抗体

山羊抗F2R/PAR1抗体

MBS422062

0.1毫克

300美元

多克隆

山羊

未共轭

免疫印迹, 酶免疫法

抗体

山羊抗F2R/PAR1抗体

F2R/PAR1

F2R;凝血因子II(凝血酶)受体;CF2R;HTR;PAR1;TR;凝血因子II受体;蛋白酶激活受体1;凝血酶受体;F2R抗体;凝血因子II(凝血酶)受体抗体;CF2R抗体;HTR抗体;PAR1抗体;TR抗体;凝血因子II受体抗体;蛋白酶激活受体1抗体;凝血酶受体抗体;F2R/PAR1

proteinase-activated receptor 1 isoform 1; Proteinase-activated receptor 1; proteinase-activated receptor 1; coagulation factor II thrombin receptor; Coagulation factor II receptor; Thrombin receptor

F2R

PAR1

F2R;F2R;TR;HTR;CF2R;PAR1;PAR-1;CF2R;PAR1;TR;PAR-1

PAR1_HUMAN

多克隆

山羊

Tested: Human; Expected from sequence similarity: Human

425

TRARRPESKATNAT

通过硫酸铵沉淀和用免疫多肽抗原亲和层析从山羊血清中纯化得到的

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

100ug specific antibody in 200ul

Aliquot and store at -20 degree C. Minimize freezing and thawing.

肽酶联免疫吸附测定(EIA), 免疫印迹(免疫印迹)

Peptide ELISA: Antibody detection limit dilution 1: 32000. Western Blot: Approx 48kDa band observed in lysates of cell line HeLa (calculated MW of 47.4kDa according to NP_001983.2). Recommended concentration: 0.5-2ug/ml.

Immunogen: Peptide with sequence C-TRARRPESKATNAT, from the Internal region (near N Terminus) of the protein sequence according to NP_001983.2. Epitope: Internal region (near N Terminus)

166362740

NP_001983.2

NM_001992.4

47,441 Da

Calcium Signaling Pathway (83050); Calcium Signaling Pathway (459); Class A/1 (Rhodopsin-like Receptors) Pathway (1269545); Common Pathway Of Fibrin Clot Formation (1269371); Complement And Coagulation Cascades Pathway (198880); Complement And Coagulation Cascades Pathway (83073); Complement And Coagulation Cascades Pathway (484); Endocytosis Pathway (102279); Endocytosis Pathway (102181); Formation Of Fibrin Clot (Clotting Cascade) Pathway (1269368)

Coagulation factor II receptor is a 7-transmembrane receptor involved in the regulation of thrombotic response. Proteolytic cleavage leads to the activation of the receptor. F2R is a G-protein coupled receptor family member. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]

PAR1: a G-protein coupled high-affinity receptor for activated thrombin or trypsin. Coupled to G proteins that stimulate phosphoinositide hydrolysis. Coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelet activation and in vascular development. Protein type: Cell development/differentiation; Membrane protein, integral; Membrane protein, multi-pass; GPCR, family 1; Receptor, GPCR. Chromosomal Location of Human Ortholog: 5q13. Cellular Component: caveola; cell surface; cytosol; early endosome; extracellular region; Golgi apparatus; integral to plasma membrane; late endosome; neuromuscular junction; plasma membrane; postsynaptic membrane. Molecular Function: G-protein alpha-subunit binding; G-protein beta-subunit binding; G-protein coupled receptor activity; protein binding; receptor binding; thrombin receptor activity. Biological Process: activation of MAPKK activity; anatomical structure morphogenesis; blood coagulation; caspase activation; connective tissue replacement during inflammatory response; elevation of cytosolic calcium ion concentration; elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); establishment of synaptic specificity at neuromuscular junction; G-protein coupled receptor protein signaling pathway; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); homeostasis of number of cells within a tissue; inflammatory response; negative regulation of cell proliferation; negative regulation of glomerular filtration; negative regulation of neuron apoptosis; platelet activation; platelet dense granule organization and biogenesis; positive regulation of blood coagulation; positive regulation of calcium ion transport; positive regulation of caspase activity; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of collagen biosynthetic process; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of JAK-STAT cascade; positive regulation of MAPKKK cascade; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of release of sequestered calcium ion into cytosol; positive regulation of Rho protein signal transduction; positive regulation of smooth muscle contraction; positive regulation of transcription, DNA-dependent; positive regulation of vasoconstriction; protein kinase C activation; regulation of blood coagulation; regulation of interleukin-1 beta production; regulation of sensory perception of pain; release of sequestered calcium ion into cytosol; response to lipopolysaccharide; response to wounding; STAT protein nuclear translocation; tyrosine phosphorylation of STAT protein

0.1毫克

300美元