抗体

CD11c(树状细胞标记)小鼠单克隆抗体

MBS439537

0.02 mg (With BSA & Azide at 0.2 mg/ml)

190美元

单克隆

小鼠

未共轭

免疫组化, 免疫细胞化学, 流式细胞仪, 流式细胞仪

抗体

CD11c(树状细胞标记)小鼠单克隆抗体

[CD11c]

[CD11 antigen-like family member C; Complement component 3 receptor 4 subunit; Integrin alpha-X; integrin, alpha X (antigen CD11C (p150), alpha polypeptide); Leu M5 alpha subunit; Leukocyte adhesion glycoprotein p150 95 alpha chain; Myeloid membrane antigen alpha subunit; p150/95]

[integrin alpha-X isoform 2; Integrin alpha-X; integrin alpha-X; integrin subunit alpha X; CD11 antigen-like family member C; Leu M5; Leukocyte adhesion glycoprotein p150,95 alpha chain; Leukocyte adhesion receptor p150,95; CD_antigen: CD11c]

[ITGAX]

[ITGAX;ITGAX;CD11C;SLEB6;CD11C]

ITAX_HUMAN

单克隆

IgG2b, kappa

小鼠

Human.Others not known.

1163

Recognizes a protein of 145kDa, identified as CD11c. CD11c (ITGAX), a member of the leukointegrin family, shares the same beta subunit with other members of the leukocyte adhesion molecule family, which includes CD11a (LFA-1), CD11b (MAC-1) and CD11d (ITGAD), but has a unique alpha chain. CD11c has been shown to play a role in phagocytosis, cell migration, and cytokine production by monocytes/macrophages as well as induction of T-cell proliferation by Langerhans cells. CD11c is expressed prominently on the plasma membranes of monocytes, tissue macrophages, NK cells, and most dendritic cells (DCs). A lower level of expression is also observed on neutrophils as a result of its high level of expression on most DCs. An antibody to CD11c may aid in identification of lesions with histiocytic origin. It may also been used as a marker for hairy cell leukemia in paraffin-embedded tissues.

200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Antibody with azide - store at 2 to 8°C.

流式细胞仪(FC/流式细胞仪), 免疫荧光(IF), 免疫组化(免疫组化)福尔马林

Flow Cytometry (0.5-1 ug/million cells). Immunofluorescence (0.5-1ug/mL). Immunohistology (Formalin-fixed)(1-2ug/mL for 30 min at RT). Staining of formalin-fixxed tissues requires boiling tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 10-20 min followed by cooling at RT for 20 min. Optimal dilution for specific application should be determined.

Cellular Localization: Cell Surface. Immunogen: Recombinant human ITGAX protein fragment (aa 637-827)

Hu-Chromosome Location: 16p11.2. Positive Control: Human dendritic cells. Human lymph nodes and tonsils.

Nicolaou, F., et al. 2003. CD11c gene expression in hairy cell leukemia is dependent upon activation of the proto-oncogenes Ras and JunD. Blood 101: 4033-4041

34452173

NP_000878.2

NM_000887.4

P20702

145kDa

Cell Surface Interactions At The Vascular Wall Pathway (1269373); Complement And Coagulation Cascades Pathway (83073); Complement And Coagulation Cascades Pathway (484); ECM Proteoglycans Pathway (1270256); Extracellular Matrix Organization Pathway (1270244); Focal Adhesion Pathway (198795); Hemostasis Pathway (1269340); Integrin Cell Surface Interactions Pathway (1270260); Integrin-mediated Cell Adhesion Pathway (198816); Regulation Of Actin Cytoskeleton Pathway (83089)

This gene encodes the integrin alpha X chain protein. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as inactivated-C3b (iC3b) receptor 4 (CR4). The alpha X beta 2 complex seems to overlap the properties of the alpha M beta 2 integrin in the adherence of neutrophils and monocytes to stimulated endothelium cells, and in the phagocytosis of complement coated particles. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]

ITGAX: Integrin alpha-X/beta-2 is a receptor for fibrinogen. It recognizes the sequence G-P-R in fibrinogen. It mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and chemotaxis. Belongs to the integrin alpha chain family. Protein type: Membrane protein, integral; Motility/polarity/chemotaxis. Chromosomal Location of Human Ortholog: 16p11.2. Cellular Component: cell surface; membrane; plasma membrane. Molecular Function: protein binding; receptor activity. Biological Process: cell adhesion; extracellular matrix organization and biogenesis; heterotypic cell-cell adhesion; leukocyte migration; organ morphogenesis. Disease: Systemic Lupus Erythematosus

0.02 mg (With BSA & Azide at 0.2 mg/ml)

190美元

0.1 mg (With BSA & Azide at 0.2mg/ml)

340

0.1 mg (Without BSA & Azide at 1mg/ml)

340