山羊抗SRCAP抗体 | MyBioSource MBS421768 产品信息

产品简要

公司名称 :

MyBioSource

产品类型 :

抗体

产品名称 :

山羊抗SRCAP抗体

MBS421768

规格 :

0.1毫克

价格 :

225美元

克隆性 :

多克隆

宿主 :

山羊

共轭标签 :

未共轭

反应物种 :

人类, 小鼠, 大鼠, 狗

应用 :

酶联免疫吸附测定, 酶免疫法

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产品信息

目录号 :

MBS421768

产品类型 :

抗体

产品全称 :

山羊抗SRCAP抗体

产品简称 :

SRCAP

产品名称同义词 :

Goat Anti-SRCAP (aa309-322) Antibody; SRCAP; Snf2-related CREBBP activator protein; DOMO1; EAF1; FLJ44499; KIAA0309; SWR1; OTTHUMP00000163226; Snf2-related CBP activator protein; Swi2/Snf2-related ATPase homolog, domino homolog 1; SRCAP antibody; Snf2-related CREBBP activator protein antibody; DOMO1 antibody; EAF1 antibody; FLJ44499 antibody; KIAA0309 antibody; SWR1 antibody; OTTHUMP00000163226 antibody; Snf2-related CBP activator protein antibody; Swi2/Snf2-related ATPase homolog; domino homolog 1 antibody

其他名称 :

helicase SRCAP; Helicase SRCAP; helicase SRCAP; Snf2-related CREBBP activator protein; Domino homolog 2; Snf2-related CBP activator

产品基因名称 :

SRCAP

其他基因名称 :

SRCAP;SRCAP;EAF1;FLHS;SWR1;DOMO1;KIAA0309

UniProt数据库进入名 :

SRCAP_HUMAN

克隆性 :

多克隆

宿主 :

山羊

反应物种 :

Expected from sequence similarity: Human, Mouse, Rat, Dog

序列长度 :

3230

序列 :

DEAQNIKNFKSQR

纯度 :

通过硫酸铵沉淀和用免疫多肽抗原亲和层析从山羊血清中纯化得到的

形式 :

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

浓度 :

100ug specific antibody in 200ul

储存稳定性 :

Aliquot and store at -20 degree C. Minimize freezing and thawing.

检测过的应用 :

肽酶联免疫吸附测定(EIA)

应用笔记 :

Peptide ELISA: Antibody detection limit dilution 1: 8000. Western Blot: Preliminary experiments in lysates of cell lines K562 and MOLT4 gave no specific signal but low background (at antibody concentration up to 1ug/ml).

其它信息1 :

Immunogen: Peptide with sequence C-DEAQNIKNFKSQR, from the internal region of the protein sequence according to NP_006653.2. Epitope: Internal region

NCBI GI登录号 :

146219843

NCBI登录号 :

NP_006653.2

NCBI基因登录号 :

NM_006662.2

NCBI分子量 :

327,838 Da

NCBI总结 :

This gene encodes the core catalytic component of the multiprotein chromatin-remodeling SRCAP complex. The encoded protein is an ATPase that is necessary for the incorporation of the histone variant H2A.Z into nucleosomes. It can function as a transcriptional activator in Notch-mediated, CREB-mediated and steroid receptor-mediated transcription. Mutations in this gene cause Floating-Harbor syndrome, a rare disorder characterized by short stature, language deficits and dysmorphic facial features. [provided by RefSeq, Feb 2012]

UniProt数据库总结 :

SRCAP: Catalytic component of the SRCAP complex which mediates the ATP-dependent exchange of histone H2AZ/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. Acts as a coactivator for CREB-mediated transcription, steroid receptor-mediated transcription, and Notch-mediated transcription. Defects in SRCAP are the cause of Floating-Harbor syndrome (FLHS). A rare genetic disorder characterized by proportionate short stature, delayed bone age, delayed speech development, and typical facial features. The face is triangular with deep-set eyes, long eyelashes, bulbous nose, wide columella, short philtrum, and thin lips. Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily. 3 isoforms of the human protein are produced by alternative splicing. Protein type: EC 3.6.4.-; Transcription, coactivator/corepressor; Helicase; EC 3.6.1.-; DNA-binding; Acetyltransferase. Chromosomal Location of Human Ortholog: 16p11.2. Cellular Component: Golgi apparatus; nucleus; perinuclear region of cytoplasm; protein complex. Molecular Function: ATP binding; DNA binding; helicase activity; histone acetyltransferase activity; protein binding; transcription coactivator activity. Biological Process: histone acetylation; regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; viral reproduction. Disease: Floating-harbor Syndrome

尺寸1 :

0.1毫克

价格1 :

225美元

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