme); CSVP; cSVP; CD156b; CD156b; MGC71942; TACE; cSVPADAM metallopeptidase domain 17; TNF-alpha converting enzyme; a disintegrin and metalloproteinase domain 17; a disintegrin and metalloproteinase domain 17 (tumor necrosis factor; alpha; converting enzyme); snake venom-like protease; ADAM metallopeptidase domain 17; ADAM18; CD156B; ADAM metallopeptidase domain 18; snake venom-like protease; tumor necrosis factor; alpha; converting enzyme; TACE; a disintegrin and metalloproteinase domain 17 (tumor necrosis factor, alpha, converting enzyme); CSVP; cSVP; CD156b; CD156b; MGC71942; TACE; cSVPADAM metallopeptidase domain 17; TNF-alpha converting enzyme; a disintegrin and metalloproteinase domain 17; a disintegrin and metalloproteinase domain 17 (tumor necrosis factor, alpha, converting enzyme); snake venom-like protease; ADAM metallopeptidase domain 17; ADAM18; CD156B; ADAM metallopeptidase domain 18; snake venom-like protease; tumor necrosis factor, alpha, converting enzyme

disintegrin and metalloproteinase domain-containing protein 17 preproprotein; Disintegrin and metalloproteinase domain-containing protein 17; disintegrin and metalloproteinase domain-containing protein 17; TNF-alpha convertase; snake venom-like protease; TNF-alpha converting enzyme; ADAM metallopeptidase domain 18; tumor necrosis factor, alpha, converting enzyme; ADAM metallopeptidase domain 17; Snake venom-like protease; TNF-alpha convertase; TNF-alpha-converting enzyme; CD_antigen: CD156b

ADAM金属肽酶成员17

ADAM金属肽酶成员17;ADAM金属肽酶成员17;CSVP;TACE;NISBD;ADAM18;CD156B;NISBD1;CSVP;TACE;ADAM 17

ADA17_HUMAN

多克隆

山羊

人类, 小鼠, 大鼠

824

LQRQNRVDSKETEC

通过硫酸铵沉淀和用免疫多肽抗原亲和层析从山羊血清中纯化得到的

Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

100ug specific antibody in 200ul

Aliquot and store at -20 degree C. Minimize freezing and thawing.

肽酶联免疫吸附测定(EIA), 免疫印迹(免疫印迹)

Western Blot: Approx 100kDa band observed in Human Testis lysates and approx 125kDa in lysates of cell lines Daudi, HeLa and Jurkat (calculated MW of 93.0kDa according to NP_003174.3). The observed molecular weights correspond to earlier findings in literature with different antibodies (Le Gall et al, J Cell Sci. 2010 Nov 15;123(Pt22):3913-22; PMID: 20980382). Recommended concentration: 0.1-0.3ug/ml. Peptide ELISA: antibody detection limit dilution 1:128000.

Epitope: C Terminus. Immunogen: Peptide with sequence LQRQNRVDSKETEC, from the C Terminus of the protein sequence according to NP_003174.3. Corresponding Immunizing Peptide: Catalog #MBS426989

Important Note: This antibody is expected to recognise isoform 1 (represented by NP_003174) and not isoform 2 (represented by NP_068604).

73747889

NP_003174.3

NM_003183.4

78,543 Da

Activated NOTCH1 Transmits Signal To The Nucleus Pathway 576270!!Alzheimer's Disease Pathway 83097!!Alzheimer's Disease Pathway 509!!Alzheimers Disease Pathway 672448!!Apoptosis Pathway 105648!!BDNF Signaling Pathway 712093!!Collagen Degradation Pathway 730309!!Constitutive Signaling By NOTCH1 HD Domain Mutants Pathway 771591!!Constitutive Signaling By NOTCH1 HD+PEST Domain Mutants Pathway 771595!!Constitutive Signaling By NOTCH1 PEST Domain Mutants Pathway 771593

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene functions as a tumor necrosis factor-alpha converting enzyme; binds mitotic arrest deficient 2 protein; and also plays a prominent role in the activation of the Notch signaling pathway. [provided by RefSeq, Jul 2008]

0.1毫克

290美元