抗体

山羊抗AMPA1/GLUR1(aa264-277)抗体

MBS422615

0.1毫克

300美元

多克隆

山羊

未共轭

人类, 小鼠, 大鼠, 狗, 牛

免疫印迹, 酶免疫法

抗体

山羊抗AMPA1/GLUR1(aa264-277)抗体

AMPA1/GLUR1

Goat Anti-AMPA1 / GLUR1 Antibody; GRIA1; glutamate receptor, ionotropic, AMPA 1; GLUH1; GLUR1; GLURA; GluA1; HBGR1; MGC133252; AMPA 1; AMPA-selective glutamate receptor 1; gluR-1; gluR-A; gluR-K1; glutamate receptor 1; GRIA1 antibody; glutamate receptor; ionotropic; AMPA 1 antibody; GLUH1 antibody; GLUR1 antibody; GLURA antibody; GluA1 antibody; HBGR1 antibody; MGC133252 antibody; AMPA 1 antibody; gluR-1 antibody; gluR-A antibody; gluR-K1 antibody; glutamate receptor 1 antibody; AMPA1 / GLUR1 (aa264-277)

glutamate receptor 1 isoform 1; Glutamate receptor 1; glutamate receptor 1; glutamate ionotropic receptor AMPA type subunit 1; AMPA-selective glutamate receptor 1; GluR-A; GluR-K1; Glutamate receptor ionotropic, AMPA 1; GluA1

GRIA1

AMPA1;GLUR1

GRIA1; GRIA1; GLUH1; GLUR1; GLURA; GluA1; HBGR1; GLUH1; GLUR1; GluR-1; GluA1

GRIA1_HUMAN

多克隆

山羊

Tested: Human, Mouse, Rat; Expected from sequence similarity: Human, Mouse, Rat, Dog, Cow

906

KIMQQWKNSDARD

通过硫酸铵沉淀和用免疫多肽抗原亲和层析从山羊血清中纯化得到的

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

100ug specific antibody in 200ul

Aliquot and store at -20 degree C. Minimize freezing and thawing.

肽酶联免疫吸附测定(EIA), 免疫印迹(免疫印迹)

Peptide ELISA: Antibody detection limit dilution 1: 16000. Western Blot: Approx 100kDa band observed in Human, Mouse and Rat Brain (Cerebellum) lysates (calculated MW of 102kDa according to NP_000818.2). Recommended concentration: 0.1-0.3ug/ml.

Immunogen: Peptide with sequence C-KIMQQWKNSDARD, from the internal region of the protein sequence according to NP_000818.2; NP_001107655.1. Epitope: Internal region

Note: This antibody is expected to recognize both reported isoforms (NP_000818.2; NP_001107655.1).

167001419

NP_000818.2

NM_000827.3

102,864 Da

Activation Of AMPA Receptors Pathway (1268797); Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway (1268798); Amphetamine Addiction Pathway (547607); Amphetamine Addiction Pathway (550546); Amyotrophic Lateral Sclerosis (ALS) Pathway (920975); Amyotrophic Lateral Sclerosis (ALS) Pathway (83099); Amyotrophic Lateral Sclerosis (ALS) Pathway (511); Asparagine N-linked Glycosylation Pathway (1268714); BDNF Signaling Pathway (712093); COPII (Coat Protein 2) Mediated Vesicle Transport Pathway (1268727)

Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. This gene belongs to a family of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GluR1: an integral membrane protein belonging to the glutamate-gated ion channel family. L-glutamate (Glu) acts as an excitatory neurotransmitter at many synapses in the central nervous system. Glutamate receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. Each of the four GluR proteins (GRIA1-4) include flip and flop isoforms generated by alternative RNA splicing. Expressed in granule and pyramidal cells in the hippocampal formation. Protein type: Membrane protein, integral; Membrane protein, multi-pass; Channel, ligand-gated; Channel, calcium. Chromosomal Location of Human Ortholog: 5q31.1. Cellular Component: cell junction; cell soma; cell surface; dendrite; dendritic spine; endoplasmic reticulum membrane; ER-Golgi intermediate compartment membrane; Golgi membrane; plasma membrane; postsynaptic density; postsynaptic membrane; recycling endosome; synaptic vesicle. Molecular Function: alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity; excitatory extracellular ligand-gated ion channel activity; extracellular-glutamate-gated ion channel activity; glutamate receptor activity; PDZ domain binding; protein binding. Biological Process: COPII coating of Golgi vesicle; ER to Golgi vesicle-mediated transport; ionotropic glutamate receptor signaling pathway; long-term memory; receptor internalization; signal transduction; synaptic transmission

0.1毫克

300美元