抗体

山羊抗酪氨酸羟化酶抗体

MBS421729

0.1毫克

305美元

多克隆

山羊

未共轭

人类, 大鼠, 狗

免疫组化, 酶免疫法

抗体

山羊抗酪氨酸羟化酶抗体

[酪氨酸羟化酶]

[TH;酪氨酸羟化酶;HGNC:11782;TYH;DYT14;DYT5b;张力障碍14;酪氨酸3单加氧酶]

[tyrosine 3-monooxygenase isoform a; Tyrosine 3-monooxygenase; tyrosine 3-monooxygenase; tyrosine hydroxylase; Tyrosine 3-hydroxylase; TH]

[TH]

[TH;TH;TYH;DYT14;DYT5b;TYH;TH]

TY3H_HUMAN

多克隆

山羊

Tested: Human; Expected from sequence similarity: Human, Rat, Dog

通过硫酸铵沉淀和用免疫多肽抗原亲和层析从山羊血清中纯化得到的

Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

Aliquot and store at -20°C. Minimize freezing and thawing.

肽酶联免疫吸附测定(EIA), 免疫组化(免疫组化)

Peptide ELISA: Antibody detection limit dilution 1: 8000. Immunohistochemistry: Cryosections of Human Hypothalamus. Recommended dilution range between 1:1000 and 1:10,0000.

试验数据

Immunogen: Peptide with sequence C-VQDELDTLAHAL, from the C Terminus of the protein sequence according to NP_954986.2; NP_000351.2; NP_954987.2.

Note: This antibody is expected to recognize all three reported isoforms (as represented by NP_954986.2; NP_000351.2; NP_954987.2).

88900501

NP_954986.2

NM_199292.2

ATF-2 Transcription Factor Network Pathway (138006); Alcoholism Pathway (585563); Alcoholism Pathway (587116); Alpha-synuclein Signaling Pathway (137913); Amine-derived Hormones Pathway (1270175); Amphetamine Addiction Pathway (547607); Amphetamine Addiction Pathway (550546); Biogenic Amine Synthesis Pathway (198793); Catecholamine Biosynthesis Pathway (1270176); Catecholamine Biosynthesis, Tyrosine = Dopamine = Noradrenaline = Adrenaline Pathway (413357)

The protein encoded by this gene is involved in the conversion of tyrosine to dopamine. It is the rate-limiting enzyme in the synthesis of catecholamines, hence plays a key role in the physiology of adrenergic neurons. Mutations in this gene have been associated with autosomal recessive Segawa syndrome. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jul 2008]

TH: an enzyme involved in the conversion of phenylalanine to dopamine. As the rate-limiting enzyme in the synthesis of catecholamines, tyrosine hydroxylase has a key role in the physiology of adrenergic neurons. Four splice variant isoforms have been described. Protein type: Endoplasmic reticulum; Oxidoreductase; Vesicle; Amino Acid Metabolism - tyrosine; Mitochondrial; EC 1.14.16.2. Chromosomal Location of Human Ortholog: 11p15.5. Cellular Component: cytoplasm; cytoplasmic vesicle; cytosol; dendrite; internal side of plasma membrane; melanosome membrane; mitochondrion; neuron projection; nucleus; perikaryon; smooth endoplasmic reticulum; synaptic vesicle; terminal button. Molecular Function: amino acid binding; dopamine binding; enzyme binding; ferric iron binding; ferrous iron binding; oxygen binding; protein binding; protein domain specific binding; tyrosine 3-monooxygenase activity. Biological Process: anatomical structure morphogenesis; catecholamine biosynthetic process; cerebral cortex development; circadian sleep/wake cycle; dopamine biosynthetic process; dopamine biosynthetic process from tyrosine; eating behavior; embryonic camera-type eye morphogenesis; epinephrine biosynthetic process; eye photoreceptor cell development; fatty acid metabolic process; glycoside metabolic process; heart development; heart morphogenesis; isoquinoline alkaloid metabolic process; learning; locomotory behavior; mating behavior; memory; multicellular organismal aging; neurotransmitter biosynthetic process; norepinephrine biosynthetic process; organ morphogenesis; phthalate metabolic process; phytoalexin metabolic process; pigmentation; regulation of heart contraction; response to activity; response to amphetamine; response to corticosterone stimulus; response to electrical stimulus; response to estradiol stimulus; response to ethanol; response to ether; response to herbicide; response to hypoxia; response to light stimulus; response to lipopolysaccharide; response to nutrient levels; response to peptide hormone stimulus; response to pyrethroid; response to salt stress; response to water deprivation; response to zinc ion; sensory perception of sound; social behavior; sphingolipid metabolic process; synaptic transmission, dopaminergic; synaptic vesicle amine transport; terpene metabolic process; visual perception. Disease: Segawa Syndrome, Autosomal Recessive

0.1毫克

305美元