山羊抗KCNN2抗体 | MyBioSource MBS422106 产品信息

产品简要

公司名称 :

MyBioSource

产品类型 :

抗体

产品名称 :

山羊抗KCNN2抗体

MBS422106

规格 :

0.1毫克

价格 :

300美元

克隆性 :

多克隆

宿主 :

山羊

共轭标签 :

未共轭

反应物种 :

人类, 狗

应用 :

免疫印迹, 免疫组化, 酶免疫法

更多信息或购买 :

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产品信息

目录号 :

MBS422106

产品类型 :

抗体

产品全称 :

山羊抗KCNN2抗体

产品简称 :

KCNN2

产品名称同义词 :

KCNN2; potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2; KCa2.2; SK2; SKCA2; hSK2; apamin-sensitive small-conductance Ca2+-activated potassium channel; small conductance calcium-activated potassium channel protein; KCNN2 antibody; potassium intermediate/small conductance calcium-activated channel; subfamily N; member 2 antibody; KCa2.2 antibody; SK2 antibody; SKCA2 antibody; hSK2 antibody; apamin-sensitive small-conductance Ca2+-activated potassium channel antibody; small conductance calcium-activated potassium channel protein 2 antibody

其他名称 :

small conductance calcium-activated potassium channel protein 2 isoform a; Small conductance calcium-activated potassium channel protein 2; small conductance calcium-activated potassium channel protein 2; potassium calcium-activated channel subfamily N member 2; KCa2.2

产品基因名称 :

KCNN2

其他基因名称 :

KCNN2;KCNN2;SK2;hSK2;SKCA2;KCa2.2;SKCa 2;SK2;SKCa 2;SKCa2

UniProt数据库进入名 :

KCNN2_HUMAN

克隆性 :

多克隆

宿主 :

山羊

反应物种 :

Tested: Human; Expected from sequence similarity: Human, Mouse, Rat, Dog, Cow

序列长度 :

579

序列 :

ESYDKHVTYNAER

纯度 :

通过硫酸铵沉淀和用免疫多肽抗原亲和层析从山羊血清中纯化得到的

形式 :

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

浓度 :

100ug specific antibody in 200ul

储存稳定性 :

Aliquot and store at -20 degree C. Minimize freezing and thawing.

检测过的应用 :

肽酶联免疫吸附测定(EIA), 免疫印迹(免疫印迹), 免疫组化(免疫组化)

应用笔记 :

Peptide ELISA: Antibody detection limit dilution 1: 64000. Immunohistochemistry: In paraffin embedded Humam Thyroid Gland shows membranous staining in the epithelial cells. Recommended concentration, 1-2ug/ml. Western Blot: Approx 70kDa and 23kDa bands observed in Human Liver lysates (calculated MW of 63.8kDa according to NP_067627.2 and of 26.3kDa according to NP_740721.1). Recommended concentration: 0.3-1ug/ml.

其它信息1 :

Immunogen: Peptide with sequence C-ESYDKHVTYNAER, from the internal region of the protein sequence according to NP_067627.2; NP_740721.1. Epitope: Internal region

其他信息2 :

Note: This antibody is expected to recognize both isoforms (NP_067627.2; NP_740721.1).

NCBI GI登录号 :

25777645

NCBI登录号 :

NP_067627.2

NCBI基因登录号 :

NM_021614.3

NCBI分子量 :

26,341 Da

NCBI信号通路 :

BDNF Signaling Pathway (712093); Bile Secretion Pathway (193146); Bile Secretion Pathway (193095); Ca2+ Activated K+ Channels Pathway (1268822); Insulin Secretion Pathway (777534); Neuronal System Pathway (1268763); Potassium Channels Pathway (1268821); Serotonergic Synapse Pathway (525336)

NCBI总结 :

Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by this gene is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. This gene is a member of the KCNN family of potassium channel genes. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. Alternate splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2013]

UniProt数据库总结 :

KCNN2: Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin. Belongs to the potassium channel KCNN family. KCa2.2/KCNN2 subfamily. Protein type: Membrane protein, integral; Channel, potassium; Membrane protein, multi-pass. Chromosomal Location of Human Ortholog: 5q22.3. Cellular Component: cell soma; cell surface; dendritic spine; integral to membrane; plasma membrane; smooth endoplasmic reticulum; T-tubule; Z disc. Molecular Function: alpha-actinin binding; calcium-activated potassium channel activity; calmodulin binding; protein domain specific binding; protein homodimerization activity; small conductance calcium-activated potassium channel activity. Biological Process: potassium ion transport

尺寸1 :

0.1毫克

价格1 :

300美元

更多信息或购买 :

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公司信息