抗体

山羊抗ETV1抗体

MBS421744

0.1毫克

225美元

多克隆

山羊

未共轭

人类, 小鼠, 大鼠, 狗

酶联免疫吸附测定, 酶免疫法

抗体

山羊抗ETV1抗体

ETV1

ETV1; ets variant gene 1; HGNC: 3490; DKFZp781L0674; ER81; MGC104699; MGC120533; MGC120534; ets variant 1; ETV1 antibody; ets variant gene 1 antibody; HGNC: 3490 antibody; DKFZp781L0674 antibody; ER81 antibody; MGC104699 antibody; MGC120533 antibody; MGC120534 antibody; ets variant 1 antibody

ETS translocation variant 1 isoform a; ETS translocation variant 1; ETS translocation variant 1; ETS variant 1; Ets-related protein 81

ETV1

ETV1;ETV1;ER81;ER81

ETV1_HUMAN

多克隆

山羊

Expected from sequence similarity: Human, Mouse, Rat, Dog

477

PLKIKKEPHSPCSE

通过硫酸铵沉淀和用免疫多肽抗原亲和层析从山羊血清中纯化得到的

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

100ug specific antibody in 200ul

Aliquot and store at -20 degree C. Minimize freezing and thawing.

肽酶联免疫吸附测定(EIA)

Peptide ELISA: Antibody detection limit dilution 1: 8000. Western Blot: Preliminary experiments in lysates in cell line A431 gave no specific signal but low background (at antibody concentration up to 1ug/ml).

Immunogen: Peptide with sequence PLKIKKEPHSPCSE, from the internal region of the protein sequence according to NP_004947.2; NP_001156619.1; NP_001156620.1; NP_001156621.1; NP_001156622.1; NP_001156623.1; NP_001156624.1. Epitope: Internal region

Note: This antidbody is expected to recognise all reported isoforms. Variants (NP_001156620.1; NP_001156621.1) encode the same isoform.

31742534

NP_004947.2

NM_004956.4

50,217 Da

Transcriptional Misregulation In Cancer Pathway (523016); Transcriptional Misregulation In Cancer Pathway (522987); P38 Signaling Mediated By MAPKAP Kinases Pathway (138078)

This gene encodes a member of the ETS (E twenty-six) family of transcription factors. The ETS proteins regulate many target genes that modulate biological processes like cell growth, angiogenesis, migration, proliferation and differentiation. All ETS proteins contain an ETS DNA-binding domain that binds to DNA sequences containing the consensus 5'-CGGA[AT]-3'. The protein encoded by this gene contains a conserved short acidic transactivation domain (TAD) in the N-terminal region, in addition to the ETS DNA-binding domain in the C-terminal region. This gene is involved in chromosomal translocations, which result in multiple fusion proteins including EWS-ETV1 in Erwing sarcoma and at least 10 ETV1 partners (see PMID: 19657377, Table 1) in prostate cancer. In addition to chromosomal rearrangement, this gene is overexpressed in prostate cancer, melanoma and gastrointestinal stromal tumor. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]

ETV1: Transcriptional activator that binds to DNA sequences containing the consensus pentanucleotide 5'-CGGA[AT]-3'. Defects in ETV1 are a cause of Ewing sarcoma (ES). A highly malignant, metastatic, primitive small round cell tumor of bone and soft tissue that affects children and adolescents. It belongs to the Ewing sarcoma family of tumors, a group of morphologically heterogeneous neoplasms that share the same cytogenetic features. They are considered neural tumors derived from cells of the neural crest. Ewing sarcoma represents the less differentiated form of the tumors. A chromosomal aberration involving ETV1 is found in patients with Erwing sarcoma. Translocation t(7;22)(p22;q12) with EWSR1. Belongs to the ETS family. 4 isoforms of the human protein are produced by alternative splicing. Protein type: DNA-binding; Transcription factor; Oncoprotein. Chromosomal Location of Human Ortholog: 7p21.3. Cellular Component: nucleus. Molecular Function: protein binding; transcription factor activity. Biological Process: axon guidance; mechanosensory behavior; muscle development; peripheral nervous system neuron development; positive regulation of transcription from RNA polymerase II promoter; transcription from RNA polymerase II promoter

0.1毫克

225美元