抗体

抗VEGFR2

MBS448083

0.6毫克

300美元

多克隆

山羊

未共轭

人类, 狗

抗体

抗VEGFR2

[VEGFR2]

[CD309; Fetal liver kinase 1; FLK1; Kinase insert domain receptor; Protein-tyrosine kinase receptor flk-1; VEGFR; VEGF receptor 2; Vascular endothelial growth factor receptor 2 antibody]

[vascular endothelial growth factor receptor 2; Vascular endothelial growth factor receptor 2; vascular endothelial growth factor receptor 2; fetal liver kinase 1; fetal liver kinase-1; kinase insert domain receptor (a type III receptor tyrosine kinase); protein-tyrosine kinase receptor Flk-1; soluble VEGFR2; tyrosine kinase growth factor receptor; kinase insert domain receptor; Fetal liver kinase 1; FLK-1; Kinase insert domain receptor; KDR; Protein-tyrosine kinase receptor flk-1; CD_antigen: CD309]

[激酶插入区受体;激酶插入区受体;FLK1;CD309;VEGFR;VEGFR2;FLK1;VEGFR2;VEGFR-2;FLK-1;激酶插入区受体]

VGFR2_HUMAN

多克隆

IgG

山羊

人类, 狗和小鼠蛋白

1356

This antibody reacts with a 180 kDa protein and detects endogenous levels of total VEGFR2 protein.

表位亲和纯化

Polyclonal antibody supplied as a 200 ul (3 mg/ml) aliquot in PBS, 20% glycerol and 0.05% sodium azide. This antibody is epitope-affinity purified from goat antiserum.

Store at -20°C for long-term storage. Store at 2-8°C for up to one month. Avoid freeze/thaw cycles.

免疫印迹(免疫印迹)

Western Blot: 1:250-1:2,000. Immunofluorescence: 1:25-1:250

试验数据

Immunogen: Recombinant peptide derived from the N-terminus (residues 20-125 aa) of human VEGFR2 produced in E.coli). Handling: The antibody solution should be gently mixed before use. Conjugation: Unconjugated

Antigen: Purified recombinant peptide derived from the N-terminus (residues 20-125 aa) of human VEGFR2 produced in E. coli.

Goat polyclonal to VEGFR2. VEGFR2 known as kinase insert domain receptor, is a type III receptor tyrosine kinase. This VEGF receptor has a key function in vascular development and regulation of vascular permeability.

11321597

NP_002244.1

NM_002253.2

Vascular endothelial growth factor (VEGF) is a major growth factor for endothelial cells. This gene encodes one of the two receptors of the VEGF. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. It functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc. Mutations of this gene are implicated in infantile capillary hemangiomas. [provided by RefSeq, May 2009]

VEGFR2: a receptor tyrosine kinase of the VEGFR family. High affinity receptor for VEGF and VEGF-C. Ligand binding induces autophosphorylation and activation. Activated receptor recruits proteins including Shc, GRB2, PI3K, Nck, SHP-1 and SHP-2. Plays a key role in vascular development and regulation of vascular permeability. Protein type: EC 2.7.10.1; Protein kinase, tyrosine (receptor); Membrane protein, integral; Kinase, protein; Protein kinase, TK; TK group; VEGFR family. Chromosomal Location of Human Ortholog: 4q11-q12. Cellular Component: Golgi apparatus; endoplasmic reticulum; integral to plasma membrane; cytoplasmic membrane-bound vesicle; early endosome; extracellular region; plasma membrane; nucleus; cell junction; endosome; lipid raft; external side of plasma membrane. Molecular Function: integrin binding; vascular endothelial growth factor receptor activity; protein binding; growth factor binding; protein-tyrosine kinase activity; receptor signaling protein tyrosine kinase activity; transmembrane receptor protein tyrosine kinase activity; Hsp90 protein binding; ATP binding. Biological Process: extracellular matrix organization and biogenesis; positive regulation of positive chemotaxis; peptidyl-tyrosine phosphorylation; viral reproduction; protein amino acid autophosphorylation; cell maturation; calcium ion homeostasis; regulation of cell shape; positive regulation of MAPKKK cascade; ovarian follicle development; positive regulation of focal adhesion formation; positive regulation of mesenchymal cell proliferation; positive regulation of cell proliferation; angiogenesis; vasculogenesis; endothelial cell differentiation; cell fate commitment; embryonic hemopoiesis; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of angiogenesis; cell migration during sprouting angiogenesis; branching morphogenesis of a tube; positive regulation of endothelial cell proliferation; positive regulation of protein amino acid phosphorylation; lymph vessel development; vascular endothelial growth factor receptor signaling pathway; surfactant homeostasis; alveolus development; transmembrane receptor protein tyrosine kinase signaling pathway; positive regulation of cell migration; positive regulation of nitric-oxide synthase biosynthetic process; negative regulation of apoptosis. Disease: Hemangioma, Capillary Infantile

0.6毫克

300美元