抗体

IgA分泌成分/ECM1小鼠单克隆抗体

MBS438012

0.02 mg (With BSA &

150美元

单克隆

小鼠

未共轭

SPM217

人类, 大鼠

免疫组化, 免疫细胞化学, 流式细胞仪, 流式细胞仪

抗体

IgA分泌成分/ECM1小鼠单克隆抗体

IgA分泌成分/ECM1

ECM1, 细胞外基质蛋白1, 分泌成分p85, URBWD

extracellular matrix protein 1 isoform 3; Extracellular matrix protein 1; extracellular matrix protein 1; extracellular matrix protein 1; Secretory component p85

ECM1

ECM1;ECM1;URBWD

ECM1_HUMAN

单克隆

IgG1, kappa

SPM217

小鼠

人类, 大鼠

567

This MAb reacts with a reduction-resistant epitope present in both free and SIgA bound Secretory Component. It does not react with the cell lines lacking secretory component. The antibody is useful for studying the distribution and level of both free and bound secretory component. Secretory component is differentially expressed in epithelium, and the antibody is a popular marker for identifying subpopulations of epithelial cells and epithelial differentiation. The Secretory component antibody is a useful research tool for studying mucosal immunity, inflammation, remodeling, differentiation and tumorigenesis, all processes associated with differential secretory component expression.

200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Antibody with azide - store at 2 to 8 degree C. Antibody without azide - store at -20 to -80 degree C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

流式细胞仪(FC/流式细胞仪), 免疫荧光(IF), 免疫组化(免疫组化)福尔马林

Flow Cytometry (0.5-1ug/million cells in 0.1ml). Immunofluorescence (1-2ug/ml). Immunohistochemistry (Formalin-fixed) (0.5-1ug/ml for 30 minutes at RT) (Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)

Cellular Localization: Cell Surface and Cytoplasmic. Immunogen: Secretory Component protein isolated from human colostrum

Hu-Chromosome Location: 1q21.2. Positive Control: Stomach, Lung, or breast tumor

Bartek J et. al. Histochemistry 91:235-244 (1989)

322302700

NP_001189787.1

NM_001202858.1

Q16610

~80kDa

Hemostasis Pathway (1269340); Platelet Activation, Signaling And Aggregation Pathway (1269350); Platelet Degranulation Pathway (1269367); Response To Elevated Platelet Cytosolic Ca2+ Pathway (1269365)

This gene encodes a soluble protein that is involved in endochondral bone formation, angiogenesis, and tumor biology. It also interacts with a variety of extracellular and structural proteins, contributing to the maintenance of skin integrity and homeostasis. Mutations in this gene are associated with lipoid proteinosis disorder (also known as hyalinosis cutis et mucosae or Urbach-Wiethe disease) that is characterized by generalized thickening of skin, mucosae and certain viscera. Alternatively spliced transcript variants encoding distinct isoforms have been described for this gene. [provided by RefSeq, Feb 2011]

ECM1: Involved in endochondral bone formation as negative regulator of bone mineralization. Stimulates the proliferation of endothelial cells and promotes angiogenesis. Inhibits MMP9 proteolytic activity. Defects in ECM1 are the cause of lipoid proteinosis (LiP); also known as lipoid proteinosis of Urbach and Wiethe or hyalinosis cutis et mucosae. LiP is a rare autosomal recessive disorder characterized by generalized thickening of skin, mucosae and certain viscera. Classical features include beaded eyelid papules and laryngeal infiltration leading to hoarseness. Histologically, there is widespread deposition of hyaline material and disruption/reduplication of basement membrane. 4 isoforms of the human protein are produced by alternative splicing. Protein type: Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 1q21. Cellular Component: extracellular matrix; extracellular region. Molecular Function: enzyme binding; laminin binding; protease binding; protein binding; protein C-terminus binding; signal transducer activity. Biological Process: negative regulation of bone mineralization; negative regulation of peptidase activity; platelet degranulation; positive regulation of angiogenesis; positive regulation of endothelial cell proliferation; positive regulation of I-kappaB kinase/NF-kappaB cascade. Disease: Lipoid Proteinosis Of Urbach And Wiethe

0.02 mg (With BSA & Azide at 0.2 mg/ml)

150美元

7 ml (Prediluted)

270

0.1 mg (With BSA & Azide at 0.2mg/ml)

270

0.1 mg (Without BSA & Azide at 1mg/ml)

285

0.2 mg (With BSA & Azide at 0.2mg/ml)

360