产品简要
公司名称 :
MyBioSource
产品类型 :
抗体
产品名称 :
山羊抗雄激素受体抗体
目录 :
MBS421183
规格 :
0.1毫克
价格 :
300美元
克隆性 :
多克隆
宿主 :
山羊
共轭标签 :
未共轭
反应物种 :
人类, 小鼠, 大鼠, ,
应用 :
免疫印迹, 免疫组化, 酶免疫法, 染色质免疫沉淀
更多信息或购买 :
产品信息
目录号 :
MBS421183
产品类型 :
抗体
产品全称 :
山羊抗雄激素受体抗体
产品简称 :
雄激素受体
产品名称同义词 :
AR;雄激素受体;双氢睾酮受体;KD;AIS;TFM;DHTR;SBMA;NR3C4;SMAX1;HUMARA;HYSP1;雄激素受体;双氢睾酮受体;RP11-383C12.1;雄激素受体抗体;双氢睾酮受体抗体;AR抗体;KD抗体;AIS抗体;TFM抗体;DHTR抗体;SBMA抗体;NR3C4抗体;SMAX1抗体;HUMARA抗体;HYSP1抗体;雄激素受体抗体;双氢睾酮受体抗体;RP11-383C12.1抗体;雄激素受体;雄激素受体
其他名称 :
androgen receptor isoform 1; Androgen receptor; androgen receptor; androgen receptor; Dihydrotestosterone receptor; Nuclear receptor subfamily 3 group C member 4
产品基因名称 :
AR
其他基因名称 :
AR;AR;KD;AIS;AR8;TFM;DHTR;SBMA;HYSP1;NR3C4;SMAX1;HUMARA;DHTR;NR3C4
UniProt数据库进入名 :
ANDR_HUMAN
克隆性 :
多克隆
宿主 :
山羊
反应物种 :
Tested: Human; Expected from sequence similarity: Human, Mouse, Rat, Dog, Pig, Cow
序列长度 :
920
序列 :
EVQLGLGRVYPRPPSC
纯度 :
通过硫酸铵沉淀和用免疫多肽抗原亲和层析从山羊血清中纯化得到的
形式 :
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
浓度 :
100ug specific antibody in 200ul
储存稳定性 :
Aliquot and store at -20 degree C. Minimize freezing and thawing.
检测过的应用 :
肽酶联免疫吸附测定(EIA), 免疫印迹(免疫印迹), 免疫组化(免疫组化), 染色质免疫沉淀 (ChIP)
应用笔记 :
Peptide ELISA: Antibody detection limit dilution 1: 64000. Immunohistochemistry: In paraffin embedded Human Prostate shows nuclear staining in the secretory cells of the gland. Recommended concentration, 2-3ug/ml. Western Blot: Approx 95kDa band observed in Human Brain and Human Heart lysates (calculated MW of 99kDa according to NP_000035). Recommended concentration: 0.3-2ug/ml. Chromatin Immunoprecipitation: A six-fold increased presence of the FKBP5 locus observed when comparing the precipitations using this item with non-specific goat IgG to bring down Androgen Receptor in a chromatin lysate from DHT-stimulated HEC50 cells.
其它信息1 :
Immunogen: Peptide with sequence EVQLGLGRVYPRPPSC, from the N Terminus of the protein sequence according to NP_000035.2. Epitope: N Terminus
其他信息2 :
Note: This antibody is expected to recognize isoform 1 (NP_000035.2) only.
NCBI GI登录号 :
21322252
NCBI登录号 :
NP_000035.2
NCBI基因登录号 :
NM_000044.3
NCBI分子量 :
67,659 Da
NCBI信号通路 :
Activated PKN1 Stimulates Transcription Of AR (androgen Receptor) Regulated Genes KLK2 And KLK3 Pathway (1269513); Alpha6-Beta4 Integrin Signaling Pathway (198807); Androgen Receptor Signaling Pathway (198806); Coregulation Of Androgen Receptor Activity Pathway (138085); FOXA1 Transcription Factor Network Pathway (137979); Gene Expression Pathway (1269649); Generic Transcription Pathway (1269650); IL-6 Signaling Pathway (198864); Integrated Breast Cancer Pathway (219801); Integrated Pancreatic Cancer Pathway (711360)
NCBI总结 :
The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
UniProt数据库总结 :
AR: a nuclear hormone receptor and transcription factor. Regulates gene expression and affects cellular proliferation and differentiation in target tissues. Two splice-variant isoforms have been described. Protein type: DNA-binding; Nuclear receptor; Transcription factor. Chromosomal Location of Human Ortholog: Xq12. Cellular Component: cytoplasm; cytosol; nuclear chromatin; nucleoplasm; nucleus; protein complex. Molecular Function: androgen binding; androgen receptor activity; ATPase binding; beta-catenin binding; chromatin binding; DNA binding; enzyme binding; ligand-dependent nuclear receptor activity; protein binding; protein dimerization activity; receptor binding; transcription factor activity; transcription factor binding; zinc ion binding. Biological Process: activation of NF-kappaB transcription factor; androgen receptor signaling pathway; cell growth; cell proliferation; cell-cell signaling; intracellular receptor-mediated signaling pathway; negative regulation of cell proliferation; negative regulation of integrin biosynthetic process; positive regulation of cell differentiation; positive regulation of cell proliferation; positive regulation of integrin biosynthetic process; positive regulation of phosphorylation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase III promoter; positive regulation of transcription, DNA-dependent; prostate gland development; protein oligomerization; sex differentiation; signal transduction; transcription initiation from RNA polymerase II promoter; transcription, DNA-dependent; transport. Disease: Androgen Insensitivity Syndrome; Androgen Insensitivity, Partial; Hypospadias 1, X-linked; Prostate Cancer; Spinal And Bulbar Muscular Atrophy, X-linked 1
尺寸1 :
0.1毫克
价格1 :
300美元
更多信息或购买 :
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华,公司愿景是“生物研究试剂的源头”,现在位于圣地亚哥市。