产品简要
公司名称 :
MyBioSource
产品类型 :
抗体
产品名称 :
山羊抗SRD5A2/5α还原酶2抗体
目录 :
MBS421271
规格 :
0.1毫克
价格 :
300美元
克隆性 :
多克隆
宿主 :
山羊
共轭标签 :
未共轭
反应物种 :
人类
应用 :
免疫印迹, 酶免疫法
更多信息或购买 :
产品信息
目录号 :
MBS421271
产品类型 :
抗体
产品全称 :
山羊抗SRD5A2/5α还原酶2抗体
产品简称 :
SRD5A2/5α还原酶2
产品名称同义词 :
Goat Anti-SRD5A2 Antibody; SRD5A2; steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2); steroid 5-alpha-reductase 2; MGC138457; 3-oxo-5 alpha-steroid 4-dehydrogenase 2; SRD5A2 antibody; steroid-5-alpha-reductase; alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) antibody; steroid 5-alpha-reductase 2 antibody; MGC138457 antibody; 3-oxo-5 alpha-steroid 4-dehydrogenase 2 antibody; 5-alpha reductase 2; SRD5A2 / 5-alpha reductase 2
其他名称 :
3-oxo-5-alpha-steroid 4-dehydrogenase 2; 3-oxo-5-alpha-steroid 4-dehydrogenase 2; 3-oxo-5-alpha-steroid 4-dehydrogenase 2; steroid 5 alpha-reductase 2; 5 alpha-SR2; SR type 2; Steroid 5-alpha-reductase 2; S5AR 2; Type II 5-alpha reductase
产品基因名称 :
SRD5A2
其他基因名称 :
SRD5A2;SRD5A2;S5AR 2
UniProt数据库进入名 :
S5A2_HUMAN
克隆性 :
多克隆
宿主 :
山羊
反应物种 :
Tested: Human; Expected from sequence similarity: Human
序列长度 :
254
序列 :
QVQCQQSPVLAG
纯度 :
通过硫酸铵沉淀和用免疫多肽抗原亲和层析从山羊血清中纯化得到的
形式 :
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
浓度 :
100ug specific antibody in 200ul
储存稳定性 :
Aliquot and store at -20 degree C. Minimize freezing and thawing.
检测过的应用 :
肽酶联免疫吸附测定(EIA), 免疫印迹(免疫印迹)
应用笔记 :
Peptide ELISA: Antibody detection limit dilution 1: 8000. Western Blot: (0.3ug/ml) staining of Human Prostate lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
其它信息1 :
Immunogen: Peptide with sequence QVQCQQSPVLAG, from the N Terminus of the protein sequence according to NP_000339.2. Epitope: N Terminus
NCBI GI登录号 :
39812447
NCBI登录号 :
NP_000339.2
NCBI基因登录号 :
NM_000348.3
NCBI分子量 :
28,393 Da
NCBI信号通路 :
Androgen Biosynthesis Pathway (1270050); Metabolism Pathway (1269956); Metabolism Of Lipids And Lipoproteins Pathway (1270001); Metabolism Of Steroid Hormones Pathway (1270046); Prostate Cancer Pathway (83111); Prostate Cancer Pathway (523); Steroid Hormone Biosynthesis Pathway (82940); Steroid Hormone Biosynthesis Pathway (301); Allopregnanolone Biosynthesis Pathway (1108771); Allopregnanolone Biosynthesis Pathway (1108836)
NCBI总结 :
This gene encodes a microsomal protein expressed at high levels in androgen-sensitive tissues such as the prostate. The encoded protein is active at acidic pH and is sensitive to the 4-azasteroid inhibitor finasteride. Deficiencies in this gene can result in male pseudohermaphroditism, specifically pseudovaginal perineoscrotal hypospadias (PPSH). [provided by RefSeq, Jul 2008]
UniProt数据库总结 :
SRD5A2: Converts testosterone (T) into 5-alpha- dihydrotestosterone (DHT) and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology. Defects in SRD5A2 are the cause of pseudovaginal perineoscrotal hypospadias (PPSH). A form of male pseudohermaphroditism in which 46,XY males show ambiguous genitalia at birth, including perineal hypospadias and a blind perineal pouch, and develop masculinization at puberty. The name of the disorder stems from the finding of a blind-ending perineal opening resembling a vagina and a severely hypospadiac penis with the urethra opening onto the perineum. Belongs to the steroid 5-alpha reductase family. Protein type: EC 1.3.1.22; Lipid Metabolism - androgen and estrogen; Membrane protein, integral; Membrane protein, multi-pass; Oxidoreductase. Chromosomal Location of Human Ortholog: 2p23. Cellular Component: cell soma; endoplasmic reticulum membrane; integral to membrane. Molecular Function: 3-oxo-5-alpha-steroid 4-dehydrogenase activity; amide binding; cholestenone 5-alpha-reductase activity; sterol 5-alpha reductase activity. Biological Process: androgen biosynthetic process; androgen metabolic process; biphenyl metabolic process; cell differentiation; cell-cell signaling; dibenzo-p-dioxin metabolic process; female genitalia development; hippocampus development; hypothalamus development; male genitalia development; male gonad development; phthalate metabolic process; response to drug; response to follicle-stimulating hormone stimulus; response to nutrient levels; response to peptide hormone stimulus; response to testosterone stimulus; steroid catabolic process. Disease: Pseudovaginal Perineoscrotal Hypospadias
尺寸1 :
0.1毫克
价格1 :
300美元
更多信息或购买 :
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华,公司愿景是“生物研究试剂的源头”,现在位于圣地亚哥市。