抗体

Interleukin 10 (IL10) (Immunoregulation Marker)

MBS4380606

0.02 mg (With BSA & Azide at 0.2 mg/ml)

190美元

单克隆

兔

未共轭

[白细胞介素10/2651R]

抗体

Interleukin 10 (IL10) (Immunoregulation Marker)

[白细胞介素10(白细胞介素10)]

[Cytokine Synthesis Inhibitory Factor (CSIF); GVHDS; IL-10; IL10; IL10A; Interleukin-10; T-cell Growth Inhibitory Factor (TGIF)]

[白细胞介素10;白细胞介素10;白细胞介素10;白细胞介素10;细胞因子合成抑制因子;CSIF]

[白细胞介素10]

[白细胞介素10;白细胞介素10;CSIF;TGIF;GVHDS;IL-10;IL10A;IL-10;CSIF]

单克隆

IgG

[白细胞介素10/2651R]

兔

Human. Others not known.

178

Interleukin 10 (IL10) is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immuno-regulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II antigens, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immuno-regulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.

200ug/ml of Ab purified by Protein A. Prepared in 1mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Antibody with azide store at 2-8°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Immunohistology (Formalin-Fixed)

Immunohistology (Formalin-Fixed): 1-2ug/ml for 30 minutes at RT ( Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes.). Optimal dilution for a specific application should be determined.

免疫组化(免疫组化)

免疫组化(免疫组化)

SDS-Page

Immunogen: Recombinant full-length human Interleukin 10 (IL10) protein. Positive Control: SK-BR3 Cells. Adrenal, Lymph Node, Bladder, Prostate or Endometrium.

Cellular Localization: Cytoplasmic (secreted) and Cell Surface. Chromosome Location: 1q32.1

重组兔单克隆抗体

Fleming, S.D. and Campbell, P.A. 1996. Macrophages have cell surface IL-10 that regulates macrophage bactericidal activity. J. Immunol. 156: 1143-1150.; Bromberg, J.S. 1995. IL-10 immunosuppression in transplantation. Curr. Opin. Immunol. 7: 639-643.

10835141

NP_000563.1

NM_000572.3

P22301

20kDa (Monomer); 37kDa (Dimer)

The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.[provided by RefSeq, May 2011]

Inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells.

0.02 mg (With BSA & Azide at 0.2 mg/ml)

190美元

0.1 mg (With BSA & Azide at 0.2mg/ml)

340

0.1 mg (Without BSA & Azide at 1mg/ml)

340