抗体

山羊抗COL4A6抗体

MBS421733

0.1毫克

225美元

多克隆

山羊

未共轭

酶联免疫吸附测定, 酶免疫法

抗体

山羊抗COL4A6抗体

COL4A6

COL4A6; collagen, type IV, alpha 6; MGC88184; OTTHUMP00000023834; OTTHUMP00000023835; collagen IV, alpha-6 polypeptide; collagen alpha 6 type IV; collagen of basement membrane, alpha-6; dJ889N15.4 (Collagen Alpha 6(IV)); type IV alpha 6 collagen; COL4A6 antibody; collagen; type IV; alpha 6 antibody; MGC88184 antibody; OTTHUMP00000023834 antibody; OTTHUMP00000023835 antibody; collagen IV; alpha-6 polypeptide antibody; collagen alpha 6 type IV antibody; collagen of basement membrane; alpha-6 antibody; dJ889N15.4 (Collagen Alpha 6(IV)) antibody; type IV alpha 6 collagen antibody

collagen alpha-6(IV) chain isoform A; Collagen alpha-6(IV) chain; collagen alpha-6(IV) chain; collagen type IV alpha 6

COL4A6

COL4A6;COL4A6;DFNX6;DELXq22.3;CXDELq22.3

CO4A6_HUMAN

多克隆

山羊

Expected from sequence similarity: Human

1691

PSPEFETETLHNKES

通过硫酸铵沉淀和用免疫多肽抗原亲和层析从山羊血清中纯化得到的

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

100ug specific antibody in 200ul

Aliquot and store at -20 degree C. Minimize freezing and thawing.

肽酶联免疫吸附测定(EIA)

Peptide ELISA: Antibody detection limit dilution 1: 32000. Western Blot: Preliminary experiments gave an approx 20kDa band in Human Heart, Kidney and Skeletal Muscle lysates after 0.3 ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 164kDa according to NP_001838.2 and NP_378667.1. The 20kDa band was successfully blocked by incubation with the immunizing peptide.

Immunogen: Peptide with sequence C-PSPEFETETLHNKES, from the internal region of the protein sequence according to NP_001838.2; NP_378667.1. Epitope: Internal region

Note: This antibody is expected to recognize both reported isoforms (NP_001838.2; NP_378667.1).

148536823

NP_001838.2

NM_001847.3

163,629 Da

AGE-RAGE Signaling Pathway In Diabetic Complications (1319988); AGE-RAGE Signaling Pathway In Diabetic Complications (1319775); Amoebiasis Pathway (167324); Amoebiasis Pathway (167191); Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway (1270247); Collagen Biosynthesis And Modifying Enzymes Pathway (1270246); Collagen Formation Pathway (1270245); ECM-receptor Interaction Pathway (83068); ECM-receptor Interaction Pathway (479); Extracellular Matrix Organization Pathway (1270244)

This gene encodes one of the six subunits of type IV collagen, the major structural component of basement membranes. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene, alpha 5 type IV collagen, so that the gene pair shares a common promoter. Deletions in the alpha 5 gene that extend into the alpha 6 gene result in diffuse leiomyomatosis accompanying the X-linked Alport syndrome caused by the deletion in the alpha 5 gene. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2013]

COL4A6: Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. Deletions covering the N-terminal regions of COL4A5 and COL4A6, which are localized in a head-to-head manner, are found in the chromosome Xq22.3 centromeric deletion syndrome. This results in a phenotype with features of diffuse leiomyomatosis and Alport syndrome (DL-ATS). Belongs to the type IV collagen family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Extracellular matrix; Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: Xq22. Cellular Component: collagen type IV; endoplasmic reticulum lumen; extracellular region. Molecular Function: extracellular matrix structural constituent. Biological Process: cell adhesion; collagen catabolic process; extracellular matrix organization and biogenesis. Disease: Deafness, X-linked 6

0.1毫克

225美元