产品简要
公司名称 :
MyBioSource
产品类型 :
抗体
产品名称 :
B细胞淋巴瘤2相关的X蛋白(A20)抗体
目录 :
MBS440005
规格 :
0.2毫克
价格 :
240美元
克隆性 :
多克隆
宿主 :
共轭标签 :
未共轭
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 免疫组化, 免疫沉淀
更多信息或购买 :
产品信息
目录号 :
MBS440005
产品类型 :
抗体
产品全称 :
B细胞淋巴瘤2相关的X蛋白(A20)抗体
产品简称 :
B细胞淋巴瘤2相关的X蛋白
其他名称 :
bax, partial; Apoptosis regulator BAX; apoptosis regulator BAX; Bcl2-associated X protein
产品基因名称 :
B细胞淋巴瘤2相关的X蛋白
其他基因名称 :
B细胞淋巴瘤2相关的X蛋白;B细胞淋巴瘤2相关的X蛋白
UniProt数据库进入名 :
BAX_RAT
克隆性 :
多克隆
宿主 :
反应物种 :
小鼠, 大鼠, 人类
序列长度 :
133
特异性 :
小鼠, 大鼠和人类B细胞淋巴瘤2相关的X蛋白
形式 :
200微克/毫升兔多克隆IgG在1毫升PBS含0.1% 叠氮化钠和0.2% 明胶
浓度 :
0.200毫克/毫升
储存稳定性 :
Store this product at 4 degree C, do not freeze. The product is stable for one year from the date of shipment.
检测过的应用 :
免疫印迹(免疫印迹), 免疫沉淀(免疫沉淀), 免疫组化(免疫组化)
其它信息1 :
Origin: Bax is provided as an affinity purified rabbit polyclonal antibody, raised against a peptide mapping to the amino terminus of human Bax.
其他信息2 :
Immunogen: Synthetic peptide mapping to the amino terminal domain of human Bax
产品描述 :
Bcl-2 family of proteins is a key regulator of apoptosis that function to either inhibit or promote cell death. The over expression of members such as Bcl-2 and Bcl-xL inhibit the apoptotic process (1,2). The Bcl-2 family members are also characterized by dimerizing to further modulate apoptosis. Bag-1, for example, has been found to form a heterodimer with Bcl-2 resulting in the enhancement of the anti-apoptotic effect of Bcl-2 (3,4). Other anti-apoptotic Bcl-2 family members include A1, Bcl-xg, Bcl-xb, Mcl-1, BAR, BI-1 and Bcl-w (5). The pro-apoptotic family members include Bax, Bcl-xS, Bad, Bak, NBK, BID, Hrk, Bok, Bim, Noxa and Diva. Bax and Bak have been shown to play a critical role in cytochrome c release from mitochondria and thus initiate apoptosis (6). Bad plays a critical role in the Bax-mediated apoptosis pathway by dimerizing with Bcl-xL, causing the displacment of Bax. The displacement of Bax allows apoptosis to proceed (7). Bcl-xS, a shorter version of Bcl-xL (lacking amino acids 126-188), apparently utilizes a different pathway than Bax to induce cell death. Some research suggests that Bcl-xS uses a novel mechanism for regulating caspase or it may use an alternate cell death effector pathway (8,9).
产品引用 :
1.) You WK, Seo HJ, Chung KH, Kim DS. 2003. A novel metalloprotease from Gloydius halys venom induces endothelial cell apoptosis through its protease and disintegrin-like domains. J Biochem (Tokyo) Nov;134(5):739-49. 2.) Kim J, Seong J, and Kim SH. 2004. Enhancement of Tumor Response by Farnesyltransferase Inhibitor in C3H/HeJ Hepatocarcinoma. Ann N Y Acad Sci. Dec;1030:95-102. 3.) Ma D, Hossain M, Chow A, Arshad M, Battson RM, Sanders RD, Mehmet H, Edwards AD, Franks NP, Maze M. 2005. Xenon and hypothermia combine to provide neuroprotection from neonatal asphyxia. Ann Neurol. Aug;58(2):182-93.4.) Wan Y, Xu J, Ma D, Zeng Y, Cibelli M, Maze M. 2007. Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus. Anesthesiology. Mar;106(3):436-43. 1. Huang Z. 2000. Bcl-2 family proteins as targets for anticancer drug design. Oncogene 19(56): 6627-66312. Reed JC. 1997. Double identity for proteins of the Bcl-2 family. Nature 387(6635): 773-7763. Eversole-Cire P, Concepcion FA, Simon MI, Takayama S, Reed JC, Chen J. 2000. Synergistic effect of Bcl-2 and BAG-1 on the prevention of photoreceptor cell death. Invest Ophthalmol Vis Sci 41(7): 1953-19614. Coldwell MJ, deSchoolmeester ML, Fraser GA, Pickering BM, Packham G, Willis AE. 2001. The p36 isoform of BAG-1 is translated by internal ribosome entry following heat shock. Oncogene 20(30): 4095-41005. Bae j, Hsu SY, Leo CP, Zell K, Hsueh AJ. 2001. Underphosphorylated BAD interacts with diverse antiapoptotic Bcl-2 family proteins to regulate apoptosis. Apoptosis 6(5): 319-3306. Wei MC, Zong WX, Cheng EH, Lindsten T, Panoutsakopoulou V, Ross AJ, Roth KA, MacGregor GR, Thompson CB, Korsmeyer SJ. 2001. Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death. Science 292(5517): 624-6267. Yang E, Zha J, Jockel J, Boise LH, Thompson CB, Korsmeyer SJ. 1995. Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death. Cell 80(2): 285-2918. Fridman JS, Parsels J, Rehemtulla A, Maybaum J. 2001. Cytochrome c depletion upon expression of Bcl-XS. J Biol Chem 276(6): 4205-109. Lindenboim L, Yuan J, Stein R. 2000. Bcl-xS and Bax induce different apoptotic pathways in PC12 cells. Oncogene 19(14): 1783-1793
NCBI GI登录号 :
975870
NCBI登录号 :
AAA75200.1
UniProt数据库登录号 :
Q63690
NCBI分子量 :
Da
NCBI信号通路 :
ATM Pathway 198524!!Activation, Translocation And Oligomerization Of BAX Pathway 1178315!!Amyotrophic Lateral Sclerosis (ALS) Pathway 83491!!Amyotrophic Lateral Sclerosis (ALS) Pathway 511!!Apoptosis Pathway 219785!!Apoptosis Pathway 83452!!Apoptosis Pathway 470!!Apoptosis Pathway 1178301!!B Cell Receptor Signaling Pathway 198486!!Colorectal Cancer Pathway 83494
NCBI总结 :
Bcl2-related gene; involved in the regulation of apoptotic cell death [RGD, Feb 2006]
规格 :
0.2毫克
价格 :
240美元
更多信息或购买 :
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华,公司愿景是“生物研究试剂的源头”,现在位于圣地亚哥市。