抗体

山羊抗NCF1/p47phox抗体

MBS421184

0.1毫克

300美元

多克隆

山羊

未共轭

人类, 小鼠, 大鼠, 牛

免疫印迹, 酶免疫法

抗体

山羊抗NCF1/p47phox抗体

NCF1/p47phox

Goat Anti-p47phox (mouse) Antibody; NCF1; p47phox; FLJ79451; NCF1A; NOXO2; SH3PXD1A; neutrophil cytosolic factor 1; Neutrophil cytosolic factor-1 (47kD); neutrophil cytosolic factor 1 (47kD, chronic granulomatous disease, autosomal 1); NADPH oxidase organizer 2; NCF1 antibody; p47phox antibody; FLJ79451 antibody; NCF1A antibody; NOXO2 antibody; SH3PXD1A antibody; neutrophil cytosolic factor 1 antibody; Neutrophil cytosolic factor-1 (47kD) antibody; neutrophil cytosolic factor 1 (47kD; chronic granulomatous disease; autosomal 1) antibody; NADPH oxidase organizer 2 antibody; NCF1 / p47phox

neutrophil cytosol factor 1; Neutrophil cytosol factor 1; neutrophil cytosol factor 1; neutrophil cytosolic factor 1; 47 kDa autosomal chronic granulomatous disease protein; 47 kDa neutrophil oxidase factor; NCF-47K; Neutrophil NADPH oxidase factor 1; Nox organizer 2; Nox-organizing protein 2; SH3 and PX domain-containing protein 1A; p47-phox

NCF1

p47phox

NCF1;NCF1;NCF1A;NOXO2;p47phox;SH3PXD1A;NOXO2;SH3PXD1A;NCF-1

NCF1_HUMAN

多克隆

山羊

Tested: Human, Mouse, Pig; Expected from sequence similarity: Human, Mouse, Rat, Rabbit, Pig, Cow

390

SESTKRKLASAV

通过硫酸铵沉淀和用免疫多肽抗原亲和层析从山羊血清中纯化得到的

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

100ug specific antibody in 200ul

Aliquot and store at -20 degree C. Minimize freezing and thawing.

肽酶联免疫吸附测定(EIA), 免疫印迹(免疫印迹)

Peptide ELISA: Antibody detection limit dilution 1: 20000. Western Blot: Approx 48kDa band observed in lysates of cell line U937 and of Mouse Thymus, and 50kDa observed in Pig Spleen lysates (calculated MW of 44.7kDa according to NP_000256.3). Recommended concentration: 0.5-1.5ug/ml.

Immunogen: Peptide with sequence C-SESTKRKLASAV, from the C Terminus of the protein sequence according to NP_000256.3. Epitope: C Terminus

115298672

NP_000256.3

NM_000265.4

30,781 Da

AGE/RAGE Pathway (698754); Adaptive Immune System Pathway (1269171); Antigen Processing-Cross Presentation Pathway (1269195); Chemokine Signaling Pathway (99051); Chemokine Signaling Pathway (96864); Class I MHC Mediated Antigen Processing Presentation Pathway (1269192); Cross-presentation Of Particulate Exogenous Antigens (phagosomes) Pathway (1269196); Fc Gamma R-mediated Phagocytosis Pathway (114228); Fc Gamma R-mediated Phagocytosis Pathway (106590); Immune System Pathway (1269170)

The protein encoded by this gene is a 47 kDa cytosolic subunit of neutrophil NADPH oxidase. This oxidase is a multicomponent enzyme that is activated to produce superoxide anion. Mutations in this gene have been associated with chronic granulomatous disease. [provided by RefSeq, Jul 2008]

p47phox: the 47-kilodalton cytosolic subunit of the multi-protein complex known as NADPH oxidase found in neutrophils. The holo-oxidase produces a burst of superoxide which is delivered to the lumen of the neutrophil phagosome. Contains 2 SH2 domains. Mutations in NCF1, as well as in other NADPH oxidase subunits, can result in chronic granulomatous disease. Protein type: EC 1.-.-.-; Oxidoreductase. Chromosomal Location of Human Ortholog: 7q11.23. Cellular Component: cytosol; extrinsic to membrane; NADPH oxidase complex. Molecular Function: electron carrier activity; phosphatidylinositol-3,4-bisphosphate binding; phosphoinositide binding; protein binding; SH3 domain binding; superoxide-generating NADPH oxidase activity. Biological Process: antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; cell redox homeostasis; cellular defense response; innate immune response; protein targeting to membrane; respiratory burst; superoxide metabolic process; superoxide release; vascular endothelial growth factor receptor signaling pathway. Disease: Granulomatous Disease, Chronic, Autosomal Recessive, Cytochrome B-positive, Type I

0.1毫克

300美元