抗体

山羊抗芳香酶/CYP19A1抗体

MBS421466

0.1毫克

300美元

多克隆

山羊

未共轭

免疫印迹, 酶免疫法

抗体

山羊抗芳香酶/CYP19A1抗体

芳香酶/CYP19A1

CYP19A1; cytochrome P450, family 19, subfamily A, polypeptide 1; ARO; ARO1; CPV1; CYAR; CYP19; MGC104309; P-450AROM; aromataseN: cytochrome P450, family 19; cytochrome P450, subfamily XIX (aromatization of androgens); estrogen synthetase; flavoprotein-li; CYP19A1 antibody; cytochrome P450; family 19; subfamily A; polypeptide 1 antibody; ARO antibody; ARO1 antibody; CPV1 antibody; CYAR antibody; CYP19 antibody; MGC104309 antibody; P-450AROM antibody; aromataseN: cytochrome P450; family 19 antibody; cytochrome P450; subfamily XIX (aromatization of androgens) antibody; estrogen synthetase antibody; flavoprotein-linked monooxygenase antibody; microsomal monooxygenase antibody; Aromatase; Aromatase / CYP19A1

aromatase; Aromatase; aromatase; cytochrome P450 family 19 subfamily A member 1; CYPXIX; Cytochrome P-450AROM; Cytochrome P450 19A1; Estrogen synthase

CYP19A1

CYP19A1;CYP19A1;ARO;ARO1;CPV1;CYAR;CYP19;CYPXIX;P-450AROM;ARO1;CYAR;CYP19

CP19A_HUMAN

多克隆

山羊

Tested: Human; Expected from sequence similarity: Human

503

HDLSLHPDETKN

通过硫酸铵沉淀和用免疫多肽抗原亲和层析从山羊血清中纯化得到的

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

100ug specific antibody in 200ul

Aliquot and store at -20 degree C. Minimize freezing and thawing.

肽酶联免疫吸附测定(EIA), 免疫印迹(免疫印迹)

Peptide ELISA: Antibody detection limit dilution 1: 128000. Western Blot: Approx 50-55kDa band observed in Human Placenta lysates (calculated MW of 57.9kDa according to NP_000094.2 and NP_112503.1). Recommended concentration: 0.1-0.3ug/ml.

Immunogen: Peptide with sequence C-HDLSLHPDETKN, from the internal region of the protein sequence according to NP_000094.2; NP_112503.1. Epitope: Internal region

Note: This antibody is expected to recognise both reported isoforms (NP_000094.2 and NP_112503.1), which are identical

13904858

NP_000094.2

NM_000103.3

24,518 Da

Biological Oxidations Pathway (1270189); C19/C18-Steroid Hormone Biosynthesis, Pregnenolone = Androstenedione = Estrone Pathway (413383); C19/C18-Steroid Hormone Biosynthesis, Pregnenolone = Androstenedione = Estrone Pathway (468268); Cytochrome P450 - Arranged By Substrate Type Pathway (1270191); Endogenous Sterols Pathway (1270192); Estrogen Biosynthesis Pathway (1270051); FSH Signaling Pathway (672455); Integrated Breast Cancer Pathway (219801); Metabolic Pathways (132956); Metabolism Pathway (1269956)

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and catalyzes the last steps of estrogen biosynthesis. Mutations in this gene can result in either increased or decreased aromatase activity; the associated phenotypes suggest that estrogen functions both as a sex steroid hormone and in growth or differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

CYP19A1: Catalyzes the formation of aromatic C18 estrogens from C19 androgens. Belongs to the cytochrome P450 family. Protein type: Lipid Metabolism - androgen and estrogen; EC 1.14.14.14; Oxidoreductase. Chromosomal Location of Human Ortholog: 15q21.1. Cellular Component: endoplasmic reticulum; endoplasmic reticulum membrane; membrane. Molecular Function: electron carrier activity; heme binding; iron ion binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; oxygen binding; steroid hydroxylase activity. Biological Process: androgen metabolic process; estrogen biosynthetic process; negative regulation of chronic inflammatory response; steroid biosynthetic process; sterol metabolic process. Disease: Aromatase Deficiency; Aromatase Excess Syndrome

0.1毫克

300美元