抗体

PAX7(横纹肌肉瘤标记)小鼠单克隆抗体

MBS438177

0.02 mg (With BSA & Azide at 0.2 mg/ml)

190美元

单克隆

小鼠

未共轭

[PAX7/497]

人类, 小鼠, 斑马鱼

免疫印迹, 免疫细胞化学, 流式细胞仪, 流式细胞仪

抗体

PAX7(横纹肌肉瘤标记)小鼠单克隆抗体

[PAX7]

[HUP1; Paired box gene 7; Paired box homeotic gene 7; Paired domain gene HuP1; PAX7 transcriptional factor; PAX7/FKHR fusion gene; PAX7B; RMS2]

[paired box protein Pax-7 isoform 3; Paired box protein Pax-7; paired box protein Pax-7; paired box 7; HuP1]

[PAX7]

[PAX7;PAX7;HUP1;RMS2;PAX7B;HUP1]

PAX7_HUMAN

单克隆

IgG1, kappa

[PAX7/497]

小鼠

人类, 小鼠, 大鼠鸡, 斑马鱼

505

The Pax gene family of nuclear transcription factors is comprised of nine members that function during embryogenesis to regulate the temporal and position-dependent differentiation of cells. In addition, the family is involved in a variety of signal transduction pathways in the adult organism. Mutations in the Pax family of proteins have been linked to disease and cancer in humans. Pax-7 is a protein specifically expressed in cultured satellite cell-derived myoblasts. In situ hybridization reveals that Pax-7 is also expressed in satellite cells residing in adult muscle. A chromosomal aberration in the gene encoding Pax-7 causes rhabdomyosarcoma 2 (RMS2) (also called alveolar rhabdomyosarcoma).

200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Antibody with azide - store at 2 to 8 degree C. Antibody without azide - store at -20 to -80 degree C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

免疫荧光(IF), 流式细胞仪(FC/流式细胞仪), 免疫印迹(免疫印迹)

Immunofluorescence (0.5-1ug/ml). Flow Cytometry (0.5-1ug/million cells in 0.1ml). Western Blot (0.5-1ug/ml). Optimal dilution for a specific application should be determined.

免疫印迹(免疫印迹)

十二烷基磺酸钠-PAGE

Cellular Localization: Nuclear. Immunogen: Recombinant fragment (aa300-600) of human PAX7 protein

Hu-Chromosome Location: 1p36.13. Positive Control: HeLa, Jurkat, A431, MCF-7, U2OS or NIH/3T3 cells. Rhabdomyosarcoma (RMS)

207029223

NP_001128726.1

NM_001135254.1

P23759

57kDa

Neural Crest Differentiation Pathway (672460); Transcriptional Misregulation In Cancer Pathway (523016); Transcriptional Misregulation In Cancer Pathway (522987); MiRs In Muscle Cell Differentiation Pathway (672449)

This gene is a member of the paired box (PAX) family of transcription factors. Members of this gene family typically contain a paired box domain, an octapeptide, and a paired-type homeodomain. These genes play critical roles during fetal development and cancer growth. The specific function of the paired box 7 gene is unknown but speculated to involve tumor suppression since fusion of this gene with a forkhead domain family member has been associated with alveolar rhabdomyosarcoma. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]

PAX7: Probable transcription factor. May have a role in myogenesis. Defects in PAX7 are a cause of rhabdomyosarcoma type 2 (RMS2). It is a form of rhabdomyosarcoma, a highly malignant tumor of striated muscle derived from primitive mesenchimal cells and exhibiting differentiation along rhabdomyoblastic lines. Rhabdomyosarcoma is one of the most frequently occurring soft tissue sarcomas and the most common in children. It occurs in four forms: alveolar, pleomorphic, embryonal and botryoidal rhabdomyosarcomas. A chromosomal aberration involving PAX7 is found in rhabdomyosarcoma. Translocation t(1;13)(p36;q14) with FOXO1. The resulting protein is a transcriptional activator. Belongs to the paired homeobox family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: DNA-binding; Transcription factor; Oncoprotein. Chromosomal Location of Human Ortholog: 1p36.13. Molecular Function: transcription factor activity. Biological Process: anatomical structure morphogenesis; negative regulation of apoptosis. Disease: Rhabdomyosarcoma 2

0.02 mg (With BSA & Azide at 0.2 mg/ml)

190美元

0.1 mg (With BSA & Azide at 0.2mg/ml)

340

0.1 mg (Without BSA & Azide at 1mg/ml)

340