抗体

山羊抗TDP-43抗体

MBS422006

0.1毫克

300美元

多克隆

山羊

未共轭

人类, 小鼠, 狗, 牛

免疫印迹, 酶免疫法

抗体

山羊抗TDP-43抗体

TDP-43

TARDBP;焦油DNA结合蛋白;ALS10;TDP-43;OTTHUMP00000002171;焦油DNA结合蛋白43;TARDBP抗体;焦油DNA结合蛋白抗体;ALS10抗体;TDP-43抗体;OTTHUMP00000002171抗体;焦油DNA结合蛋白43抗体;TDP-43

焦油DNA结合蛋白43;焦油DNA结合蛋白43;焦油DNA结合蛋白43;焦油DNA结合蛋白

TARDBP

TDP-43

TARDBP;TARDBP;ALS10;TDP-43;TDP43;TDP-43

TADBP_HUMAN

多克隆

山羊

Tested: Human, Mouse; Expected from sequence similarity: Human, Mouse, Rat, Dog, Pig, Cow

414

HISNAEPKHNSNRQ

通过硫酸铵沉淀和用免疫多肽抗原亲和层析从山羊血清中纯化得到的

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

100ug specific antibody in 200ul

Aliquot and store at -20 degree C. Minimize freezing and thawing.

肽酶联免疫吸附测定(EIA), 免疫印迹(免疫印迹)

Peptide ELISA: Antibody detection limit dilution 1: 16000. Western Blot: approx. 45kDa band observed in lysates of cell lines Jurkat and NIH3T3 (calculated MW of 44.7kDa according to NP_031401.1). A slightly larger protein is detected in some regions of the brain. Recommended concentration: 0.3-1ug/ml.

Immunogen: Peptide with sequence C-HISNAEPKHNSNRQ, from the internal region of the protein sequence according to NP_031401.1. Epitope: Internal region

6678271

NP_031401.1

NM_007375.3

31,808 Da

HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene is a transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1 transcription. In addition, this protein regulates alternate splicing of the CFTR gene. A similar pseudogene is present on chromosome 20. [provided by RefSeq, Jul 2008]

TARDBP: DNA and RNA-binding protein which regulates transcription and splicing. Involved in the regulation of CFTR splicing. It promotes CFTR exon 9 skipping by binding to the UG repeated motifs in the polymorphic region near the 3'-splice site of this exon. The resulting aberrant splicing is associated with pathological features typical of cystic fibrosis. May also be involved in microRNA biogenesis, apoptosis and cell division. Can repress HIV-1 transcription by binding to the HIV-1 long terminal repeat. Stabilizes the low molecular weight neurofilament (NFL) mRNA through a direct interaction with the 3' UTR. Homodimer. Binds specifically to pyrimidine-rich motifs of TAR DNA and to single stranded TG repeated sequences. Binds to RNA, specifically to UG repeated sequences with a minimun of six contiguous repeats. Interacts with ATNX2; the interaction is RNA-dependent. Ubiquitously expressed. In particular, expression is high in pancreas, placenta, lung, genital tract and spleen. 3 isoforms of the human protein are produced by alternative splicing. Protein type: RNA-binding. Chromosomal Location of Human Ortholog: 1p36.22. Cellular Component: cytoplasm; nuclear speck; nucleoplasm; nucleus; perichromatin fibrils. Molecular Function: double-stranded DNA binding; identical protein binding; mRNA 3'-UTR binding; nucleotide binding; protein binding; RNA binding; transcription factor activity. Biological Process: mRNA processing; negative regulation of protein amino acid phosphorylation; nuclear fragmentation during apoptosis; positive regulation of insulin secretion; positive regulation of transcription from RNA polymerase II promoter; regulation of cell cycle; RNA splicing; transcription from RNA polymerase II promoter. Disease: Amyotrophic Lateral Sclerosis 10, With Or Without Frontotemporal Dementia

0.1毫克

300美元