抗体

山羊抗二肽基肽酶4/CD26抗体

MBS421335

0.1毫克

300美元

多克隆

山羊

未共轭

人类, 小鼠, 大鼠, 狗

免疫印迹, 酶免疫法

抗体

山羊抗二肽基肽酶4/CD26抗体

二肽基肽酶4/CD26

DPP4; CD26; dipeptidyl-peptidase 4 (CD26, adenosine deaminase complexing protein 2); ADABP; ADCP2; DPPIV; TP103; T-cell activation antigen CD26; adenosine deaminase complexing protein 2; dipeptidylpeptidase 4 (CD26, adenosine deaminase complexing prote; DPP4 antibody; CD26 antibody; dipeptidyl-peptidase 4 (CD26; adenosine deaminase complexing protein 2) antibody; ADABP antibody; ADCP2 antibody; DPPIV antibody; TP103 antibody; T-cell activation antigen CD26 antibody; adenosine deaminase complexing protein 2 antibody; dipeptidylpeptidase 4 (CD26; adenosine deaminase complexing protein 2) antibody; dipeptidylpeptidase IV antibody; dipeptidylpeptidase IV (CD26; adenosine deaminase complexing protein 2) antibody; DPP4 / CD26

dipeptidyl peptidase 4; Dipeptidyl peptidase 4; dipeptidyl peptidase 4; dipeptidyl peptidase 4; ADABP; Adenosine deaminase complexing protein 2; ADCP-2

二肽基肽酶4

CD26

二肽基肽酶4;二肽基肽酶4;CD26;ADABP;ADCP2;DPPIV;TP103;ADCP2;CD26;ADCP-2;DPP IV

DPP4_HUMAN

多克隆

山羊

Tested: Rat; Expected from sequence similarity: Human, Mouse, Rat, Dog

766

PPHFDKSKKYP

通过硫酸铵沉淀和用免疫多肽抗原亲和层析从山羊血清中纯化得到的

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

100ug specific antibody in 200ul

Aliquot and store at -20 degree C. Minimize freezing and thawing.

肽酶联免疫吸附测定(EIA), 免疫印迹(免疫印迹)

Peptide ELISA: Antibody detection limit dilution 1: 64000. Western Blot: Approx 110kDa band observed in Rat Lung lysates (calculated MW of 88.3Da according to NP_001926.2). The observed molecular weight of this glycoprotein corresponds to earlier findings in literature with different antibodies (Herrera et al, J Biol Chem.2001 Jun 1;276(22): 19532-9.; PMID: 11278278). Recommended concentration: 0.3-1ug/ml.

Immunogen: Peptide with sequence C-PPHFDKSKKYP, from the internal region of the protein sequence according to NP_001926.2. Epitope: Internal region

18765694

NP_001926.2

NM_001935.3

88,279 Da

Incretin Synthesis, Secretion, And Inactivation Pathway (1268750); Metabolism Of Proteins Pathway (1268677); Peptide Hormone Metabolism Pathway (1268746); Protein Digestion And Absorption Pathway (172847); Protein Digestion And Absorption Pathway (171868); Synthesis, Secretion, And Inactivation Of Glucagon-like Peptide-1 (GLP-1) Pathway (1268751); Synthesis, Secretion, And Inactivation Of Glucose-dependent Insulinotropic Polypeptide (GIP) Pathway (1268752)

The protein encoded by this gene is identical to adenosine deaminase complexing protein-2, and to the T-cell activation antigen CD26. It is an intrinsic membrane glycoprotein and a serine exopeptidase that cleaves X-proline dipeptides from the N-terminus of polypeptides. [provided by RefSeq, Jul 2008]

DPP4: Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF- kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. May be involved in the promotion of lymphatic endothelial cells adhesion, migration and tube formation. When overexpressed, enhanced cell proliferation, a process inhibited by GPC3. Acts also as a serine exopeptidase with a dipeptidyl peptidase activity that regulates various physiological processes by cleaving peptides in the circulation, including many chemokines, mitogenic growth factors, neuropeptides and peptide hormones. Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline. Belongs to the peptidase S9B family. DPPIV subfamily. Protein type: Cell surface; Membrane protein, integral; EC 3.4.14.5; Protease; Cell adhesion. Chromosomal Location of Human Ortholog: 2q24.3. Cellular Component: apical plasma membrane; cell surface; endocytic vesicle; focal adhesion; integral to membrane; intercellular canaliculus; lamellipodium; lipid raft; lysosomal membrane; membrane; plasma membrane. Molecular Function: dipeptidyl-peptidase activity; identical protein binding; protease binding; protein binding; protein homodimerization activity; receptor binding; serine-type endopeptidase activity; serine-type peptidase activity; viral receptor activity. Biological Process: behavioral fear response; endothelial cell migration; entry of virus into host cell; positive regulation of cell proliferation; proteolysis; regulation of cell-cell adhesion mediated by integrin; response to hypoxia; T cell activation; T cell costimulation

0.1毫克

300美元