免疫印迹, 免疫组化, 酶免疫法
KCNN2; potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2; KCa2.2; SK2; SKCA2; hSK2; apamin-sensitive small-conductance Ca2+-activated potassium channel; small conductance calcium-activated potassium channel protein; KCNN2 antibody; potassium intermediate/small conductance calcium-activated channel; subfamily N; member 2 antibody; KCa2.2 antibody; SK2 antibody; SKCA2 antibody; hSK2 antibody; apamin-sensitive small-conductance Ca2+-activated potassium channel antibody; small conductance calcium-activated potassium channel protein 2 antibody
small conductance calcium-activated potassium channel protein 2 isoform a; Small conductance calcium-activated potassium channel protein 2; small conductance calcium-activated potassium channel protein 2; potassium calcium-activated channel subfamily N member 2; KCa2.2
KCNN2;KCNN2;SK2;hSK2;SKCA2;KCa2.2;SKCa 2;SK2;SKCa 2;SKCa2
Tested: Human; Expected from sequence similarity: Human, Mouse, Rat, Dog, Cow
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
100ug specific antibody in 200ul
Aliquot and store at -20 degree C. Minimize freezing and thawing.
肽酶联免疫吸附测定(EIA), 免疫印迹(免疫印迹), 免疫组化(免疫组化)
Peptide ELISA: Antibody detection limit dilution 1: 64000. Immunohistochemistry: In paraffin embedded Humam Thyroid Gland shows membranous staining in the epithelial cells. Recommended concentration, 1-2ug/ml. Western Blot: Approx 70kDa and 23kDa bands observed in Human Liver lysates (calculated MW of 63.8kDa according to NP_067627.2 and of 26.3kDa according to NP_740721.1). Recommended concentration: 0.3-1ug/ml.
Immunogen: Peptide with sequence C-ESYDKHVTYNAER, from the internal region of the protein sequence according to NP_067627.2; NP_740721.1. Epitope: Internal region
Note: This antibody is expected to recognize both isoforms (NP_067627.2; NP_740721.1).
NCBI GI登录号 :
BDNF Signaling Pathway (712093); Bile Secretion Pathway (193146); Bile Secretion Pathway (193095); Ca2+ Activated K+ Channels Pathway (1268822); Insulin Secretion Pathway (777534); Neuronal System Pathway (1268763); Potassium Channels Pathway (1268821); Serotonergic Synapse Pathway (525336)
Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by this gene is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. This gene is a member of the KCNN family of potassium channel genes. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. Alternate splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2013]
KCNN2: Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin. Belongs to the potassium channel KCNN family. KCa2.2/KCNN2 subfamily. Protein type: Membrane protein, integral; Channel, potassium; Membrane protein, multi-pass. Chromosomal Location of Human Ortholog: 5q22.3. Cellular Component: cell soma; cell surface; dendritic spine; integral to membrane; plasma membrane; smooth endoplasmic reticulum; T-tubule; Z disc. Molecular Function: alpha-actinin binding; calcium-activated potassium channel activity; calmodulin binding; protein domain specific binding; protein homodimerization activity; small conductance calcium-activated potassium channel activity. Biological Process: potassium ion transport
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308