抗体

Goat anti-AIF1/IBA1 (isoform 3) Antibody

MBS421481

0.1毫克

300美元

多克隆

山羊

未共轭

人类, 小鼠, 大鼠, 狗

免疫印迹, 免疫组化, 酶免疫法

抗体

Goat anti-AIF1/IBA1 (isoform 3) Antibody

AIF1/IBA1

Goat Anti-AIF1 / IBA1 (isoforms 1 + 3) Antibody; AIF1; IBA1; allograft inflammatory factor 1; DASS-82G15.2; AIF-1; IRT-1; Em: AF129756.17; interferon gamma responsive transcript; ionized calcium-binding adapter molecule; AIF1 antibody; IBA1 antibody; allograft inflammatory factor 1 antibody; DASS-82G15.2 antibody; AIF-1 antibody; IRT-1 antibody; Em: AF129756.17 antibody; interferon gamma responsive transcript antibody; ionized calcium-binding adapter molecule antibody; AIF1 / IBA1 (isoform 3)

allograft inflammatory factor 1 isoform 3; Allograft inflammatory factor 1; allograft inflammatory factor 1; allograft inflammatory factor 1; Ionized calcium-binding adapter molecule 1; Protein G1

AIF1

AIF1;IBA1

AIF1;AIF1;IBA1;IRT1;AIF-1;IRT-1;G1;IBA1;AIF-1

AIF1_HUMAN

多克隆

山羊

Tested: Human, Mouse; Expected from sequence similarity: Human, Mouse, Rat, Dog

147

NKQFLDDPKYSSDED

通过硫酸铵沉淀和用免疫多肽抗原亲和层析从山羊血清中纯化得到的

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

100ug specific antibody in 200ul

Aliquot and store at -20 degree C. Minimize freezing and thawing.

肽酶联免疫吸附测定(EIA), 免疫印迹(免疫印迹), 免疫组化(免疫组化)

Peptide ELISA: Antibody detection limit dilution 1: 32000. Immunohistochemistry: In paraffin embedded Mouse Brain shows staining of astrocytes. Recommended concentration, 2-4ug/ml. Western Blot: Approx 17kDa band observed in Human Brain (Frontal Cortex) and Peripheral Blood Lymphocytes lysates (calculated MW of 16.7kDa according to NP_001614.3). Recommended concentration: 0.5-1.5ug/ml.

Immunogen: Peptide with sequence C-NKQFLDDPKYSSDED, from the internal region of the protein sequence according to NP_001614.3. Epitope: Internal region

Note: This antibody is expected to recognise isoform 3 (NP_001614.3) only.

14574568

NP_001614.3

NM_001623.4

14,617 Da

脊髓损伤通路(739007)

This gene encodes a protein that binds actin and calcium. This gene is induced by cytokines and interferon and may promote macrophage activation and growth of vascular smooth muscle cells and T-lymphocytes. Polymorphisms in this gene may be associated with systemic sclerosis. Alternative splicing results in multiple transcript variants, but the full-length and coding nature of some of these variants is not certain. [provided by RefSeq, Jan 2016]

AIF1: Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. May play a role in macrophage activation and function. Promotes the proliferation of vascular smooth muscle cells and of T- lymphocytes. Enhances lymphocyte migration. Plays a role in vascular inflammation. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Cytoskeletal. Chromosomal Location of Human Ortholog: 6p21.3. Cellular Component: actin filament; cytoplasm; cytosol; lamellipodium; nucleus; perikaryon; perinuclear region of cytoplasm; phagocytic cup. Molecular Function: actin filament binding; calcium ion binding. Biological Process: actin filament bundle formation; actin filament polymerization; cellular response to extracellular stimulus; cellular response to hormone stimulus; inflammatory response; microglial cell activation; negative regulation of apoptosis; negative regulation of smooth muscle cell proliferation; phagocytosis, engulfment; positive regulation of muscle hyperplasia; positive regulation of nitric oxide biosynthetic process; positive regulation of protein amino acid phosphorylation; positive regulation of smooth muscle cell proliferation; positive regulation of T cell proliferation; Rac protein signal transduction; response to axon injury; response to electrical stimulus; response to glucocorticoid stimulus

0.1毫克

300美元