山羊抗ERN1/IRE1a抗体 | MyBioSource MBS421918 产品信息

产品简要

公司名称 :

MyBioSource

产品类型 :

抗体

产品名称 :

山羊抗ERN1/IRE1a抗体

MBS421918

规格 :

0.1毫克

价格 :

300美元

克隆性 :

多克隆

宿主 :

山羊

共轭标签 :

未共轭

反应物种 :

人类, 小鼠, 大鼠, 狗, 牛

应用 :

免疫印迹, 酶免疫法

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产品信息

目录号 :

MBS421918

产品类型 :

抗体

产品全称 :

山羊抗ERN1/IRE1a抗体

产品简称 :

ERN1/IRE1a

产品名称同义词 :

Goat Anti-IRE1 / ERN1 Antibody; ERN1; IRE1; endoplasmic reticulum to nucleus signaling 1; FLJ30999; IRE1P; MGC163277; MGC163279; ER to nucleus signalling 1; endoplasmic reticulum to nucleus signalling 1; inositol-requiring 1; protein kinase/endoribonuclease; IRE1a, IRE1-alpha; ERN1 antibody; IRE1 antibody; endoplasmic reticulum to nucleus signaling 1 antibody; FLJ30999 antibody; IRE1P antibody; MGC163277 antibody; MGC163279 antibody; ER to nucleus signalling 1 antibody; endoplasmic reticulum to nucleus signalling 1 antibody; inositol-requiring 1 antibody; protein kinase/endoribonuclease antibody; IRE1a; IRE1-alpha antibody; ERN1 / IRE1a

其他名称 :

serine/threonine-protein kinase/endoribonuclease IRE1; Serine/threonine-protein kinase/endoribonuclease IRE1; serine/threonine-protein kinase/endoribonuclease IRE1; endoplasmic reticulum to nucleus signaling 1; Endoplasmic reticulum-to-nucleus signaling 1; Inositol-requiring protein 1; hIRE1p; Ire1-alpha; IRE1a

产品基因名称 :

ERN1

产品基因名称同义词 :

IRE1a

其他基因名称 :

ERN1;ERN1;IRE1;IRE1P;IRE1a;hIRE1p;hIRE1p;IRE1a

UniProt数据库进入名 :

ERN1_HUMAN

克隆性 :

多克隆

宿主 :

山羊

反应物种 :

Tested: Human; Expected from sequence similarity: Human, Mouse, Rat, Dog, Pig, Cow

序列长度 :

977

序列 :

PNAHGKIKAMISD

纯度 :

通过硫酸铵沉淀和用免疫多肽抗原亲和层析从山羊血清中纯化得到的

形式 :

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

浓度 :

100ug specific antibody in 200ul

储存稳定性 :

Aliquot and store at -20 degree C. Minimize freezing and thawing.

检测过的应用 :

肽酶联免疫吸附测定(EIA), 免疫印迹(免疫印迹)

应用笔记 :

Peptide ELISA: Antibody detection limit dilution 1: 8000. Western Blot: Approx.110kDa band observed in Human Pancreas lysates (calculated MW of 110kDa according to NP_001424.3). Recommended concentration: 0. 03-0.1ug/ml.

其它信息1 :

Immunogen: Peptide with sequence C-PNAHGKIKAMISD, from the internal region of the protein sequence according to NP_001424.3. Epitope: Internal region

NCBI GI登录号 :

153946421

NCBI登录号 :

NP_001424.3

NCBI基因登录号 :

NM_001433.3

NCBI分子量 :

6,649 Da

NCBI信号通路 :

Alzheimer's Disease Pathway (83097); Alzheimer's Disease Pathway (509); Alzheimers Disease Pathway (672448); Apoptosis Pathway (83060); Apoptosis Pathway (470); Corticotropin-releasing Hormone Pathway (920957); IRE1alpha Activates Chaperones Pathway (1268759); Metabolism Of Proteins Pathway (1268677); Non-alcoholic Fatty Liver Disease (NAFLD) Pathway (862188); Non-alcoholic Fatty Liver Disease (NAFLD) Pathway (862314)

NCBI总结 :

The protein encoded by this gene is the ER to nucleus signalling 1 protein, a human homologue of the yeast Ire1 gene product. This protein possesses intrinsic kinase activity and an endoribonuclease activity and it is important in altering gene expression as a response to endoplasmic reticulum-based stress signals. [provided by RefSeq, Jul 2008]

UniProt数据库总结 :

IRE1: a ser/thr protein kinase that possess endonuclease activity. Important in altering gene expression as a response to endoplasmic reticulum based stress signals. Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain, which leads to enzyme auto-activation. The active endoribonuclease domain splices XBP1 mRNA to generate a new C-terminus, converting it into a potent unfolded-protein response transcriptional activator and triggering growth arrest and apoptosis. The kinase domain is activated by trans-autophosphorylation. Kinase activity is required for activation of the endoribonuclease domain. Ubiquitously expressed. High levels observed in pancreatic tissue. Functionally connected with insulin biosynthesis in pancreatic beta cells. Homodimer; disulfide-linked. Dimer formation is driven by hydrophobic interactions within the N-terminal luminal domains and stabilized by disulfide bridges. Also binds HSPA5, a negative regulator of the unfolded protein response. This interaction may disrupt homodimerization and prevent activation of IRE1. Protein type: Chaperone; Apoptosis; Membrane protein, integral; EC 2.7.11.1; Protein kinase, Other; Ribonuclease; Kinase, protein; Endoplasmic reticulum; Protein kinase, Ser/Thr (non-receptor); Other group; IRE family. Chromosomal Location of Human Ortholog: 17q24.2. Cellular Component: cytoplasm; endoplasmic reticulum; endoplasmic reticulum membrane; integral to endoplasmic reticulum membrane; mitochondrion; nuclear inner membrane. Molecular Function: ADP binding; ATP binding; endoribonuclease activity; enzyme binding; Hsp70 protein binding; Hsp90 protein binding; identical protein binding; magnesium ion binding; protein binding; protein homodimerization activity; protein serine/threonine kinase activity. Biological Process: activation of JNK activity; cell cycle arrest; endothelial cell proliferation; mRNA catabolic process; mRNA cleavage; positive regulation of RNA splicing; protein amino acid autophosphorylation; protein amino acid phosphorylation; regulation of macroautophagy; regulation of transcription, DNA-dependent; transcription, DNA-dependent; unfolded protein response, activation of signaling protein activity

尺寸1 :

0.1毫克

价格1 :

300美元

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公司信息