山羊抗CHRNB2抗体 | MyBioSource MBS421737 产品信息

产品简要

公司名称 :

MyBioSource

产品类型 :

抗体

产品名称 :

山羊抗CHRNB2抗体

MBS421737

规格 :

0.1毫克

价格 :

300美元

克隆性 :

多克隆

宿主 :

山羊

共轭标签 :

未共轭

反应物种 :

人类, 小鼠, 大鼠, 狗, 牛

应用 :

免疫印迹, 酶免疫法

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产品信息

目录号 :

MBS421737

产品类型 :

抗体

产品全称 :

山羊抗CHRNB2抗体

产品简称 :

CHRNB2

产品名称同义词 :

CHRNB2; cholinergic receptor, nicotinic, beta 2 (neuronal); EFNL3; nAChRB2; cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal); neuronal nicotinic acetylcholine receptor beta 2; CHRNB2 antibody; cholinergic receptor; nicotinic; beta 2 (neuronal) antibody; EFNL3 antibody; nAChRB2 antibody; cholinergic receptor; nicotinic; beta polypeptide 2 (neuronal) antibody; neuronal nicotinic acetylcholine receptor beta 2 antibody

其他名称 :

neuronal acetylcholine receptor subunit beta-2; Neuronal acetylcholine receptor subunit beta-2; neuronal acetylcholine receptor subunit beta-2; cholinergic receptor nicotinic beta 2 subunit

产品基因名称 :

CHRNB2

其他基因名称 :

CHRNB2;CHRNB2;EFNL3;nAChRB2

UniProt数据库进入名 :

ACHB2_HUMAN

克隆性 :

多克隆

宿主 :

山羊

反应物种 :

Tested: Human; Expected from sequence similarity: Human, Mouse, Rat, Dog, Pig, Cow

序列长度 :

502

序列 :

QPRHHCARQRLR

纯度 :

通过硫酸铵沉淀和用免疫多肽抗原亲和层析从山羊血清中纯化得到的

形式 :

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

浓度 :

100ug specific antibody in 200ul

储存稳定性 :

Aliquot and store at -20 degree C. Minimize freezing and thawing.

检测过的应用 :

肽酶联免疫吸附测定(EIA), 免疫印迹(免疫印迹)

应用笔记 :

Peptide ELISA: Antibody detection limit dilution 1: 64000. Western Blot: approx. 48 kDa band observed in Human Brain (Cerebellum, Cerebral Cortex) lysates (calculated MW of 57. 0 kDa according to NP_000739.1). The observed molecular weight corresponds to earlier findings with different antibodies from other commercial sources. Recommended concentration: 1-3ug/ml.

其它信息1 :

Immunogen: Peptide with sequence QPRHHCARQRLR, from the internal region of the protein sequence according to NP_000739.1. Epitope: Internal region

NCBI GI登录号 :

4502833

NCBI登录号 :

NP_000739.1

NCBI基因登录号 :

NM_000748.2

NCBI分子量 :

57,019 Da

NCBI信号通路 :

Acetylcholine Binding And Downstream Events Pathway (1268787); Activation Of Nicotinic Acetylcholine Receptors Pathway (1268788); Cholinergic Synapse Pathway (217716); Highly Calcium Permeable Nicotinic Acetylcholine Receptors Pathway (1268790); Highly Calcium Permeable Postsynaptic Nicotinic Acetylcholine Receptors Pathway (1268793); Highly Sodium Permeable Acetylcholine Nicotinic Receptors Pathway (1268791); Neuroactive Ligand-receptor Interaction Pathway (83053); Neuroactive Ligand-receptor Interaction Pathway (462); Neuronal System Pathway (1268763); Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Pathway (1268786)

NCBI总结 :

Neuronal acetylcholine receptors are homo- or heteropentameric complexes composed of homologous alpha and beta subunits. They belong to a superfamily of ligand-gated ion channels which allow the flow of sodium and potassium across the plasma membrane in response to ligands such as acetylcholine and nicotine. This gene encodes one of several beta subunits. Mutations in this gene are associated with autosomal dominant nocturnal frontal lobe epilepsy. [provided by RefSeq, Jul 2008]

UniProt数据库总结 :

nAChRB2: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. Defects in CHRNB2 are the cause of nocturnal frontal lobe epilepsy type 3 (ENFL3). ENFL3 is an autosomal dominant epilepsy characterized by nocturnal seizures with hyperkinetic automatisms and poorly organized stereotyped movements. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Beta- 2/CHRNB2 sub-subfamily. Protein type: Channel, ligand-gated; Membrane protein, integral; Channel, cation; Membrane protein, multi-pass; Receptor, misc. Chromosomal Location of Human Ortholog: 1q21.3. Cellular Component: cell junction; external side of plasma membrane; integral to membrane; nicotinic acetylcholine-gated receptor-channel complex; plasma membrane; postsynaptic membrane. Molecular Function: acetylcholine binding; acetylcholine receptor activity; drug binding; ligand-gated ion channel activity; nicotinic acetylcholine-activated cation-selective channel activity; protein binding; protein heterodimerization activity. Biological Process: associative learning; B cell activation; behavioral response to nicotine; calcium ion transport; central nervous system projection neuron axonogenesis; cognition; conditioned taste aversion; ion transport; lateral geniculate nucleus development; learning; locomotory behavior; membrane depolarization; memory; negative regulation of action potential; neurological system process; neuromuscular synaptic transmission; optic nerve morphogenesis; positive regulation of B cell proliferation; positive regulation of dopamine secretion; positive regulation of synaptic transmission, dopaminergic; protein heterooligomerization; regulation of action potential; regulation of circadian sleep/wake cycle, non-REM sleep; regulation of circadian sleep/wake cycle, REM sleep; regulation of dendrite morphogenesis; regulation of dopamine metabolic process; regulation of dopamine secretion; regulation of synaptic transmission, dopaminergic; regulation of synaptogenesis; response to cocaine; response to ethanol; response to hypoxia; response to nicotine; sensory perception of pain; sensory perception of sound; signal transduction; smooth muscle contraction; social behavior; synaptic transmission involved in micturition; synaptic transmission, cholinergic; vestibulocochlear nerve development; visual learning; visual perception. Disease: Epilepsy, Nocturnal Frontal Lobe, 3

尺寸1 :

0.1毫克

价格1 :

300美元

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