产品简要
公司名称 :
MyBioSource
产品类型 :
抗体
产品名称 :
山羊抗MNSOD(aa119-130)抗体
目录 :
MBS422763
规格 :
0.1毫克
价格 :
300美元
克隆性 :
多克隆
宿主 :
山羊
共轭标签 :
未共轭
反应物种 :
人类, 小鼠, 大鼠, 狗, 斑马鱼
应用 :
免疫印迹, 酶免疫法
更多信息或购买 :
产品信息
目录号 :
MBS422763
产品类型 :
抗体
产品全称 :
山羊抗MNSOD(aa119-130)抗体
产品简称 :
MNSOD
产品名称同义词 :
Goat Anti-MNSOD (isoform A) Antibody; SOD2; superoxide dismutase 2, mitochondrial; RP1-56L9.2; IPOB; MNSOD; MVCD6; Mn superoxide dismutase; indophenoloxidase B; manganese-containing superoxide dismutase; mangano-superoxide dismutase; superoxide dismutase [Mn], mitochondrial; SOD2 antibody; superoxide dismutase 2; mitochondrial antibody; RP1-56L9.2 antibody; IPOB antibody; MNSOD antibody; MVCD6 antibody; Mn superoxide dismutase antibody; indophenoloxidase B antibody; manganese-containing superoxide dismutase antibody; superoxide dismutase [Mn]; mitochondrial antibody; MNSOD (aa119-130)
其他名称 :
superoxide dismutase; Superoxide dismutase [Mn], mitochondrial; superoxide dismutase [Mn], mitochondrial; superoxide dismutase 2, mitochondrial
产品基因名称 :
SOD2
产品基因名称同义词 :
MNSOD
其他基因名称 :
SOD2; SOD2; IPOB; IPO-B; MNSOD; MVCD6; Mn-SOD
UniProt数据库进入名 :
SODM_HUMAN
克隆性 :
多克隆
宿主 :
山羊
反应物种 :
Tested: Human, Mouse, Rat; Expected from sequence similarity: Human, Mouse, Rat, Dog, Pig, Cow, Zebrafish
序列长度 :
222
序列 :
EAIKRDFGSFDK
纯度 :
通过硫酸铵沉淀和用免疫多肽抗原亲和层析从山羊血清中纯化得到的
形式 :
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
浓度 :
100ug specific antibody in 200ul
储存稳定性 :
Aliquot and store at -20 degree C. Minimize freezing and thawing.
检测过的应用 :
肽酶联免疫吸附测定(EIA), 免疫印迹(免疫印迹)
应用笔记 :
Peptide ELISA: Antibody detection limit dilution 1: 64000. Western Blot: Approx 24kDa band observed in Human Brain (cerebellum) lysates and in Mouse and Rat Brain and Spinal Cord lysates, while approx 26kDa band was observed in lysates of cell lines HeLa, HepG2, HEK293 and NIH3T3 (calculated MW of 24.8kDa according to Human NP_000627.2, and 24.6kDa according to Mouse NP_038699.2). Recommended concentration: 0. 01-0.1ug/ml.
其它信息1 :
Immunogen: Peptide with sequence C-EAIKRDFGSFDK, from the internal region of the protein sequence according to NP_000627.2; NP_001019637.1. Epitope: Internal region
其他信息2 :
Note: NB: The immunizing peptide represents the acetylation site including K122 according to isoform A. This antibody is expected to recognize both reported isoforms (NP_000627.2; NP_001019637.1). Reported variants represent identical protein: NP_000627.2; NP_001019636.1.
NCBI GI登录号 :
67782305
NCBI登录号 :
NP_000627.2
NCBI基因登录号 :
NM_000636.3
NCBI分子量 :
19,730 Da
NCBI信号通路 :
Cellular Responses To Stress Pathway (1270414); DNA Damage Response (only ATM Dependent) Pathway (198827); Detoxification Of Reactive Oxygen Species Pathway (1270420); FoxO Family Signaling Pathway (138036); FoxO Signaling Pathway (921162); Huntington's Disease Pathway (83100); Huntington's Disease Pathway (512); Longevity Regulating Pathway (1319989); Longevity Regulating Pathway - Multiple Species (1340713); Longevity Regulating Pathway - Multiple Species (1340651)
NCBI总结 :
This gene is a member of the iron/manganese superoxide dismutase family. It encodes a mitochondrial protein that forms a homotetramer and binds one manganese ion per subunit. This protein binds to the superoxide byproducts of oxidative phosphorylation and converts them to hydrogen peroxide and diatomic oxygen. Mutations in this gene have been associated with idiopathic cardiomyopathy (IDC), premature aging, sporadic motor neuron disease, and cancer. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been identified on chromosome 1. [provided by RefSeq, Apr 2016]
UniProt数据库总结 :
SOD2: Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. Genetic variation in SOD2 is associated with susceptibility to microvascular complications of diabetes type 6 (MVCD6). These are pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new- onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis. Belongs to the iron/manganese superoxide dismutase family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Oxidoreductase; EC 1.15.1.1; Mitochondrial. Chromosomal Location of Human Ortholog: 6q25.3. Cellular Component: mitochondrial matrix; mitochondrion. Molecular Function: identical protein binding; manganese ion binding; superoxide dismutase activity. Biological Process: acetylcholine vasodilation involved in regulation of systemic arterial blood pressure; age-dependent response to reactive oxygen species; negative regulation of cell proliferation; negative regulation of neuron apoptosis; oxygen homeostasis; protein homotetramerization; regulation of blood pressure; regulation of transcription from RNA polymerase II promoter; release of cytochrome c from mitochondria; removal of superoxide radicals; response to reactive oxygen species; response to superoxide; superoxide metabolic process. Disease: Microvascular Complications Of Diabetes, Susceptibility To, 6
尺寸1 :
0.1毫克
价格1 :
300美元
更多信息或购买 :
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华,公司愿景是“生物研究试剂的源头”,现在位于圣地亚哥市。