产品简要
公司名称 :
MyBioSource
产品类型 :
抗体
产品名称 :
山羊抗SLC10A2/ASBT抗体
目录 :
MBS421745
规格 :
0.1毫克
价格 :
300美元
克隆性 :
多克隆
宿主 :
山羊
共轭标签 :
未共轭
反应物种 :
人类
应用 :
免疫组化, 酶免疫法
更多信息或购买 :
产品信息
目录号 :
MBS421745
产品类型 :
抗体
产品全称 :
山羊抗SLC10A2/ASBT抗体
产品简称 :
SLC10A2/ASBT
产品名称同义词 :
SLC10A2; ASBT; solute carrier family 10 (sodium/bile acid cotransporter family), member 2; ISBT; NTCP2; OTTHUMP00000040691; ileal apical sodium-dependent bile acid transporter; ileal sodium-dependent bile acid transporter; SLC10A2 antibody; ASBT antibody; solute carrier family 10 (sodium/bile acid cotransporter family); member 2 antibody; ISBT antibody; NTCP2 antibody; OTTHUMP00000040691 antibody; ileal apical sodium-dependent bile acid transporter antibody; ileal sodium-dependent bile acid transporter antibody; SLC10A2 / ASBT
其他名称 :
ileal sodium/bile acid cotransporter; Ileal sodium/bile acid cotransporter; ileal sodium/bile acid cotransporter; solute carrier family 10 member 2; Apical sodium-dependent bile acid transporter; ASBT; Ileal Na(+)/bile acid cotransporter; Ileal sodium-dependent bile acid transporter; IBAT; ISBT; Na(+)-dependent ileal bile acid transporter; Sodium/taurocholate cotransporting polypeptide, ileal; Solute carrier family 10 member 2
产品基因名称 :
SLC10A2
产品基因名称同义词 :
ASBT
其他基因名称 :
SLC10A2;SLC10A2;ASBT;IBAT;ISBT;PBAM;NTCP2;ASBT;ISBT;NTCP2;ASBT;IBAT;ISBT
UniProt数据库进入名 :
NTCP2_HUMAN
克隆性 :
多克隆
宿主 :
山羊
反应物种 :
Tested: Human; Expected from sequence similarity: Human
序列长度 :
348
序列 :
YKANGGFQPDEK
纯度 :
通过硫酸铵沉淀和用免疫多肽抗原亲和层析从山羊血清中纯化得到的
形式 :
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
浓度 :
100ug specific antibody in 200ul
储存稳定性 :
Aliquot and store at -20 degree C. Minimize freezing and thawing.
检测过的应用 :
肽酶联免疫吸附测定(EIA), 免疫组化(免疫组化)
应用笔记 :
Peptide ELISA: Antibody detection limit dilution 1: 16000. Immunohistochemistry: In paraffin embedded Human Small Intestine shows staining of cells in the laminia propria between the intestinal vili. Recommended concentration, 3-6ug/ml. Western Blot: Preliminary experiments gave an approx. 60kDa band in Human Kidney lysates after 0.1ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 37.7kDa according to NP_000443.1. The 60kDa band was successfully blocked by incubation with the immunizing peptide.
其它信息1 :
Immunogen: Peptide with sequence C-YKANGGFQPDEK, from the C Terminus of the protein sequence according to NP_000443.1. Epitope: C Terminus
NCBI GI登录号 :
4506973
NCBI登录号 :
NP_000443.1
NCBI基因登录号 :
NM_000452.2
NCBI分子量 :
37,714 Da
NCBI信号通路 :
Bile Acid And Bile Salt Metabolism Pathway (1270040); Bile Secretion Pathway (193146); Bile Secretion Pathway (193095); Metabolism Pathway (1269956); Metabolism Of Lipids And Lipoproteins Pathway (1270001); Recycling Of Bile Acids And Salts Pathway (1270045)
NCBI总结 :
This gene encodes a sodium/bile acid cotransporter. This transporter is the primary mechanism for uptake of intestinal bile acids by apical cells in the distal ileum. Bile acids are the catabolic product of cholesterol metabolism, so this protein is also critical for cholesterol homeostasis. Mutations in this gene cause primary bile acid malabsorption (PBAM); muatations in this gene may also be associated with other diseases of the liver and intestines, such as familial hypertriglyceridemia (FHTG). [provided by RefSeq, Mar 2010]
UniProt数据库总结 :
ASBT: Plays a critical role in the sodium-dependent reabsorption of bile acids from the lumen of the small intestine. Plays a key role in cholesterol metabolism. Defects in SLC10A2 are a cause of primary bile acid malabsorption (PBAM). PBAM is an idiopathic intestinal disorder associated with congenital diarrhea, steatorrhea, interruption of the enterohepatic circulation of bile acids, and reduced plasma cholesterol levels. Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family. Protein type: Membrane protein, multi-pass; Transporter; Membrane protein, integral. Chromosomal Location of Human Ortholog: 13q33. Cellular Component: apical plasma membrane; integral to plasma membrane; microvillus; plasma membrane. Molecular Function: bile acid:sodium symporter activity. Biological Process: bile acid and bile salt transport; sodium ion transport; transmembrane transport; transport. Disease: Bile Acid Malabsorption, Primary
尺寸1 :
0.1毫克
价格1 :
300美元
更多信息或购买 :
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华,公司愿景是“生物研究试剂的源头”,现在位于圣地亚哥市。