产品简要
公司名称 :
MyBioSource
产品类型 :
抗体
产品名称 :
ZO-1多克隆抗体
目录 :
MBS448025
规格 :
0.6毫克
价格 :
410美元
克隆性 :
多克隆
宿主 :
山羊
共轭标签 :
未共轭
反应物种 :
小鼠, 大鼠,
应用 :
免疫印迹, 免疫细胞化学
更多信息或购买 :
产品信息
目录号 :
MBS448025
产品类型 :
抗体
产品全称 :
ZO-1多克隆抗体
产品简称 :
ZO-1
产品名称同义词 :
Anti-ZO-1; ZO-1 and zona occludens protein 1 antibody
其他名称 :
ZO-1; Tight junction protein ZO-1; tight junction protein ZO-1; zona occludens protein 1; zonula occludens protein 1; tight junction protein 1; Tight junction protein 1; Zona occludens protein 1; Zonula occludens protein 1
产品基因名称 :
ZO-1
其他基因名称 :
紧密连接蛋白-1;紧密连接蛋白-1;ZO1;Zo1
UniProt数据库进入名 :
ZO1_MOUSE
克隆性 :
多克隆
抗体亚型 :
IgG
宿主 :
山羊
反应物种 :
Reacts against human, rat, mouse, canine and monkey proteins.
序列长度 :
1745
特异性 :
Detects endogenous levels of total ZO-1 by Western blot in whole cell and tissue lysates.
形式 :
Polyclonal antibody supplied as a 200 ul(3 mg/ml) aliquot in PBS, 20% glycerol and 0.05%
储存稳定性 :
Store at -20 degree C for long-term storage. Store at 2-8 degree C for up to one month. A void freeze/thaw cycles.
检测过的应用 :
免疫荧光(IF), 免疫印迹(免疫印迹)
应用笔记 :
Western blot: 1:500-1:2,000. lmm unofl uorescence: 1:50-1:250. Immunohistochemistry (paraffin): 1:50-1:200. Immunohistochemistry (frozen): 1:50-1:200
其它信息1 :
Gene Identifier: ENSG00000104067. Immunogen: Purified recombinant peptide derived from within residues 1580 aa to the C-terminus of human ZO-1 produced in E. coli.
其他信息2 :
Handling: The antibody solution should be gently mixed before use.
产品描述 :
Goat polyclonal to TJPl tight Junction protein 1 (TJP1). TJPl is located on a cytoplasmic membrane surface of intercellular tight junctions and may be involved m signal transduction at cell-cell junctions.
NCBI GI登录号 :
303710
NCBI登录号 :
BAA03274.1
UniProt数据库登录号 :
P39447
NCBI分子量 :
194,742 Da
NCBI信号通路 :
Adherens Junction Pathway (83267); Adherens Junction Pathway (481); Gap Junction Pathway (83269); Gap Junction Pathway (483); Gap Junction Trafficking And Regulation Pathway (927299); Membrane Trafficking Pathway (927292); PodNet: Protein-protein Interactions In The Podocyte Pathway (755428); Regulation Of Gap Junction Activity Pathway (927308); Salmonella Infection Pathway (375174); Salmonella Infection Pathway (375149)
UniProt数据库总结 :
Function: The N-terminal may be involved in transducing a signal required for tight junction assembly, while the C-terminal may have specific properties of tight junctions. The alpha domain might be involved in stabilizing junctions. Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells . By similarity. Subunit structure: Homodimer, and heterodimer with TJP2/ZO-2 and TJP3/ZO-3. Interacts with CGN/cingulin, CALM, CXADR, GJD3, HSPA4 and UBN1. Interacts (via ZU5 domain) with CDC42BPB. Interacts (via PDZ domain) with GJA1 . By similarity. Interacts with OCLN, claudins, GJA12 and KIRREL1. Interacts with BVES (via the C-terminus cytoplasmic tail). Interacts (via ZU5 domain) with MYZAP. Interacts (via PDZ domains) with ANKRD2 . By similarity. Ref.3 Ref.4 Ref.5 Ref.12. Subcellular location: Cell membrane; Peripheral membrane protein; Cytoplasmic side . By similarity. Cell junction tight junction . By similarity. Cell junction gap junction. Cytoplasm myofibril sarcomere I band. Note: Moves from the cytoplasm to the cell membrane concurrently with cell-cell contact. Detected at the leading edge of migrating and wounded cells . By similarity. Ref.12. Domain: The second PDZ domain mediates interaction with GJA12. Ref.4. Post-translational modification: Phosphorylated. Dephosphorylated by PTPRJ . By similarity. Sequence similarities: Belongs to the MAGUK family.Contains 1 guanylate kinase-like domain.Contains 3 PDZ (DHR) domains.Contains 1 SH3 domain.Contains 1 ZU5 domain.
尺寸1 :
0.6毫克
价格1 :
410美元
更多信息或购买 :
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华,公司愿景是“生物研究试剂的源头”,现在位于圣地亚哥市。