产品简要
公司名称 :
MyBioSource
产品类型 :
抗体
产品名称 :
Goat anti-Granulin/GRN Antibody
目录 :
MBS422188
规格 :
0.1毫克
价格 :
300美元
克隆性 :
多克隆
宿主 :
山羊
共轭标签 :
未共轭
反应物种 :
人类
应用 :
免疫印迹, 酶免疫法
更多信息或购买 :
产品信息
目录号 :
MBS422188
产品类型 :
抗体
产品全称 :
Goat anti-Granulin/GRN Antibody
产品简称 :
Granulin/GRN
产品名称同义词 :
Goat Anti-Progranulin aa248-259 / Granulin-3 Antibody; GRN; granulin; GEP; GP88; PCDGF; PEPI; PGRN; PC cell-derived growth factor; acrogranin; granulin-epithelin; proepithelin; progranulin; GRN antibody; granulin antibody; GEP antibody; GP88 antibody; PCDGF antibody; PEPI antibody; PGRN antibody; PC cell-derived growth factor antibody; acrogranin antibody; granulin-epithelin antibody; proepithelin antibody; progranulin antibody; Granulin; Granulin / GRN
其他名称 :
granulins; Granulins; granulins; granulin; Proepithelin; PEPI
产品基因名称 :
GRN
其他基因名称 :
GRN;GRN;GEP;GP88;PEPI;PGRN;CLN11;PCDGF;PEPI;GP88;糖蛋白88
UniProt数据库进入名 :
GRN_HUMAN
克隆性 :
多克隆
宿主 :
山羊
反应物种 :
Tested: Human; Expected from sequence similarity: Human
序列长度 :
593
序列 :
QSKCLSKENATTD
纯度 :
通过硫酸铵沉淀和用免疫多肽抗原亲和层析从山羊血清中纯化得到的
形式 :
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
浓度 :
100ug specific antibody in 200ul
储存稳定性 :
Aliquot and store at -20 degree C. Minimize freezing and thawing.
检测过的应用 :
肽酶联免疫吸附测定(EIA), 免疫印迹(免疫印迹)
应用笔记 :
Peptide ELISA: Antibody detection limit dilution 1: 8000. Western Blot: Approx. 60kDa band observed in lysates of A549 and HeLa (calculated MW of 63.5kDa according to NP_002078.1). Recommended concentration: 1-3ug/ml.
其它信息1 :
Immunogen: Peptide with sequence QSKCLSKENATTD, from the internal region of the protein sequence according to NP_002078.1. Epitope: Internal region
NCBI GI登录号 :
4504151
NCBI登录号 :
NP_002078.1
NCBI基因登录号 :
NM_002087.3
NCBI分子量 :
44,132 Da
NCBI信号通路 :
Integrated Breast Cancer Pathway (219801)
NCBI总结 :
Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis. [provided by RefSeq, Jul 2008]
UniProt数据库总结 :
GRN: Granulins have possible cytokine-like activity. They may play a role in inflammation, wound repair, and tissue remodeling. Defects in GRN are the cause of ubiquitin-positive frontotemporal dementia (UP-FTD); also known as tau- negative frontotemporal dementia linked to chromosome 17. Frontotemporal dementia (FTD) is the second most common cause of dementia in people under the age of 65 years. It is an autosomal dominant neurodegenerative disease. Defects in GRN are the cause of neuronal ceroid lipofuscinosis type 11 (CLN11). A form of neuronal ceroid lipofuscinosis characterized by rapidly progressive visual loss due to retinal dystrophy, seizures, cerebellar ataxia, and cerebellar atrophy. Cognitive decline may also occur. Neuronal ceroid lipofuscinoses are progressive neurodegenerative, lysosomal storage diseases characterized by intracellular accumulation of autofluorescent liposomal material. Belongs to the granulin family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 17q21.32. Cellular Component: cytosol; extracellular space; intracellular membrane-bound organelle. Molecular Function: cytokine activity; growth factor activity; protein binding. Biological Process: male mating behavior; response to estradiol stimulus; signal transduction; synaptic vesicle endocytosis. Disease: Ceroid Lipofuscinosis, Neuronal, 11; Frontotemporal Lobar Degeneration With Tdp43 Inclusions, Grn-related
尺寸1 :
0.1毫克
价格1 :
300美元
更多信息或购买 :
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华,公司愿景是“生物研究试剂的源头”,现在位于圣地亚哥市。